Clinical trials: Deep Brain Stimulation, active
Parkinson Disease
Double-Blind Clinical Trial of Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease
The goal of this trial is to evaluate the preliminary safety and efficacy of programming to maximize stimulation of the dorsolateral region of the subthalamic nucleus (STN) receiving primary motor (M1) and supplementary motor…
- Trial name
- NCT06008717
- Testing
- active subthalamic nucleus deep brain stimulation plus optimal drug therapy, inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy
- Volunteers
- 40 people
- Sponsor
- Mallory Hacker
Parkinson's Disease and Parkinsonism, Dyssomnia
Sensing in Sleep Deep Brain Stimulation
Participants in this study have Parkinson's Disease and already have a device, called the Percept RC Deep Brain Stimulation device implanted.
- Trial name
- NCT07636720
- Testing
- Polysomnography ON stimulation then OFF, Polysomnography OFF stimulation then ON
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Parkinson Disease, Essential Tremor
Effects of Stimulation Patterns of Deep Brain Stimulation
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia…
- Conditions
- Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
- Trial name
- NCT02553525
- Testing
- Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Central Post Stroke Pain
Efficacy of Pain Intervention With Deep Brain Stimulation Neuromodulation
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat severe pain following a stroke in adults. It will also learn about the safety of deep brain stimulation.
- Trial name
- EPIONE (NCT06387914)
- Testing
- Stimulation ON, Stimulation Pseudo-ON
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Parkinson Disease
Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD
Our goal is to better understand how DBS modifies local neuronal activity and to pioneer device technologies that can record local DBS-evoked potentials (DLEPs) to guide therapy.
- Trial name
- NCT06169852
- Testing
- Unilateral dual-target (STN/GPi) DBS
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Essential Tremor, Deep Brain Stimulation
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Diffusion Tensor Imaging, Magnetic Resonance
- Trial name
- TREMBLE (NCT05968976)
- Testing
- Awake DBS, Asleep DBS
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Parkinson Disease, Idiopathic
The Impact of Deep Brain Stimulation on Speech and Swallow Function in Parkinson Disease
Nearly one-million people in North America are now living with Parkinson's disease (PD), and that number is projected to rise to nearly 1.2 million by 2030.
- Trial name
- NCT07026734
- Testing
- Deep brain stimulation surgery - GPi, Deep Brain Stimulation Surgery - STN
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Health Adults, Temporal Interference Stimulation
Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders
The goal of this clinical trial is to validate if temporal interference brain stimulation (TIBS) is safe in healthy volunteers aged 20 to 65.
- Conditions
- Health Adults, Temporal Interference Stimulation, Safety and Effectiveness, Crossover Study
- Trial name
- NCT07179848
- Testing
- Temporal Interference Stimulation - Treatment first
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Parkinson Disease (PD), Deep Brain Stimulation
One-Year Effect on Levodopa Equivalent Daily Dose of Thalamic VIM Nucleus Stimulation Compared to Subthalamic Nucleus Stimulation in Patients With Parkinson's Disease
This study compares the effects of deep brain stimulation (DBS) of the thalamic VIM nucleus versus the subthalamic nucleus (STN) on the levodopa equivalent daily dose (LEDD) in patients with Parkinson's disease.
- Trial name
- VIM vs NST (NCT06936254)
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Central Hospital, Nancy, France
Tremor, Essential Tremor
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System.
- Trial name
- rT DBS (NCT07049003)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Cleveland Clinic
Tourette Syndrome
Tourette Deep Brain Stimulation (DBS) Target Detection & Suppression
The investigators will implant and monitor 8 research subjects with a subcortical closed-loop system for detection and suppression of tics in subjects with medically refractory debilitating Tourette Syndrome.
- Trial name
- NCT05371041
- Testing
- Medtronic Percept Neurostimulator
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Refractory Epilepsy, Deep Brain Stimulation
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection.
- Trial name
- NCT05493722
- Testing
- Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Parkinson Disease
DBS Virtual Learning Experience
The success of Deep Brain Stimulation (DBS) is more correlated to fulfillment of patients' expectations, than merely improvement of motor status1.
- Trial name
- NCT06436313
- Testing
- Educational Sessions
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Self-Injurious Behavior, Autism Spectrum Disorder
Deep Brain Stimulation for Severe Self-Injurious Behaviour in Children
Deep Brain Stimulation for the Treatment of Severe Refractory Self-Injurious Behaviour in Children with Autism Spectrum Disorder: A Randomized Trial To evaluate the effectiveness of deep brain stimulation (DBS) of the nucleus…
- Trial name
- NCT06529380
- Testing
- DBS ON, DBS OFF
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- The Hospital for Sick Children
Parkinson's Disease (PD), Essential Tremor
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech…
- Trial name
- NCT07455760
- Testing
- Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Boston University Charles River Campus
Obsessive-Compulsive Disorder
Deep Brain Stimulation Surgery for the Treatment of Refractory Obsessive-Compulsive Disorder
This study will include two parts. The first part will include two patients in a non-blinded, non-randomized, open trial. They will undergo Deep Bran Stimulation (DBS) for OCD (targeting the amSTN), as clinically accepted and…
- Trial name
- NCT05995951
- Testing
- Deep Bran Stimulation (DBS)
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders
Lemborexant on Perioperative Sleep Quality in Patients With Parkinson's Disease Undergoing Deep Brain Stimulation
This study tests whether lemborexant, an approved sleep medicine, can improve sleep and recovery in people with Parkinson's disease undergoing deep brain stimulation (DBS) surgery.
- Conditions
- Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders, Deep Brain Stimulation
- Trial name
- NCT07903038
- Testing
- Lemborexant 5 mg, Placabo
- Volunteers
- 128 people
- Sponsor
- Beijing Tiantan Hospital
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Investigating the Increased Risk of Falls in Individuals With Parkinson's Disease Treated With Deep Brain Stimulation
The purpose of this pilot study is to assess changes in thinking and movement after deep brain stimulator implantation. The study will also examine whether these changes are related to the risk of falls.
- Trial name
- NCT07725315
- Testing
- DBS as part of standard of care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
- Trial name
- LIFUP-MCIAD (NCT05417555)
- Testing
- Low-Intensity Focused Ultrasound Pulsation (LIFUP)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Parkinson's Disease (PD)
LFP-based Parameter Prediction in DBS for Parkinson's Disease
The goal of this observational study is to assess whether deep brain stimulation (DBS) contact selection in Parkinson's disease could be informed by subcortical local field potential (LFP) recordings.
- Trial name
- NCT07485621
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Loes Laurijssen