Clinical trials: Deaths
Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Cardiomyopathies
- Trial name
- HiRO-HCM (NCT05100420)
- Where
- 17 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Montreal Heart Institute
Kidney Disease, Chronic, Renal Transplant Failure
The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD
Rationale: Sodium glucose co transporter 2 (SGLT2) inhibitors are a relatively new class of agents, originally developed as oral antihyperglycemic drugs.
- Conditions
- Kidney Disease, Chronic, Renal Transplant Failure, Heart Failure, Kidney Failure
- Trial name
- NCT05374291
- Testing
- Dapagliflozin 10 mg/day (oral)
- Where
- 101 sites in Australia, Belgium and 4 more
- Volunteers
- 1,750 people
- Sponsor
- University Medical Center Groningen
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Advanced Cancer, End of Life
Resilience-Building for Advance Care Planning
The aims of this study are to (1) assess the feasibility, acceptability, and usability of the ROCKS intervention among patients with advanced cancer and their family caregivers through a randomized controlled trial in a cancer…
- Trial name
- ROCKS (NCT07428278)
- Testing
- ROCKS, Usual Care
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Illinois at Chicago
Cardiac Arrest, Sudden, Cardiopulmonary Resuscitation (CPR)
The Influence of the Thoracic Stiffness of CPR Teaching Manikins on the Accuracy of Compression in Cardiopulmonary Resuscitation
This study was a multicenter, prospective, randomized controlled, parallel single-blind study. The purpose of this study is to analyze the effect of compression quality by controlling the thoracic stiffness.
- Conditions
- Cardiac Arrest, Sudden, Cardiopulmonary Resuscitation (CPR), Manikins
- Trial name
- NCT07861841
- Testing
- different elasticity coefficients of the manikin device
- Where
- China
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Tang Ziren
Maternal Morbidity and Mortality
Creating VIP Corps to Reduce Maternal Deaths
The goal of this observational study is to create and rigorously evaluate a violence intervention and prevention corps (VIP Corps) training using a randomized controlled trial among undergraduate and professional students; and to…
- Trial name
- NCT06089109
- Testing
- The Big 3, Implementation and Effectiveness of VIP Corps Training
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- Ann Coker
Cancer, Death
Prostate Lung Colorectal and Ovarian (PLCO) Cancer Screening Trial
The Division of Cancer Preventionl (DCP, formerly DCPC), under extramural contracts to 10 U.S. clinical centers, is evaluating the effectiveness of screening for prostate, lung, colorectal and ovarian cancer (The PLCO Trial).
- Trial name
- NCT00339495
- Where
- United States
- Volunteers
- 154,900 people
- Sponsor
- National Cancer Institute (NCI)
Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest
Epinephrine Dose: Optimal Versus Standard Evaluation Trial
The objective of this randomized controlled trial is to evaluate whether a low cumulative dose of epinephrine ("low dose") is non-inferior to a standard cumulative dose of epinephrine ("standard dose") with respect to survival to…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia-Pulseless
- Trial name
- EpiDOSE (NCT03826524)
- Testing
- Epinephrine
- Where
- 9 sites in Canada
- Volunteers
- 1,250 people
- Sponsor
- Unity Health Toronto
Cardiac Arrest, Sudden Cardiac Arrest
Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America
The overall goal of this project is to design, develop, and pilot test an emergency healthcare drone delivery system suitable for rural communities that can deliver AEDs to out-of-hospital cardiac arrest (OHCA) locations more…
- Trial name
- RESTORe-CARE (NCT06229418)
- Testing
- DFR AED Pilot Program
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Dementia
Decoding Death and Dying in People With Dementia by Digital Thanotyping
How can healthcare professionals recognize that a person with dementia is at the end of life? When people are dying, their physical, mental, and social abilities are gradually declining.
- Trial name
- 5-D (NCT06437132)
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 270 people
- Sponsor
- University of Bergen
Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest
Mitral Valve Prolapse Arrhythmic Risk
Mitral valve prolapse (MVP) is common with a 2-3 % prevalence in the general association and generally associated with a favorable prognosis.
- Trial name
- MVP-Risk (NCT07830888)
- Testing
- Risk prediction model
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Metastatic Breast Cancer, End of Life
Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians
I this qualitative study, Investigators will conduct semi-structured interviews with clinicians that are involved in the care of patients with breast cancer to evaluate the acceptability, appropriateness, and…
- Trial name
- NCT05440929
- Testing
- Clinician Qualitative Interview
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Death Anxiety, Death Attitude (Implicit/Explicit)
Platform for End-of-life Awareness, Conversations, and Education (PEACE) Among Registered Nurses
The goal of this clinical trial is to evaluate whether the PEACE program can improve early career registered nurses' registered nurses' attitudes towards caring for palliative patients, ability to cope with patients' death, and…
- Conditions
- Death Anxiety, Death Attitude (Implicit/Explicit), End of Life Care, Advanced Care Planning (ACP)
- Trial name
- NCT07774468
- Testing
- Death Conversation, Online ACP Education
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Epilepsy, SUDEP
Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy
30% of patients with epilepsy suffer from drug-resistant seizures and have a greater risk of premature mortality than the general population.
- Trial name
- ICARE (NCT07599150)
- Testing
- SEEG monitoring, Comprehensive respiratory monitoring, Cardio-respiratory monitoring
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Sudden Infant Death
Training About Sudden Infant Death Syndrome
Sudden infant death syndrome, which constitutes a significant proportion of all infant deaths, is associated with various preventable risk factors.
- Trial name
- SIDS (NCT06922682)
- Testing
- Training with Sudden Infant Death Syndrome Training Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Mucopolysaccharidosis Type II, Metabolic Diseases
A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
This is phase 2/3 study to evaluate the safety, pharmacokinetics, pharmacodynamics, and efficacy of the investigational product GNR-055 in MPS II (Hunter syndrome) patients of different age groups.
- Trial name
- NCT05208281
- Testing
- GNR-055 1.0-2.0-3.0 mg/kg, GNR-055 2.0 mg/kg, GNR-055 3.0 mg/kg
- Where
- 5 sites in Russia
- Volunteers
- 32 people
- Sponsor
- AO GENERIUM
Sudden Infant Death
Incorporation of Safe Sleep Education Into m-Health Technology
Sudden Unexplained Infant Death (SUID) is the leading cause of death in infants age 28 days to 1 year. Protective factors, such as supine positioning, firm sleep surface, breastfeeding, pacifier use, elimination of soft objects…
- Trial name
- NCT06074211
- Testing
- Safety in Seconds mobile app: Safe Sleep Education, Safety in Seconds mobile app: Car Seat Safety Education
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Infant Death, Serious Injury
The Happiest Baby, Inc. SNOO Postmarket Surveillance Study
This postmarket surveillance study will evaluate the safety of the SNOO Smart Sleeper Bassinet when used for infants who are at high risk for Sudden Unexpected Infant Death (SUID).
- Trial name
- NCT06361303
- Testing
- SNOO Bassinet
- Where
- United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Happiest Baby, Inc.
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Organ Donor, Brain Death
Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function
Each year, only one third of patients registered on the waiting list receive a kidney transplant. Numerous paths are being explored with the aim of reversing this shortage.
- Conditions
- Organ Donor, Brain Death, Kidney Transplant; Complications, Critical Illness
- Trial name
- HYPOREME (NCT03098706)
- Testing
- Procedure control: normothermia, Procedure active
- Where
- 54 sites in France
- Volunteers
- 532 people
- Sponsor
- Nantes University Hospital