Clinical trials: Decline, Cognitive
Community-Dwelling Older Adults, Aging
The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip Strength in Community-Dwelling Older Adults: A Mixed-Methods Research
Block-building activities represent a promising tool for enhancing cognitive and hand function in older adults. When integrated with technological support, they offer personalized training advantages; however, their comprehensive…
- Conditions
- Community-Dwelling Older Adults, Aging, Cognitive Decline, Hand Dexterity
- Trial name
- NCT07315724
- Testing
- Technology-Assisted Block Training Program
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Cardiovascular Risk Factors, Age-Related Cognitive Decline
Effects of Tart Cherry Juice on the Body
Tart cherries are a rich source of antioxidants. Studies have shown that tart cherries exert anti-oxidative and anti-inflammatory properties.
- Trial name
- NCT02922920
- Testing
- Tart cherry juice
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Cognitive Decline, Cognition Disorders in Old Age
The Effect of Blueberry Supplementation on Cognitive Functioning in Older Adults
In this randomized placebo controlled intervention study, the effect of 12 weeks of supplementation with either 150g whole blueberries, freeze-dried blueberry powder (dose equivalent to 150g berries) versus placebo on cognitive…
- Conditions
- Cognitive Decline, Cognition Disorders in Old Age, Aging
- Trial name
- BrainBerries (NCT07170943)
- Testing
- Blueberry, Freeze-dried blueberry powder
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wageningen University
Cognitive Decline, Mild
Effects of Hericium Erinaceus on Microbiota and Cognition
The study evaluates the effects of Hericium erinaceus on microbiota, cognition, and other health parameters in older adults. All measurements will be performed at baseline and ten weeks after daily consumptions of either Hericium…
- Trial name
- HE (NCT04939961)
- Testing
- Hericium erinaceus
- Where
- Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Alzheimer Disease or Associated Disorder, Dementia
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
The goal of this pilot randomized controlled trial is to assess the impact of D2D rideshare services with a trained companion driver on the rate of medical appointments for older adults and individuals with AD/ADRD.
- Conditions
- Alzheimer Disease or Associated Disorder, Dementia, Cognitive Decline
- Trial name
- NCT06850870
- Testing
- Door-through-door companion rideshare, Curb-to-curb rideshare services
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Onward Health, Inc
Mild Cognitive Impairment, Subjective Cognitive Decline
Thinking About Memory: How Confident Are You in Your Memory, and Does it Change With Age?
Memory and our own beliefs and confidence in our ability to remember are important for our daily lives. For example, low confidence may hold us back from doing certain tasks, whereas misplaced high confidence in our memories may…
- Trial name
- NCT06539403
- Testing
- Memory tasks
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- King's College London
Deep Brain Stimulation, Parkinson Disease
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with…
- Trial name
- NCT06960096
- Testing
- DBS combined with fMRI
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cognitive Decline
A Supplement on Cognitive Function and Brain Activity in Middle Age and Older Healthy Adults
PoZibio™ capsules contains Lactobacillus paracasei which has been heat-killed (post-biotic). The researchers will recruit a cohort of middle aged and older adults (>50 years) who will be randomised into PoZibio™ (2 x capsules…
- Trial name
- PZAC (NCT05892627)
- Testing
- PoZibio
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Age-related Cognitive Decline, Computers, Handheld
Interest of Two Digital Devices for the Diagnosis of Neurocognitive Disorders in Elderly People With Cognitive Symptoms.
The goal of this clinical trial is to compare conventional clinical data collected as part of usual practice with data collected by the two digital tools to help diagnose major and minor neurocognitive disorders in elderly people…
- Conditions
- Age-related Cognitive Decline, Computers, Handheld, Neurocognitive Disorders
- Trial name
- NCT06032611
- Testing
- COGNUM_ALZVR
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- RIVAGES
Memory Complaint Without Cognitive Decline
GAit, MEmory, Dietary and Vitamin D
Gait and posture disorders are very common in subjects aged 65 and over, and result mainly from neuromuscular and cognitive disorders.
- Trial name
- GAME-D2 (NCT02086409)
- Testing
- Yogurt supplemented with vitamin D and calcium, Yogurt not supplemented with vitamin D and calcium
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Vestibular Function Disorder, Cognitive Decline
The Effect of Computerized Vestibular Function Assessment and Training System Combined With Cognitive/Motor Dual-task
This study aims to investigate the effect of computerized vestibular function assessment and interactive training system, combined with cognitive/motor dual-task for the elderly with dizziness.
- Conditions
- Vestibular Function Disorder, Cognitive Decline, Dizziness, Vestibular Abnormality
- Trial name
- NCT05990023
- Testing
- Traditional vestibule rehabilitation training, Dual-task vestibule rehabilitation training
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Spatial Navigation
Exploring to Remediate Behavioral Disturbances of Spatial Cognition
Spatial navigation (SN) has been reported to be one of the first cognitive domains to be affected in Alzheimer's disease (AD), which occurs as a result of progressive neuropathology involving specific brain areas.
- Trial name
- BDSC-MCI (NCT05944601)
- Testing
- Virtual and computer-based cognitive remediation training
- Where
- Italy
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Memory Problems
Brain Fitness APP for Aging With a Healthy Brain
Memory and cognitive declines are associated with normal brain aging but are also precursors to dementia, in particular the so called the pandemic of the century, Alzheimer's disease.
- Trial name
- NCT03600545
- Testing
- Brain Fitness App
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cognitive Decline, Cancer
Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment
Cancer survival rates have increased dramatically in recent years. However, many survivors report cognitive decline following treatment, which significantly impairs their quality of life.
- Trial name
- CRCI (NCT04210778)
- Testing
- Cognitive orientation to daily occupational performance (CO-OP), Computerized Cognitive Training (BrainHQ, posit science)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Subjective Cognitive Decline
REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study
Older adults with subjective cognitive decline (SCD) are at high risk of developing dementia and frequently experience subclinical symptoms (e.g., anxiety, depression) which are themselves associated with dementia and cognitive…
- Trial name
- SCD-ReCODED (NCT06429215)
- Testing
- Multi-component Intervention (MC-I): VR Cognitive training and Psychoeducation on health and lifestyle, Cognitive-only intervention (CO-I): VR Cognitive training (+ Psychoeducation active control), Active control intervention (AC-I): VR Cognitive active control + Psychoeducation active control
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Cardiovascular Health, Functional Health
Beetroot Extract and Quality of Life in Adults Aged 75 and Over
The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging.
- Conditions
- Cardiovascular Health, Functional Health, Cognitive Function Decline, Physical Performance Decline in Older Adults
- Trial name
- BERS (NCT07666685)
- Testing
- Beetroot Extract Supplementation
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Alzheimer Disease, Subjective Cognitive Decline
Technical R&D and Demonstration of Intelligent Medical Care in Alzheimer's Disease's Management
This is a study on patient registry, and the sample size of this clinicaltrial is designed in group sequential design. According to the diagnostic criteria, the subjects are divided into SCD group, MCI group and mild dementia…
- Conditions
- Alzheimer Disease, Subjective Cognitive Decline, Mild Cognitive Impairment, Mild Dementia
- Trial name
- NCT05641480
- Testing
- Transcutaneous electrical acupoint stimulation&Music therapy, Donepezil hydrochloride tablets or carpalatine bitartrate tablets
- Where
- 2 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shaanxi Hospital of Traditional Chinese Medicine
Alzheimer Disease, Cognitive Decline
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests.
- Conditions
- Alzheimer Disease, Cognitive Decline, Aging
- Trial name
- NCT04800588
- Testing
- California Cognitive Assessment Battery
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Neurobehavioral Systems, Inc.
Cognitive Decline, Mild
Predict Early Cognitive Changes in a Healthy Elderly Population by Passively Recording Sensor Data From Mobile Devices
The study will recruit 100 participants aged 65+ residing in assisted living facilities. Eligible participants will undergo an initial cognitive assessment to document their baseline cognitive status using cognitive tests…
- Trial name
- 0150-24 SOR (NCT07596186)
- Where
- Israel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center