Clinical trials: Defects
Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm
Fetal and Neonatal Magnetophysiology
Fetal research and clinical practice has been hampered by a lack of suitable investigational techniques. Currently, ultrasound is the only widely used method of studying fetal anatomy and physiology, but it has significant…
- Conditions
- Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm, Long QT Syndrome
- Trial name
- NCT01903564
- Testing
- magnetocardiography, postnatal ECG, fetal echocardiography
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Single-ventricle, Fontan Procedure
Hemodynamic, Vascular and Muscular Parameters of Exercise Capacity in Single-Ventricle Patients With Fontan Procedure
After the Fontan procedure applied in patients with a functional or anatomical single ventricle, patients are faced with significant morbidity and mortality risk.
- Conditions
- Single-ventricle, Fontan Procedure, Hemodynamic Instability, Arterial Stiffness
- Trial name
- NCT05011565
- Testing
- Demographic and Clinical Characteristics, Maximal Exercise Capacity, Submaximal Exercise Capacity, Hemodynamic Parameters, Muscle Strength, Muscle Oxygenation, Vascular Function
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Neural Tube Defects
Efficacy of Weekly Versus Daily Folic Acid Supplementation
Investigate the efficacy of weekly versus daily of folic acid supplementation on improving folate, vitamin B12,
- Trial name
- NCT00394862
- Testing
- multivitamin
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Emory University
Periodontal Diseases
Minimally Invasive Surgical Technique in Management of Intrabony Defects
In the fast-growing era of contemporary periodontology, the understanding of biological concepts in wound healing together with the evolution of the flap design and biomaterials applied in periodontal regeneration allowed for…
- Trial name
- NCT06591416
- Testing
- minimally invasive surgical technique, minimally invasive surgical technique with granulation tissue preservation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
RASopathy, Costello Syndrome
Solid Tumors in RASopathies
RASopathies are a group of syndromes, caused by variants of genes involved in the regulation of the Ras/MAP/ERK pathway. This intracellular transduction pathway profoundly affects embryogenic development, organogenesis, synaptic…
- Conditions
- RASopathy, Costello Syndrome, Cardio-Facio-Cutaneous Syndrome, Noonan Syndrome
- Trial name
- 4218 (NCT05761314)
- Testing
- Molecular characterization of solid tumor in RASopathies
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Researcher-Subject Relations
Growth and Development of Children With Congenital Heart Disease (CHD)
The Effect of Individualized Nutrition Training Given to the Families of Children with Congenital Heart Disease (CHD) in the Post-Operative Period on their Growth and Development This study was conducted experimentally to…
- Trial name
- CHD (NCT04903964)
- Testing
- family-centered nutrition education
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Primary Ciliary Dyskinesia
A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults
The goal of this observational study is to characterize clinical measures and biomarkers of airway disease in adults with primary ciliary dyskinesia (PCD) and in a group of healthy volunteers (HV) to establish normative values.
- Trial name
- NCT05685186
- Testing
- Spirometry, Multiple Breath Washout (MBW), Mucociliary Clearance (MCC)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- ReCode Therapeutics
Cancer, Cardiac Anomaly
Using NPT to Evaluate Providing PPC as ELNEC-PPC WBT for Nurses
The purpose of this study is to explain the provision of palliative care at the end of life by the implementation of the ELNEC course, as WBT Program using the Normalization Process Theory, that focus attention on how complex…
- Conditions
- Cancer, Cardiac Anomaly, Cystic Fibrosis, Muscular Dystrophy
- Trial name
- ELNEC-PPC (NCT04461561)
- Testing
- end-of-life nursing education consortium-pediatric palliative care as web based-training plus usual care
- Where
- Iraq
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Altoosi University College
Intrabony Defects in Chronic Periodontitis
Locally Delivered 1% Metformin Gel in the Treatment of Intrabony Defects in Chronic Periodontitis
This study was designed as a randomized, controlled clinical trial to evaluate the efficacy of 1% MF gel as local drug delivery in adjunct to SRP for the treatment of intrabony defects in chronic periodontitis in comparison with…
- Trial name
- NCT02048761
- Testing
- 1 % Metformin gel
- Where
- India
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Migraine Headache, PFO - Patent Foramen Ovale
Migraine With Aura and Patent Foramen Ovale: Identification of Biomarkers to Select Patients In Whom Intervention Would Be Beneficial (MANET)
This is a multicenter prospective observational study aimed to asses whether a specific prothrombotic platelet phenotype can discern migraine patients with PFO (patent forame ovale) - related symptoms from patients with…
- Trial name
- MANET (NCT06046508)
- Testing
- blood samples collection
- Where
- 3 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Patent Ductus Arteriosus
Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus
To compare efficacy and safety of paracetamol and ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in preterm infants.
- Trial name
- NCT06152796
- Testing
- Paracetamol, Ibuprofen
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Assiut University
Molar Incisor Hypomineralization
Effectiveness of Pulpotomy in Carious First Permanent Molar
Pediatric dentists frequently encounter deeply carious young permanent first molars (PFM) with Molar Incisor Hypomineralisation (MIH).
- Trial name
- NCT06137391
- Testing
- Vital Pulp Therapy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Chronic Periodontitis
Platelet-rich Fibrin With 1.2% Rosuvastatin in Chronic Periodontitis Treatment
The present study is designed to evaluate the combined efficacy of Platelet Rich Fibrin (PRF) and 1.2% Rosuvastatin (RSV) with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis patients
- Trial name
- NCT02645227
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with PRF and 1.2% Rosuvastatin
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Intrabony Periodontal Defect
Advanced Platelet Rich Fibrin in Periodontal Angular Defects
The aim of this study is to clinically and radiographically evaluate the efficacy of advanced platelet-rich fibrin (A-PRF) when used with biphasic alloplast in the management of intrabony defects in patients with moderate to…
- Trial name
- NCT03433066
- Testing
- Advanced platelet-rich fibrin mixed with biphasic alloplast, Biphasic alloplast mixed with saline
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Periodontitis
Regeneration of Human Intrabony Defects With rhFGF-2/HA
BACKGROUND: Periodontal disease is an infection that results in progressive loss of dental support, which may lead to tooth loss..
- Trial name
- NCT02337166
- Testing
- a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate, Periodontal flap surgery
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Molar Incisor Hypomineralization
Interventions to Control Hypersensitivity Pain in Teeth With Insisive Molar Hypomineralization
Molar incisor hypomineralization (MIH) manifests as a qualitative, demarcated defect in tooth enamel of systemic origin, predominantly affecting one or more permanent first molars, and potentially extending to the incisors.
- Trial name
- LBIARHMI (NCT06426108)
- Testing
- Fluoride Varnishes, Low-Intensity Laser 1J, Low-Intensity Laser 2J
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Molar-Incisor Hypomineralisation
Silver Diamine Fluoride in Molar-Incisor Hypomineralisation
The objective of this study is to assess the efficacy of silver diamine fluoride application in molars affected by molar-incisor hypomineralization.
- Trial name
- NCT06165042
- Testing
- glass hybrid restorative system, Fluoride varnish + Glass hybrid restorative system
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Marmara University
Turner Syndrome
Sex Differences in Early Brain Development; Brain Development in Turner Syndrome
Relative risk for many psychiatric disorders differs dramatically in males and females. Early-onset disorders, such as autism, occur more often in males; other conditions, such as schizophrenia, occur at similar rates in males…
- Trial name
- NCT00877942
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Ischemic Brain Injury, Stroke
Clinical Proteomic Research for the Brain
The study of plasma and urine proteomic profiles in patients with ischemic brain injury is important to better understanding of the mechanisms by which thrombolytic agents or other therapy affects clinical outcomes.
- Conditions
- Ischemic Brain Injury, Stroke, Healthy Individual, Patent Foramen Ovale (PFO)
- Trial name
- "CPR Brain" (NCT00983723)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital