Clinical trials: Defects
Finger Injuries, Soft Tissue Injuries
Repair of Multiple Finger Defects Using the Dorsal Homodigital Island Flaps
Multiple finger defects are common in hand trauma and result in functional disability. These injuries are often complex and severe, and thus reconstructive alternatives are limited.
- Trial name
- NCT01767727
- Testing
- Soft tissue coverage
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Tangshan
Gingival Recession, Localized
Tuberosity Versus Palatal Connective Tissue Graft on the Treatment of Single Maxillary Recession-type Defects
The goal of this randomized clinical study is to assess the root coverage outcomes and patient morbidity following the treatment of single maxillary recession-type defects using a coronally advanced flap (CAF) combined with a…
- Trial name
- NCT06404762
- Testing
- tSCTG+ CAF, pSCTG+ CAF
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
The Presence of Horizontal and Vertical Alveolar Defects in Both Jaws, Inadequate for the Placement of at Least Two Fixtures, Even ≤6 mm Long Ones
Guided Bone Regeneration With Custom Made Meshes
Twenty patients underwent a guided bone regenerative procedure with the application of a virtually projected customized mesh as containment and stabilizer of particulate bone graft.
- Trial name
- NCT04942223
- Testing
- guided bone regeneration
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Mandibular Diseases, SSM
Virtual Anatomical Reconstruction of Mandibular Bone Defects Using a Statistical Shape Model
Hundred already taken CT-scans (50 male and 50 female) will be anonymized. These scans will be segmented and implemented into a statistical shape model that will be used to predict missing hard tissue of a mandible based on the…
- Trial name
- NCT04475237
- Testing
- CT-scan evaluation and segmentation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CADskills
Volume Defects in the Mid-face
To Evaluate the Effectiveness and Safety of YVOIRE Y-Solution 720 Injected Into the Mid-Face
To Evaluate the Effectiveness and Safety of YVOIRE Y-Solution 720 Injected Into the Mid-Face
- Trial name
- NCT04437745
- Testing
- YVOIRE Y-Solution 720
- Where
- China
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- LG Chem
Periodontal Diseases
Treatment of Periodontal Intrabony Defects With A-PRF or OFD
The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) toped flap debridement (OFD) in periodontitis patients.
- Trial name
- NCT04823572
- Testing
- A-PRF/OFD
- Where
- Hungary
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Three Wall Intrabony Defects in Chronic Periodontitis
Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis
The purpose of the present study was to investigate the efficacy of autologous Platelet rich fibrin (PRF) or PRF and Simvastatin (SMV) with open flap debridement (OFD) in the treatment of three wall intrabony defects in…
- Trial name
- NCT02120872
- Testing
- Platelet rich fibrin and simvastatin, Platelet rich fibrin, Open Flap Debridement alone
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Cornea
Healing of Persistent Epithelial Defects
The purpose of this study is to compare the relative efficacy of four different treatment modalities (i.e. aggressive lubrication, bandage contact lens, Ambiodisk amniotic membrane, Prokera amniotic membrane) in the healing of…
- Trial name
- NCT02395952
- Testing
- carboxymethylcellulose sodium, Acuvue Oasys Bandage Contact Lens, Ambiodisk
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Single-ventricle, Congenital Heart Disease
Correlation Between 3D Echocardiography and Cardiopulmonary Exercise Testing in Patients With Single Ventricle
Congenital heart disease (CHD) is the leading cause of birth defects, with an incidence of 0.8%. Among CHD, univentricular heart disease or "single ventricle" is rare and complex.
- Trial name
- VU3D (NCT05118152)
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Molar Incisor Hypomineralization
Interventions to Control Hypersensitivity Pain in Teeth With Insisive Molar Hypomineralization
Molar incisor hypomineralization (MIH) manifests as a qualitative, demarcated defect in tooth enamel of systemic origin, predominantly affecting one or more permanent first molars, and potentially extending to the incisors.
- Trial name
- LBIARHMI (NCT06426108)
- Testing
- Fluoride Varnishes, Low-Intensity Laser 1J, Low-Intensity Laser 2J
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Ehlers-Danlos Syndrome, Stickler Syndrome
Studies of Heritable Disorders of Connective Tissue
Background: Heritable disorders of connective tissue are genetic conditions that can affect the skin and other parts of the body. They are related to mutations in genes that are responsible for building tissues.
- Conditions
- Ehlers-Danlos Syndrome, Stickler Syndrome, Marfan Syndrome
- Trial name
- NCT00270686
- Where
- United States
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Congenital Heart Disease
Mechanisms of Dysfunction and the Influence of Exercise on Cardiac and Musculoskeletal Function
Primary Objective: To determine if impairments in cardiac and musculoskeletal function and metabolism exist in Fontan children. Secondary Objectives: 1. To determine if impairments do exist, are they related to exercise capacity.
- Trial name
- NCT02004756
- Testing
- Exercise Program
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Turner Syndrome, Klinefelter Syndrome
X-chromosome Inactivation, Epigenetics and the Transcriptome
The human genetic material consists of 46 chromosomes of which two are sex chromosomes. The sex-chromosome from the mother is the X and from the father the Y-chromosome.
- Conditions
- Turner Syndrome, Klinefelter Syndrome, Triple X Syndrome, 47 XYY Syndrome
- Trial name
- NCT01678261
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Furcation Defects, Periodontitis
Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in…
- Conditions
- Furcation Defects, Periodontitis, Alveolar Bone Loss Beyond Furcation
- Trial name
- NCT01522131
- Testing
- bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cortico Basal Degeneration, Corticobasal Syndrome
Imaging Studies in Corticobasal Syndrome
The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other.
- Conditions
- Cortico Basal Degeneration, Corticobasal Syndrome, Corticobasal Syndrome(CBS), Corticobasal Degeneration
- Trial name
- I-CAN (NCT07000851)
- Testing
- C-11 ER176 Radiotracer, C-11 PiB, AV1451 Tau
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jennifer Whitwell
Furcation Defects, Periodontal Diseases
Mandibular Furcation II Regeneration
Teeth with furcation grade II defects will be treated with open flap debridement and regenerative therapy with biphasic calcium phosphate combined with either enamel matrix proteins or a collagen membrane.
- Trial name
- FURC-II-REGEN (NCT04059445)
- Testing
- Biphasic calcium phosphate (Straumann Bone Ceramic) + collagen membrane (Straumann Jason Membrane), Biphasic calcium phosphate (Straumann Bone Ceramic) + enamel matrix proteins (Straumann Emdogain)
- Where
- Norway
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Turner's Syndrome
Turner Syndrome: Genotype and Phenotype
This study examines the clinical and genetic factors related to Turner syndrome, a disorder of the sex chromosomes. Humans usually have 23 pairs of chromosomes-thin strands of DNA-in the nucleus of every cell, which contain genes…
- Trial name
- NCT00006334
- Where
- United States
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Molar Incisor Hypomineralisation, Enamel Breakdown
Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH)
Cheese molars (MIH) can be recognized not only by their colour abnormalities but also by the enamel breakdown. Clinical management of those teeth may become challenging by the chronic hypersensitivity, that makes various steps…
- Conditions
- Molar Incisor Hypomineralisation, Enamel Breakdown, Colour of Defect
- Trial name
- MIH (NCT07727200)
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Basel
Congenital Heart Disease, Viremia
Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes
Beyond EV-B, there are clinical observations to implicate other viruses in birth defects, including CHD. Since the Rubella epidemic of 1960s', however, viruses have received little attention and certainly no comprehensive study…
- Conditions
- Congenital Heart Disease, Viremia, Virus Diseases, Enterovirus
- Trial name
- CHARMED (NCT04769167)
- Testing
- Stool and Blood Specimen Collection, Follow-up Medical Record Review
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Neural Tube Defects, Contraception
Efficacy and Safety Study for an Oral Contraceptive Containing Folate
The purpose of this study is to determine whether the study drug is safe and effective
- Conditions
- Neural Tube Defects, Contraception, Oral Contraceptives (OC)
- Trial name
- NCT00468481
- Testing
- Drospirenone/Ethinylestradiol/Methyltetrahydrofolate, Drospirenone/Ethinylestradiol (Yaz)
- Where
- 9 sites in United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Bayer