Clinical trials: Defects
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
An Integrative-"Omics" Study of Cardiomyopathy Patients for Diagnosis and Prognosis in China
This is a multi-omics research of Chinese cardiomyopathies patients, aiming to determine genetic risk factor and serial biomarkers of cardiomyopathies in diagnosis and prognosis.
- Conditions
- Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, Left Ventricular Non-compaction
- Trial name
- AOCC (NCT03076580)
- Where
- 3 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Intrabony Periodontal Defect
Efficacy of Titanium Granules in the Treatment of Periodontal Intrabony Defects
The ideal goal of the periodontal treatment is not only to prevent the progression of the disease, but also the regeneration and reconstruction of lost tissues.
- Trial name
- NCT04932161
- Testing
- Titanium Granules, Hydroxyapatite
- Where
- India
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Meningomyelocele
Stress-associated Epigenetic Alterations in Newborns After Fetal Surgery
Open spina bifida or myelomeningocele (MMC) is a devastating congenital defect of the central nervous system for which there is no cure. The etiology of MMC remains poorly understood.
- Trial name
- NCT04027374
- Testing
- Fetal surgery for MMC repair
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Furcation Defects
Piezosurgery in the Treatment of Class II Furcation Involvement
The purpose of this study is to evaluate the effectiveness of piezosurgery in the treatment of class II furcation involvement using biomaterials and new surgical techniques
- Trial name
- NCT02132806
- Testing
- Piezosurgery with biomaterial mp3 + bracket, Piezosurgery with biomaterial mp3, Piezosurgery
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Matteo Visintin
Congenital Heart Disease
Transition Care Model for Adolescents With Congenital Heart Disease
The primary aim of this study is to assess the effectiveness of a standardized transition care model (TC) on the perceived mental and physical health of adolescents with congenital heart disease (CHD).
- Trial name
- TELEMACO (NCT05713591)
- Testing
- Transition care model
- Where
- Italy
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Human Experimentation (Human Volunteers)
Evaluation of Possible Effects on the QT/ QTc Interval of Rupatadine in Healthy Volunteers
This phase I trial will evaluate the effects of rupatadine, at a dose of 10 mg OD (authorised and marketed dose) and the 100mg/day (supratherapeutic dose) on the ECG parameters with a special focus on its effect on cardiac…
- Trial name
- NCT00199225
- Testing
- Rupatadine, moxifloxacin, Continous electrocardiographic register
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- J. Uriach and Company
Periodontitis
Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans
Inflammatory periodontal disease often results in loss of bone around the teeth. Bone defects that have a certain size and shape (called intrabony or intraosseous defects) may be improved by using a graft material in the bony…
- Trial name
- NCT02154906
- Testing
- DFDBA, autologous platelet rich fibrin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Periodontal Diseases
Amnion-Chorion Allograft Barrier Used for Root Surface and Guided Tissue Regeneration
The purpose of this pilot project is to evaluate the efficacy of application of Amnion-Chorion allograft membrane on the root surface of periodontally diseased teeth in conjunction with bone substitute covered by Amnion-Chorion…
- Trial name
- NCT03095976
- Testing
- Amnion-Chorion allograft membrane on the root surface of periodontally diseased site.
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Indiana University
Regenerative Inflammation
Evaluation of Platelet Rich Fibrin Matrix as Regenerative Material in Intraosseous Defects
Technological advancement has led to the development of concentrated platelets, by means of centrifugation, popularly known as Platelet concentrates which seem to be a convenient approach to obtain autologous growth factors.
- Trial name
- NCT03616925
- Testing
- Platelet Rich Fibrin Matrix kit, surgical open flap debridement
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Preterm, Patent Ductus Arteriosus
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates.
- Conditions
- Preterm, Patent Ductus Arteriosus, Sepsis, Asphyxia
- Trial name
- CE-NeoDoppler (NCT06646250)
- Testing
- NeoDoppler - CE certified
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children
This study aims to compare the effectiveness of intraosseous and infiltration anesthesia techniques administered using a computer-assisted anesthesia device (SleeperOne® 5; Dental HiTec, France) during restorative treatments of…
- Trial name
- MIH (NCT07352813)
- Testing
- Intraosseous anaesthesia using a computerized system, Infiltration anaesthesia using a computerized system
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Intrabony Periodontal Defect
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone.
- Trial name
- NCT04896450
- Testing
- Guided tissue regeneration (GTR), Orthodontic tooth movement (OTM)
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Chronic Periodontitis
Atorvastatin in the Treatment of Mandibular Degree II Furcation Defects
ABSTARCT Background: Atorvastatin is an inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Lately, it has shown to have anti-inflammatory and bone stimulatory effects.
- Trial name
- NCT02386033
- Testing
- Atorvastatin (ATV)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Molar Incisor Hypomineralization
Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment.
- Trial name
- NCT07389148
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Molar Incisor Hypomineralization
Comparing CAD/CAM vs Composite for Carious Hypomineralized Molars Evaluating Clinical Outcomes of Both Treatments.
Molar Incisor Hypomineralization (MIH) is enamel hypomineralization defined as qualitative defects caused by disruptions in either the calcification or maturation phases of amelogenesis affecting one or more first permanent…
- Trial name
- NCT07049016
- Testing
- restoring the MIH affected young permanent molars using Direct nanohybrid flowable composite, restoring the MIH affected young permanent molars using IPS e.max CAD
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Alveolar Ridge Augmentation
Enhancing Guided Bone Regeneration by Modifying a Resorbable Membrane
Guided bone regeneration (GBR) procedures have significantly evolved over the last 20 years. Significant advances have been made with various barrier membranes with or without the use of bone grafts and other materials.
- Trial name
- NCT02396056
- Testing
- BioMend Extend, Modified BioMend Extend
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Chronic Periodontitis
Autologous Alveolar Bone Marrow Mesenchymal Stem Cells for the Reconstruction of Infrabony Periodontal Defects
Systemically healthy periodontitis patients are recruited from new referrals to the Department of Periodontology and Biology of Implants, AUTh.
- Trial name
- PerioRegen (NCT02449005)
- Testing
- BM-MSCs/fibrin glue/collagen fleece, Fibrin glue/collagen fleece, Open flap debridement
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spina Bifida, Anencephaly
Study of Genetic Risk Factors for Spina Bifida and Anencephaly
The purpose of this study is to describe the genetic contribution to the neural tube defects spina bifida (SB) and anencephaly (A), which includes identifying patients, defining the roles of certain genes, and studying…
- Trial name
- SBRR (NCT00031122)
- Testing
- No Intervention
- Where
- 2 sites in United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Heart Defects, Congenital
Accelerated Aging in Newborns and Adults With Congenital Heart Disease
Many childhood-onset diseases used to be lethal. Improved life expectancy yield that most patients can survive into adulthood, to date.
- Trial name
- AccelerAGE (NCT05667870)
- Where
- 2 sites in Belgium
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Intrabony Periodontal Defect
Regeneration of Intrabony Defects With Nano Hydroxyapatite Graft, and Periosteum as Barrier Membrane Under Magnification
The prospective study is a interventional study to evaluate and compare the effectiveness of periosteal pedicle as grafting technique and egg shell derived nano hydroxyapatite as regenerative graft material for regeneration of…
- Trial name
- NCT04195295
- Testing
- Regeneration of Intrabony Defects with Nano Hydroxyapatite Graft, Derived from Egg Shell along with Periosteum as Barrier Membrane, Regeneration of intrabony defects using Egg shell derived nano hydroxyapatite (EnHA) as regenerative graft material, Open flap debridement procedure in intrabony defects.
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital