Clinical trials: Deep Carious Lesions
Dental Caries
Pulp Protection in Selective Carious Tissue Removal
Although selective removal of carious tissue to soft dentin (SRCT-S) has been proposed as the standard of care for the management of deep dentin caries, it is unclear whether a cavity liner is necessary.
- Trial name
- PULPROTECT (NCT04250142)
- Testing
- Self-etching Adhesive, Glass Ionomer
- Where
- Chile
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Talca
Dental Caries in Children
Partial or Complete Excavation of Deep Caries in Primary Molars
Background: The traditional approach of carious lesions with risk for progression has has been to excavate all infected and demineralised tissue before placement of the restoration.
- Trial name
- PBRN (NCT04614285)
- Testing
- Partial excavation
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
DME, Dental Caries
The Effect of Bulk Filling Flowable Composite on Caries Recurrence in Deep Marginal Elevation: A Randomized Clinical Trial
Deep marginal elevation usinge a bioactive dental material in deep subgingival Class II restorations, S-PRG filler-containing materials offer significant benefits due to their bioactive properties, Their ability to release…
- Conditions
- DME, Dental Caries, Dental, Deep Margin Elevation
- Trial name
- NCT06900868
- Testing
- Assigned Interventions
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Primary Dental Caries
Effects of Partical Excavation in One Versus Two Procedures of Primary Deep Caries (PAPRICA)
Background: Deep caries is the most frequent reason for performing root canal treatments. Minimally invasive methods for the treatment of deep carious lesions might therefore be relevant to avoid pulp exposures and consequently…
- Trial name
- PAPRICA (NCT03696498)
- Testing
- Resin restoration (1 step), Resin restoration (2 steps)
- Where
- 11 sites in Denmark, Lithuania and 2 more
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Carious Dentin
Postoperative Hypersensitivity and Digital Radiographic Assessment of a Zinc Modified Versus a Conventional Glass Ionomer Cement in Deep Carious Lesion: Randomized Controlled Clinical Trial
The study aim to evaluate the difference between the effect of zinc modified glass ionomer and conventional glass ionomer on the success of partial caries removel technique
- Trial name
- NCT03285022
- Testing
- Partial caries removel techniques
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpitis in Permanent Teeth, Dental Caries Extending to Pulp
Pulp Inflammatory Markers and Outcome of Pulpotomy
This is a prospective clinical study that aims to investigate the level of inflammatory mediators in the inflamed dental pulp and its potential relationship to the outcome of full pulpotomy in mature permanent teeth with carious…
- Trial name
- pulpitis (NCT06960603)
- Testing
- Full pulpotomy
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Deep Dental Caries
Clinical Comparison of Vital Pulp Capping Restorative Protocols
At present, dentistry aims for conservative treatments with the goal of maintaining as much tooth structure as possible. Dental caries remains the most prevalent chronic disease worldwide; these lesions can progress rapidly and…
- Trial name
- NCT02635867
- Testing
- Indirect Pulp capping-Resin-modified calcium silicate - TheraCal, Indirect Pulp capping-Calcium hydroxide - Dycal, Indirect Pulp capping-Resin-based dentin bonding agent
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Patients With Deep Carious Lesions
Clinical Evaluation and Microbiological Assessment of Diode Laser and Chemical Disinfection in Comparison to Selective Caries Removal
Objectives: To evaluate the clinical and antimicrobial effect of Diode laser and chemical disinfection in comparison to selective caries removal in management of deep carious lesions.
- Trial name
- NCT03955341
- Testing
- Diode laser disinfection, Chemical disinfection using 2% Chlorhexidine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Misr International University
Dentin, Carious, Indirect Pulp Capping
Clinical Success of Indirect Pulp Capping: 1-Year Follow-Up
The goal of this clinical trial is to compare the clinical success of theracal pt, therabase, and biodentine indirect pulp capping on primary molars with deep dentin caries.
- Trial name
- NCT06325540
- Testing
- indirect pulp capping with theracal pt, indirect pulp capping with therabase, indirect pulp capping with biodentine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Dental Caries
Evaluation of the Antibacterial Effect of Laser Diode and Zinc Oxide Nano Particles in Cavity Disinfection
this is a randomized controlled clinical trial, evaluating the antibacterial effect of laser diode and zinc oxide nano-particles when used as cavity disinfectants.Two groups, including 15 patients each, will be randomly allocated…
- Trial name
- NCT03478150
- Testing
- zinc oxide nano-particles, laser diode
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Caries, Indirect Pulp Capping
Pulp Capping in Primary Molars Using TheraCal (LC)
A randomized clinical trial that aims to evaluate clinical and radiographic success rates of indirect pulp capping and direct pulp capping in primary molars with reversible pulpitis using a light-cured tri-calcium silicate base…
- Conditions
- Deep Caries, Indirect Pulp Capping, Direct Pulp Capping, Reversible Pulpitis
- Trial name
- NCT05167123
- Testing
- Light cured tri-calcium silicate base material
- Where
- 3 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Caries, Dental
Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars
Objective: To assess which is the most efficient pulpotomy medicament on tooth survival in patients with a cariously-exposed vital young permanent molar regarding: absence of postoperative pain, sinus or swelling, internal/…
- Trial name
- NCT03119779
- Testing
- MTA-Anglus, TheraCal
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Dental Caries
Randomized Clinical Trial for Primary Molar Pulpotomy, Biodentine Vs Formocresol-ZOE
This is a RCT that will compare the clinical and radiographic success of pulpotomies on primary molars between the traditional technique (Formocresol/ZOE) and the new technique with Biodentine.
- Trial name
- NCT02201498
- Testing
- Pulpotomies with Formocresol/OZE and Biodentine
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Deep Caries, Pulpitis Reversible
The Prognostic Impact of Symptoms and Lesion Depth in Partial Removal of Carious Tissue
The goal of this prospective, observational clinical cohort study is to study the effect of the preoperative condition of the tooth on the outcome of partial removal of carious tissue in mature teeth in adults.
- Conditions
- Deep Caries, Pulpitis Reversible, Pulp Hyperemia
- Trial name
- NCT05816525
- Testing
- Partial removal of carious tissue, Final restoration
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Deep Caries
Evaluation of the Remineralizing Effect of Aloe Vera Versus Diode Laser for Management of Deep Carious Lesions.
The present study will be performed to evaluate: The remineralizing effect of Aloe Vera versus Diode laser on deep carious dentin after selective caries removal.
- Trial name
- NCT05327049
- Testing
- no intervention, diode laser, Aloe Vera
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Deep Carious Lesion, Indirect Pulp Treatment
Light Cured Resin Modified Calcium Silicate Versus Light Cured Calcium Hydroxide in Indirect Pulp Treatment of Primary Molars
The objective of this study is to explore if light cured resin modified Calcium silicate could result in better clinical and radiographic success if compared to light cured Calcium hydroxide when used in indirect pulp capping…
- Trial name
- NCT03791255
- Testing
- Calcium silicate liner, Calcium hydroxide liner
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries, Dental
Alternative Treatment of Deep Carious Lesions Based on Biological Evidences
The purpose of this study is to evaluate the success rate of alternative treatment of deep carious lesions in asymptomatic primary teeth with no clinical nor radiographic signs of pulpal inflammation.
- Trial name
- NCT00973089
- Testing
- Incomplete caries removal in primary teeth
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Dental Caries, Dental Diseases
Bioactive Versus Non-Bioactive Restorative System in Deep Carious Molars
This research study delves into the effectiveness of bioactive and non-bioactive restorative systems in deep carious permanent molars treated with selective caries removal.
- Conditions
- Dental Caries, Dental Diseases, Deep Caries, Tooth Diseases
- Trial name
- NCT06348953
- Testing
- selective caries removal and conventional non-bioactive restorative system, selective caries removal and bioactive restorative system
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Caries, Ozone
Influence of Ozone Application in Stepwise Excavation Procedure of Primary Molars With Deep Carious Lesion
Purpose: The purpose of this study was to investigate the clinical and microbiological effectiveness of the ozone application in stepwise excavation of primary molars.
- Trial name
- NCT03737201
- Testing
- ozone, chlorhexidine digluconate, Control
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Caries; Dentin
SMART With Different Modifications in Asymptomatic Deep Carious Lesions of Primary Molars.
This study aimed to evaluate the clinical success of the 'Silver Modified Atraumatic Restorative Technique '(SMART) with different modifications in asymptomatic deep carious lesions of primary molars.
- Trial name
- NCT06645860
- Testing
- SDF+KI+LED Light 20s, SDF+KI
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University