Clinical trials: Deep Sedation
Pain
Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
This study is a clinical trial of moderate sedation versus deep sedation with propofol for procedural sedation in the Emergency Department.
- Trial name
- NCT02404610
- Testing
- Moderate Procedural Sedation with a sedative medication., Deep Procedural Sedation with a sedative medication., propofol
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Hennepin Healthcare Research Institute
Surgery, Hypoventilation
A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques
The estimation of the partial pressure of carbon dioxide (PCO2) in the arterial blood is used to judge the adequacy of ventilation during spontaneous and controlled ventilation.
- Trial name
- NCT00954733
- Testing
- Arterial blood draw
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Adrenal Insufficiency
Cortisol Response to Moderate and Deep Sedation in Children
Currently, it is unknown whether sedation itself induces a rise in serum cortisol levels or if cortisol levels rise under only the most invasive of procedures, regardless of the type of anesthetic agent used.
- Trial name
- NCT01265966
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Tripler Army Medical Center
Oxygen Administration During Deep Sedation
Nasopharyngeal Versus Nasal Cannula Oxygen Supplementation in Surgery Patients
The investigators plan to conduct a randomized, controlled trial comparing nasopharyngeal oxygen supplementation to traditional nasal cannula in patients undergoing oral surgery under moderate sedation.
- Trial name
- NCT02219464
- Testing
- Nasopharyngeal catheter, Nasal Cannula, Oxygen Supplementation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Hypoventilation
Ketamine Infusion and Hypoventilation
Procedures performed under sedation have the same severity in regards to morbidity and mortality as procedures performed under general anesthesia1.
- Trial name
- NCT01535976
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwestern University
Moderate, Deep Sedation
Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children
There is a wide variation of published IV ketamine dosing regimens used for procedural sedation in children in the Emergency Department (ED).
- Trial name
- NCT02519595
- Testing
- Ketamine IV 1mg/kg, Ketamine IV 1.5mg/kg, Ketamine IV 2mg/kg
- Volunteers
- 182 people
- Sponsor
- Children's Hospital of Michigan
Procedural Sedation
Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
This will be a randomized trial of propofol versus the combination of propofol and ketamine for procedural sedation for procedures in the Emergency Department (ED).
- Trial name
- NCT01260662
- Testing
- Propofol, 1:1 Propofol/Ketamine, 4:1 Propofol/Ketamine
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Hennepin Healthcare Research Institute
Procedural Sedation
Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Nonanesthesiologist administration of propofol for sedation is actually a field of growing interest for endoscopists, as demonstrated by recent American and European guidelines on this issue.
- Trial name
- MIDAPROP (NCT01428882)
- Testing
- Midazolam, Propofol
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Infante, Javier Molina, M.D.
Cerebral Palsy
Validity of Bispectral Index Monitoring During Deep Sedation
During Intramuscular botulinum toxin injections for children with cerebral palsy, immobility is essential to inject botulinum toxin to the right muscle.
- Trial name
- NCT02096549
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yeungnam University College of Medicine
Sedation
Stress During Deep Sedation With Propofol With and Without Alfentanil
This is a randomized clinical trial of deep procedural sedation with propofol with and without supplemental alfentanil. Patients will be assessed for total and fractionated serum catecholamines before and after the procedure in…
- Trial name
- NCT00997113
- Testing
- propofol, alfentanil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hennepin Healthcare Research Institute
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Brain, Sedation
Deep Brain Stimulation (DBS) Sedation
Deep brain stimulation (DBS) of different brain nuclei is a treatment for multiple brain disorders. The subthalamic nucleus (STN) and globus pallidus have been used to treat advanced Parkinson's disease for a long time.
- Trial name
- NCT03283150
- Testing
- Remifentanil, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Conscious Sedation, Deep Sedation
Effects of Two Different Sedation Regimes on Auditory Evoked Potentials and Electroencephalogram (EEG)
Sedation may be necessary in intensive care to facilitate diverse therapeutic interventions, but the use of sedative drugs may increase the risk of delirium and long-term cognitive impairment.
- Conditions
- Conscious Sedation, Deep Sedation, Critical Care
- Trial name
- NCT00641563
- Testing
- Dexmedetomidine, Midazolam, Remifentanil
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Traumatic Brain Injury
The Use of Bispectral Index Monitoring to Assess Depth of Sedation in Patients With Traumatic Brain Injury
An observational study to assess the BIS reported level of sedation of patients with traumatic brain injury in the ICU.
- Trial name
- BIS-TBI (NCT03575169)
- Testing
- BIS Monitor
- Where
- 4 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Aberdeen
Anesthesia, Deep Sedation
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Hypothesis: There is a statistically measurable correlation between qNOX and rough clinical signs of insufficient anti-nociception such as movements during Laryngeal Mask Airway (LMA) insertion, skin Incision, LMA removal.
- Trial name
- NCT02928172
- Testing
- qCON-qNOX, BIS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Atrial Fibrillation, Atrial Flutter
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion
A randomized, open-blinded, prospective study to evaluate the timeliness and safety of direct current cardioversion (DCCV) when using methohexital when compared to the more often used propofol.
- Trial name
- NCT04187196
- Testing
- Propofol, Methohexital
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Wake Forest University Health Sciences
Pain
Use of Dexmedetomidine for Deep Sedation in Patients Undergoing Outpatient Hysteroscopic Surgery
Patients undergoing deep sedation for outpatient procedures typically receive a combination of benzodiazepines, propofol, and opioids.
- Trial name
- NCT01337739
- Testing
- Active Comparator
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Northwestern University
Mental Function
Ultrasonic Deep Brain Stimulation During Anesthetic Sedation
The purpose of this study is to see if mental functions take place during different levels of anesthesia. The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia, and to…
- Trial name
- NCT05495945
- Testing
- Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI) using Propofol
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Gastrointestinal Disease
Probability Ramp Control of Propofol for EGD
Endoscopic sedation requires titration of propofol to deep sedation without minimum overshoot into general anesthesia. This skill is demanding and acquired slowly.
- Trial name
- NCT01838304
- Testing
- Probability ramp control, Monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Anesthesia
Comparison of Depth of Sedation Performance Between SedLine and Comparator Device During General Anesthesia
The primary objective is to compare the performance of Masimo's SedLine and the comparator's device systems during surgery. Relative accuracy of the individual depth of sedation indices will be compared.
- Trial name
- NCT03865316
- Testing
- SedLine Vs Comparator Test Group
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Masimo Corporation