Clinical trials: Deep Sedation, open to volunteers
Critical Illness; Mechanical Ventilation; Shock
REMIMID-ICU: Remimazolam vs Midazolam for Deep Sedation in Hemodynamically Unstable, Mechanically Ventilated Adults
This trial evaluates whether remimazolam provides superior sedation quality compared with midazolam in adults receiving invasive mechanical ventilation with ongoing vasopressor support.
- Trial name
- REMIMID-ICU (NCT07155265)
- Testing
- Remimazolam Besylate, Midazolam
- Volunteers
- 180 people
- Sponsor
- Yancheng First People's Hospital
Anesthesia, Sedation
Efficacy and Safety of Anricofen Combined With Ciprofol for Deep Sedation in Elderly Patients Undergoing ERCP
Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a key technique for treating pancreatobiliary diseases in the elderly.
- Conditions
- Anesthesia, Sedation, ERCP, Ciprofol
- Trial name
- Anricofen Cipr (NCT07376577)
- Testing
- Sufentanil, Anricofen, Ciprofol
- Where
- China
- Volunteers
- 141 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Pulsed-field Ablation, Deep Sedation
Safety And FEasibility of a Simplified Deep Sedation Protocol for Pulsed-Field Ablation
The aim of the SAFE-PFA study is to demonstrate the feasibility and safety of a simplified deep-sedation protocol for pulsed-field ablation of atrial fibrillation, with a specific focus on patient-reported outcomes.
- Conditions
- Pulsed-field Ablation, Deep Sedation, Atrial Fibrillation (AF)
- Trial name
- SAFE-PFA (NCT07633548)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Hypoxemia During Surgery
Usefulness of High-flow Oxygen Therapy of Patients at Risk of Hypoxemia Undergoing Digestive Endoscopy Under Deep Sedation
The study investigates the use of high-flow oxygen therapy devices in patients at higher risk of complications during sedated digestive endoscopies.
- Trial name
- ENDOALF-TR (NCT07439822)
- Testing
- High-flow medical oxygen insufflation, Low-flow medical oxygen insufflation
- Where
- Spain
- Volunteers
- 326 people
- Sponsor
- Outcomes'10
Sedation During Lower Extremity Surgery Under Spinal Anesthesia
Remimazolam Concentration and Sedation Depth During Lower Extremity Surgery Under Spinal Anesthesia
This study will examine how the amount of remimazolam predicted to reach its site of action relates to the depth of sedation during lower extremity surgery under spinal anesthesia.
- Trial name
- NCT07863063
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Atrial Fibrillation (AF)
A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep Sedation
Pulsed Field Ablation (PFA) has created a 'paradigm shift' within cardiac electrophysiology and the initial experience demonstrates that PFA is safe, rapid and effective compared to both radiofrequency ablation and cryoablation…
- Trial name
- CONSCIOUS-PFA (NCT07900685)
- Testing
- Catheter ablation, Deep sedation with midazolam and fentanyl or midazolam and remifentanil, Sedation with midazolam and fentanyl
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- East Sussex Healthcare NHS Trust
Capnography
The Effect of Oxygen Flow Rate on End-tidal CO2 During Deep Sedation
This study aims to detect the effect of different O2 flow rates on end tidal carbon dioxide level in patients scheduled for minor gynaecological procedures under deep sedation using laryngeal mask airway.
- Trial name
- NCT06824610
- Testing
- capnography
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Minia University
Benign Prostate Hypertrophy(BPH)
Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia
The primary aim of the study is to show that methoxyflurane-lorazepam-percocet combination administrated 'per os' is non inferior to deep intravenous sedation in achieving analgesia during Rezum convective radiofrequency water…
- Trial name
- NCT07017452
- Testing
- Methoxyflurane - Penthrox, Control, Percocet Pill
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Deep Sedation, Non-invasive Ventilation Support
Comparison of Nasal Continuous Positive Airway Pressure (CPAP) Mask and Nasal Airway in Molar Tooth Extraction Under Deep Sedation
In patients with high levels of fear and anxiety, it is recommended to perform dental procedures under sedation or general anesthesia depending on the nature of the procedure.
- Conditions
- Deep Sedation, Non-invasive Ventilation Support, Nasal Airway, Nasal CPAP Mask
- Trial name
- NCT06436638
- Testing
- Non-invasive ventilation support equipment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gözde Nur Erkan
Light, Anesthesia
Light and Anesthesia
The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include: Does light condition affect the…
- Conditions
- Light, Anesthesia, Sedation
- Trial name
- NCT07517484
- Testing
- eye mask
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University People's Hospital
ARDS, Human
Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis
Investigation of the feasibility of monitoring processed transcutaneous electroencephalography (EEG), a method of interpreting brain activity, and near-infrared spectroscopy (NIRS), a method of determining levels of tissue…
- Trial name
- NCT05847634
- Testing
- Masimo O3 NIRS cerebral oximetry and SedLine processed EEG
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Emergence Delirium in Pediatric Anesthesia
The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn Patients
The aim of this study is to compare the effects of dormicum-ketamine versus dexmedetomidine on postoperative emergence delirium in pediatric patients undergoing deep sedation for burn-related procedures
- Trial name
- NCT07519863
- Testing
- Midazolam + Ketamine, Dexmedetomidine (DEX)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Anesthesia, Sedation and Analgesia
Prospective IR-led Sedation Feasibility
This study wants to see if some interventional radiology (IR) procedures can be done without using general anesthesia. General anesthesia needs a lot of staff and equipment. It can also cause side effects.
- Conditions
- Anesthesia, Sedation and Analgesia, Interventional Radiology
- Trial name
- NCT07443254
- Testing
- ketamine, Fentanyl (IV), Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CAMC Health System
Biliary and Pancreatic Diseases, Endoscopic Retrograde Cholangiopancreatography (ERCP)
Effect of Deep Analgosedation vs. Endotracheal Intubation General Anesthesia on on Perioperative Sedation Related Adverse Events in Elderly ERCP Patients
This study aims to investigate the impact of deep analgosedation versus endotracheal intubation general anesthesia on perioperative sedation related adverse events in elderly ERCP patients.
- Trial name
- NCT07017283
- Testing
- Tracheal intubation general anesthesia, Nasopharyngeal airway ventilation
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Gang Chen
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Supraglottic Oxygenation Via Oral Transtracheal Catheter for Reducing the Incidence of Hypoxemia During ERCP Under Sedation
Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used for the diagnosis and treatment of pancreatobiliary diseases.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07637721
- Testing
- The Supraglottic Oxygenation Via Oral Transtracheal Catheter Group, The Regular Nasal Cannula
- Where
- 3 sites in China
- Volunteers
- 410 people
- Sponsor
- Zhejiang University
The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation
Modeling and Closed-loop Control of Depth of Anaesthesia
The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing…
- Trial name
- NCT03569839
- Testing
- Propofol
- Where
- Slovenia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Neuromuscular Blockade, Delayed Emergence From Anesthesia
Sugammadex Timing and Recovery Profile in Pediatric Adenotonsillectomy
Sugammadex is routinely used to reverse rocuronium-induced neuromuscular blockade in children. In clinical practice, it is given either while the child is still deeply anesthetized or after the anesthetic has lightened.
- Conditions
- Neuromuscular Blockade, Delayed Emergence From Anesthesia, Emergence Agitation
- Trial name
- SUGA-PED (NCT07902193)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Namik Kemal University
Atrial Fibrillation, Atrial Fibrillation, Paroxysmal or Persistent
Deep Sedation in Catheter Ablation of Atrial Fibrillation
The current practice of anesthesia for atrial fibrillation catheter ablation （CA） procedure is inconsistent, including general anesthesia, deep sedation, and conscious sedation.Due to the nature of deep sedation, it has been…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation, Paroxysmal or Persistent, Deep Sedations, Conscious Sedation
- Trial name
- PRIORI-AF (NCT06836999)
- Testing
- deep sedation, Conscious sedation
- Where
- 16 sites in China
- Volunteers
- 1,334 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Deep Sedation, High Flow Nasal Canula
HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy
For Patients and Families This study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation.
- Conditions
- Deep Sedation, High Flow Nasal Canula, Cerebral Oxygenation, PSI
- Trial name
- NCT07630038
- Testing
- High-Flow Nasal Oxygen 40 L/min (HF40), High-Flow Nasal Oxygen 55 L/min (HF55), High-Flow Nasal Oxygen 70 L/min (HF70)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Firat University
Hypoxia, Pulmonary Nodule
The Efficacy and Safety of the Supraglottic Oxygenation Via Nasotracheal Intubation for Deep Sedation Fiberoptic Bronchoscopy
Bronchoscopy is now widely used for the diagnosis and treatment of various respiratory diseases. However, the procedure is highly stimulating and provokes a strong stress response; because the airway is shared, patients are prone…
- Conditions
- Hypoxia, Pulmonary Nodule, Pulmonary Infection
- Trial name
- NCT07389083
- Testing
- wire-reinforced tracheal tube
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Zhejiang University