Clinical trials: Death, Cardiac
Cardiovascular Disease, Sudden Cardiac Death
Vitamin D and Cardiac Autonomic Tone in Hemodialysis
Despite advances in treatment of conventional cardiovascular risk factors, patients with kidney disease remain at high risk for fatal cardiac events.
- Trial name
- VITAH (NCT01774812)
- Testing
- Alfacalcidol, Ergocalciferol
- Where
- 3 sites in Canada
- Volunteers
- 56 people
- Sponsor
- University of Calgary
Long QT Syndrome, Sleep Apnea
Long QT Syndrome and Sleep Apnea
Obstructive sleep apnea (OSA) has been associated with cardiac repolarization abnormalities and implicated in sudden cardiac death.
- Trial name
- NCT03678311
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Sudden Cardiac Death, Arrhythmia
Comparison of a MAGNET Protocol Versus "off-on" Protocol for Patients With Implantable Cardioverter Defibrillators
The purpose of this study is to compare the two options for management of ICDs (internal cardioverter defibrillators) in patients undergoing procedures with electrocautery: (1) programming ICD therapies "off," or (2) use of a…
- Conditions
- Sudden Cardiac Death, Arrhythmia, Heart Failure
- Trial name
- MAGNET (NCT01599065)
- Testing
- Magnet or Off-On
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Midwest Heart Foundation
Cardiac Event, Sudden Cardiac Death
To Determine Optimal Time for Delivering Electrical Shocks to Cardiac Arrest Patients
In this study, we are comparing the difference in outcomes between patients who were given shocks to the heart, during the upstroke of cardiopulmonary resuscitation (CPR) and before CPR is started.
- Conditions
- Cardiac Event, Sudden Cardiac Death, Death, Ventricular Fibrillation
- Trial name
- NCT01665755
- Testing
- Upstroke Compression Defibrillation, Precompression Defibrillation
- Where
- Singapore
- Volunteers
- 180 people
- Sponsor
- Singapore General Hospital
Left Ventricular Function Systolic Dysfunction
Global Strain and Mechanical Dispersion May Predict Death and Ventricular Arrhythmias Better Than Ejection Fraction
The aim of the study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than ejection fraction(EF) in patients with myocardial infarction and heart failure regardless…
- Trial name
- NCT02286908
- Where
- 8 sites in Czechia, Norway
- Volunteers
- 3,100 people
- Sponsor
- Oslo University Hospital
Cardiovascular Diseases, Myocardial Infarction
Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest
To compare home use of an automatic external defibrillator (AED) to the use of local emergency medical system in treating survivors of sudden cardiac arrest.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Heart Diseases, Death, Sudden, Cardiac
- Trial name
- HAT (NCT00047411)
- Testing
- Cardiopulmonary Resuscitation, Automatic External Defibrillation
- Where
- United States
- Volunteers
- 7,001 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, ICD
SGLT2i As Anti Arrhythmic Therapy to Prevent Sudden Cardiac Deaths.
Failing heart negative remodeling alterations might provide electrical heterogeneity and cardiac remodeling, thus potentially contributing to the occurrence of ventricular arrhythmia and subsequent sudden cardiac death (SCD).
- Conditions
- Heart Failure, ICD, Diabetes Mellitus Type 2, SGLT2i
- Trial name
- NCT03366181
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Campania Luigi Vanvitelli
Cardiovascular Diseases, Arrhythmia
Identifying High Risk Patients With Syncope
To validate two models which categorized patients with syncope into high and low risk for either sudden death or diagnostic arrhythmias based on data available from the initial history, physical examination, and electrocardiogram.
- Conditions
- Cardiovascular Diseases, Arrhythmia, Death, Sudden, Cardiac, Heart Diseases
- Trial name
- NCT00005202
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Extended
Coronary artery disease, or narrowing of the blood vessels that provide blood to the heart, is the most common cause of death in the United States and can be treated with either coronary bypass surgery or coronary stent…
- Trial name
- NCT07308860
- Testing
- FFR-guided PCI, CABG
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Stanford University
Cardiovascular Diseases
Continuation of the nuMoM2b Heart Health Study
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women.
- Trial name
- nuMoM2b-HHS2 (NCT05472597)
- Where
- 14 sites in United States
- Volunteers
- 4,048 people, healthy volunteers welcome
- Sponsor
- RTI International
Mitral Annular Disjunction, Mitral Valve
Loop Recorder Implantation in Patients With Mitral Annular Disjunction
The goal of clinical trial is to prospectively collect data to investigate the prevalence of arrhythmia in young patients diagnosed with mitral annular disjunction who have no indication for implantable cardioverter defibrillator…
- Conditions
- Mitral Annular Disjunction, Mitral Valve, Arrhythmia Ventricular, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- ILR MAD IIT (NCT07436962)
- Testing
- loop recorder implantation
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Arrhythmia, Cardiovascular Diseases
Multicenter Unsustained Tachycardia Trial (MUSTT)
To determine the value of electrophysiologic (EP)-guided antiarrhythmic therapy in coronary heart disease patients at increased risk for sudden death. The study included a controlled clinical trial and a registry.
- Conditions
- Arrhythmia, Cardiovascular Diseases, Coronary Disease, Death, Sudden, Cardiac
- Trial name
- NCT00000480
- Testing
- electrophysiology, anti-arrhythmia agents, defibrillators, implantable
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction, Sudden Death
Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack, have abnormal test results from a 24 hour heart monitor, and who have low normal heart…
- Trial name
- REFINE-ICD (NCT00673842)
- Testing
- Implantable Cardioverter Defibrillator + Usual Care, Usual care
- Where
- 79 sites in United States, Belgium and 13 more
- Volunteers
- 700 people
- Sponsor
- University of Calgary
Sudden Cardiac Arrest
Jewel Electrophysiology (EP) Lab Study
Single arm open label evaluation of the Jewel Patch Wearable Cardioverter Defibrillator (P-WCD) defibrillation waveform in adult cardiac patients.
- Trial name
- NCT05490459
- Testing
- Jewel Patch Wearable Cardioverter Defibrillator (P-WCD)
- Where
- Czechia
- Volunteers
- 18 people
- Sponsor
- Element Science, Inc.
Sudden Cardiac Death, Sudden Cardiac Arrest
Heart Failure Optimization Study
This study is designed as a multi-center prospective observational study of newly diagnosed Heart Failure (HF) patients to test the hypothesis that additional Ejection Fraction (EF) recovery occurs between 90 and 180 days as…
- Conditions
- Sudden Cardiac Death, Sudden Cardiac Arrest, Heart Failure, Heart Failure Low Output
- Trial name
- HF-Opt (NCT03016754)
- Testing
- Wearable Cardioverter Defibrillator
- Where
- 67 sites in United States, Austria and 2 more
- Volunteers
- 602 people
- Sponsor
- Zoll Medical Corporation
Sudden Cardiac Death
Comparison of 50% Tilt and Tuned Waveforms in Single-Coil Active Can Configuration
The purpose of this study is to compare the defibrillation efficacy between the 50/50% tilt biphasic waveform and the Tuned biphasic waveform in a single coil active can configuration.
- Trial name
- PROMISE (NCT00874445)
- Testing
- ICD/ CRT-D
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Chronic Stable Angina, Unstable Angina
The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER Study
The association between alcohol consumption and cardiovascular disease (CVD) has mostly been examined using broad endpoints or cause-specific mortality.
- Conditions
- Chronic Stable Angina, Unstable Angina, Coronary Heart Disease Not Otherwise Specified, Acute Myocardial Infarction
- Trial name
- NCT01864031
- Where
- United Kingdom
- Volunteers
- 2,240,000 people
- Sponsor
- University College, London
Electrocardiogram, Arrhythmias, Cardiac
Model-based Systems for Professional Football Teams, Aimed at Optimizing Health and Performance
LIST OF PLANNED ORIGINAL PUBLICATIONS 1. T wave inversion detection with machine learning to prevent sudden death in professional football players. 2.
- Trial name
- AIPROFB (NCT05872945)
- Testing
- Electrocardiogram
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- RCD Mallorca SAD
Diabetes (DM), Cardio Vascular Disease
Nut Consumption and Prevention of Non-communicable Diseases: A Global Individual Participant Data Meta-analysis
The relationship between nut consumption and the risk of developing non-communicable diseases (NCDs) has been a subject of growing interest.
- Conditions
- Diabetes (DM), Cardio Vascular Disease, Cancer, Dementia
- Trial name
- NUTPOOL (NCT07205978)
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Kidney Transplant
Clinical Outcome of Delayed or Standard Prograf Together With Induction Therapy Followed by Conversion to Advagraf in Donation After Cardiac (or Circulatory) Death (DCD) Kidney Transplant Recipients
The purpose of this study is to confirm non-inferiority of delayed Prograf treatment to standard Prograf treatment in the incidence of delayed graft function (DGF) within 1 week between the 2 immunosuppressive (IS) treatment…
- Trial name
- NCT03644485
- Testing
- Tacrolimus immediate-release formulation, Tacrolimus prolonged-release formulation, Induction therapy
- Where
- 14 sites in China
- Volunteers
- 284 people
- Sponsor
- Astellas Pharma China, Inc.