Clinical trials: Defects
Periodontal Bone Loss
Decortication With Calcium Phosphosilicate Putty in the Treatment of Non-contained Intrabony Periodontal Defects
To overcome the disadvantage of complex morphology and availability of less favorable support to retention of graft and clot stabilization in 1-, 1-2-wall periodontal defects, it was hypothesized that placement of CPS putty…
- Trial name
- NCT03435757
- Testing
- OFD+IMP+CPS, OFD+IMP
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Spina Bifida and Anencephaly
Dosage Effects of Folic Acid on Blood Folates of Honduran Women
CDC staff at the National Center on Birth Defects and Developmental Disabilities have been working closely with a Honduras-based organization, Project Healthy Children (PNS) and the Ministry of Health, on a folic acid…
- Trial name
- NCT00207532
- Testing
- folic acid
- Where
- Honduras
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Molar Incisor Hypomineralization
Sealants in Molars Affected by Molar-Incisor Hypomineralization
Aim: To evaluate the clinical survival of fluoride sealants applied in first permanent molars affected by Molar-Incisor Hypomineralization (MIH).
- Trial name
- NCT02794116
- Testing
- Conventional Sealants, Resin Sealants
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Paraná
Gingival Recession
OrACELL™ vs. Connective Tissue in Miller Class 3 Defects
The purpose was to compare root coverage outcomes between autogenous connective tissue graft (CTG) and decellularized human dermis (OrACELL™) in areas of facial gingival recession.
- Trial name
- NCT03226600
- Testing
- OrACELL, Connective Tissue Graft
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Turner Syndrome, Hypogonadism
Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
Estrogen is necessary for feminization during puberty and to decrease bone resorption, the latter critical for the achievement of peak bone mass and normal bone health in the female.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00837616
- Testing
- 17 B estradiol orally, 17 B estradiol
- Where
- 3 sites in United States, Chile
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Congenital Heart Disease
Infant Nasal Nitric Oxide Levels in Congenital Heart Disease
This pilot study aims to measure nasal nitric oxide (nNO) in a group of neonates and infants (≤ 12 months) with congenital heart disease (CHD) and compare their nNO levels to age matched controls without CHD.
- Trial name
- NCT02551107
- Testing
- Measurement of nasal Nitric Oxide level
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Limb Defects
Fasciocutaneous Flaps for Leg Defects
The purpose of this study is to determine the effects of fasciocutaneous flaps for leg defects.
- Trial name
- NCT01278836
- Testing
- fasciocutaneous flap
- Where
- Iran
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Heart Defects, Congenital
Accelerated Aging in Newborns and Adults With Congenital Heart Disease
Many childhood-onset diseases used to be lethal. Improved life expectancy yield that most patients can survive into adulthood, to date.
- Trial name
- AccelerAGE (NCT05667870)
- Where
- 2 sites in Belgium
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Molar Incisor Hypomineralization
Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical Study
The aim of this study was to present a comparative evaluation of the long-term efficacy of fluoride varnish( Flúor protector), Clinpro™ White Varnish and pastes containing CPP-ACP in the remineralization of creamy-white and…
- Trial name
- NCT06362681
- Testing
- Fluoride
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Arrhythmogenic Right Ventricular Cardiomyopathy
National ARVC Data Registry and Bio Bank
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited condition that may cause life threatening irregular heart rhythms that often manifest as unexpected cardiac arrest or sudden death in early adulthood.
- Trial name
- ARVCRegistry (NCT01804699)
- Where
- 16 sites in Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Single-ventricle, Fontan Circulation
Venous Compression in Fontan
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1.
- Trial name
- NCT07220226
- Testing
- Lower extremity compression garments, Without compression garments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Migraine, Patent Foramen Ovale
GORE® CARDIOFORM Septal Occluder Migraine Clinical Study
Multi-center, prospective, randomized, placebo- and sham-controlled study to evaluate the GORE® CARDIOFORM Septal Occluder for migraine headache relief
- Conditions
- Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
- Trial name
- RELIEF (NCT04100135)
- Testing
- Actual device PFO closure, Thienopyridine (clopidogrel or prasugrel)
- Where
- 15 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- W.L.Gore & Associates
Conotruncal Cardiac Defects
Conotruncal Cardiac Defects and Nutrigenetic Etiopathogeny
The investigators planned to study the etiopathogenic factors of conotruncal cardiac defects regarding the relations between the metabolic, the genetic and the environmental factors which lead to these cardiopathy.
- Trial name
- CCOMET (NCT01460316)
- Testing
- Bood sampling for biochemicals and genetic analysis
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Molar Incisor Hypomineralization
Evaluation of Three Different Minimally Invasive Techniques for Management of Enamel Opacities in Patients With Molar Incisor Hypomineralization "Randomized Controlled Clinical Trial"
The controlled clinical trial will be done to evaluate Resin infiltration, Resin modified glass ionomer varnish and Light cured giomer varnish as minimally invasive techniques for management of enamel opacities of patients with…
- Trial name
- NCT06135272
- Testing
- Resin infiltration, Resin modified glass ionomer varnish, Light cured giomer varnish
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Molar Incisor Hypomineralization
The Effect of Molar Incisor Hypomineralisation on the Stomatognathic System
This study aims to examine whether children with Molar Incisor Hypomineralization (MIH) are more likely to have problems with the jaw joint and chewing muscles.
- Trial name
- NCT06951139
- Testing
- Ultrasound and Shear Wave Elastography
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ozge Gungor
Heart Defects, Congenital
Impact of Congenital Heart Disease on Neurodevelopmental Outcome
The project aims toward clarifying the underlying mechanism and the long-term impact of congenital heart disease on neurodevelopment.
- Trial name
- NCT03871881
- Testing
- Magnetic Resonance Imaging, Neuropsychological assessment
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Smith Lemli Opitz Syndrome, CHILD Syndrome
Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism
Background: Smith-Lemli-Opitz Syndrome (SLOS) is a genetic disorder. It can cause birth defects and developmental delays. There is no cure for SLOS or other inherited diseases related to cholesterol production or storage.
- Conditions
- Smith Lemli Opitz Syndrome, CHILD Syndrome, Lathosterolosis, Desmosterolosis
- Trial name
- NCT05047354
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Periodontitis
Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of…
- Trial name
- NCT03804086
- Testing
- Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement, Open flap debridement
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hadeer Ashraf Hassan Roushdy
Fluorosis, Dental, Fluorosis
Design of a Multicomponent Intervention to Reduce the Risk of Exposure Fluorine
Introduction Systemic exposure to fluoride is a significant challenge for global public health; this is because although fluoride prevents dental caries, prolonged exposure to high concentrations can cause adverse effects on…
- Trial name
- NCT07232888
- Testing
- multicomponent intervention, Conventional intervention
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio Nariño
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya