Clinical trials: Defects
D-Transposition of Great Arteries, Tetralogy of Fallot
Myocardial Contrast Echocardiography in Congenital Heart Disease
Patients with congenital heart disease in whom the right ventricle is exposed to pressure or volume overload show progressive systolic dysfunction of the right ventricle, the fact of which conveys substantial morbidity and…
- Trial name
- NCT00412685
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
22q.11.2 Deletion/Duplication
Non-Invasive Chromosomal Evaluation of 22q11.2
This study is being conducted to develop and evaluate a cell-free fetal DNA test (Harmony) for non-invasive prenatal detection of 22q11.2 chromosomal deletion or duplication.
- Trial name
- 22Q (NCT02541058)
- Where
- Belgium
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Cindy Cisneros
Molar Incisor Hypomineralization
Hypersensitivity After Composite Restoration Versus Preformed Metal Crowns in MIH Molars
The aim of this study is to assess the hypersensitivity after direct composite restorations (DCRs) versus preformed metal crowns (PMCs) in molars affected with molar-incisor hypomineralization (MIH).
- Trial name
- NCT04654858
- Testing
- Direct composite restorations, Preformed metal crowns (PMCs)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Polynesian Bronchiectasis
Bronchi Dilation in Polynesian Patients: Monocentric Retrospective Study
The study hypothesis is that dilations of idiopathic bronchi are particularly common in French Polynesia, and that there are arguments in favour of an underlying genetic factor.
- Trial name
- NCT04798950
- Where
- French Polynesia
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Patent Ductus Arteriosus
Long Term Results of 450 Percutaneous Closures of PDA in a Single Center
Percutaneous closure is one of the methods used to treat, among other congenital heart disorder, Persistent Ductus Arteriosus (PDA) in children and adults.
- Trial name
- NCT01929733
- Where
- Israel
- Volunteers
- 450 people
- Sponsor
- Rambam Health Care Campus
Marfan Syndrome
The Oxford Marfan Trial
The primary objective of the trial is to estimate the effects of allocation to irbesartan, or doxycycline, or a combination of both irbesartan and doxycycline, compared with placebo, on measures of elastic function of the aorta…
- Trial name
- NCT01949233
- Testing
- Irbesartan 150-300mg capsules daily for 6 months, Doxycycline 100-200mg capsules daily for 6 months
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Oxford
Weaning Mechanical Ventilation, Pediatric Cardiac Surgery
Weaning From Mechanical Ventilation After Pediatric Cardiac Surgery
Weaning from mechanical ventilation post congenital cardiac surgery is often challenging. It is well known that not all patients can be early extubated, although most are suitable for early postoperative weaning and extubating…
- Trial name
- NCT07066748
- Testing
- group P:pressure support ventilation mode, group A:automatic tube compensation (ATC).
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Alexandria University
Pyloric Stenosis;Acquired, Congenital Heart Disease
Effects of Prostaglandin E1 Treatment on Pyloric Wall in Newborns
Prostaglandin E1 (PGE1) has been used in the medical treatment of ductal dependent critical congenital heart disease in neonates.
- Trial name
- EOPTOPWT (NCT04496050)
- Testing
- Prostaglandin E1
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Disorders and Postoperative Delirium in Children Undergoing Congenital Heart Surgery
The investigators are going to conduct a prospective observational cohort study in pediatric patients aged 28 days to 14 years old scheduled for elective cardiac surgery with cardiopulmonary bypass.
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06686550
- Testing
- This is a observational study and there is no intervention.
- Volunteers
- 435 people
- Sponsor
- Yan Fuxia
Meningomyelocele, Spinal Dysraphism
Management of Myelomeningocele Study (MOMS)
Spina bifida (myelomeningocele) is a complex birth defect in which a portion of the spinal cord is not fully developed. The overlying bones and skin are incompletely formed and the underdeveloped area of the spinal cord is…
- Trial name
- MOMS (NCT00060606)
- Testing
- Prenatal Myelomeningocele Repair Surgery, Postnatal Myelomeningocele Repair Surgery
- Where
- 3 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Periodontal Disease
EMD and/or Bone Substitute for the Treatment of Class II Furcations
To clinically evaluate the treatment of mandibular class II furcation defects with enamel matrix derivative (EMD) and/or a bone substitute graft make of beta tricalcium phosphate/hydroxyapatite (βTCP/HA).
- Trial name
- NCT02474498
- Testing
- EMD, βTCP/HA, Flap access surgery
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Campinas, Brazil
Persistent Corneal Epithelial Defect
A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED
This study is to evaluate the safety and efficacy of NEXAGON® (lufepirsen ophthalmic gel) (NEXAGON) in subjects with persistent corneal epithelial defects (PCED).
- Trial name
- NEXPEDE-1 (NCT05966493)
- Testing
- lufepirsen high dose, Vehicle, lufepirsen low dose
- Where
- 28 sites in United States, Germany and 2 more
- Volunteers
- 84 people
- Sponsor
- Glaukos Corporation
Bone Defects, Dental Area
RETROSPECTIVE COLLECTION OF SAFETY AND PERFORMANCE DATA - 2023.02
This study, based on observations of clinical practice, aims to collect clinical data to update information on the performance and safety of the n-IBS® when used according to its intended purpose and current clinical…
- Trial name
- NCT07084506
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Bioceramed
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Observational Prospective Study on Patients Treated With Norditropin®
This observational study is conducted globally. The aim of the study is to investigate the effectiveness and safety of real-life treatment with Norditropin®.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Adult Growth Hormone Deficiency, Genetic Disorder
- Trial name
- NCT00960128
- Testing
- somatropin
- Where
- 23 sites in Argentina, Belgium and 21 more
- Volunteers
- 21,249 people
- Sponsor
- Novo Nordisk A/S
Bone Defects
Retrospective Collection of Safety and Performance Data
This is a retrospective post market clinical follow-up study to compile real world clinical data on safety and efficacy of the synthetic bone graft substitutes in a commercial clinical setting in long bone and extremity defects…
- Trial name
- NCT04644536
- Testing
- Bone graft substitute
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Bioceramed
Facial Injuries, Traumatic Wounds and Injuries
Human Craniomaxillofacial Allotransplantation
Background: The human face is critically important for breathing, eating, seeing, and speaking/ communicating, but its most important job may be to look like a human face.
- Conditions
- Facial Injuries, Traumatic Wounds and Injuries, Craniofacial Injuries, Craniofacial Defects
- Trial name
- NCT01889381
- Testing
- Bone marrow cell-based therapy & 1-drug immunosuppression.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Articular Cartilage Defects in the Knee Joint
Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects
Multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (GelrinC). This study compares the efficacy and safety of GelrinC to a historical control arm (microfracture) in the treatment…
- Trial name
- SAGE (NCT03262909)
- Testing
- GelrinC, Microfracture historical control arm
- Where
- 13 sites in United States
- Volunteers
- 181 people
- Sponsor
- Regentis Biomaterials
Post Traumatic Soft Tissue Defects That Could be Reached by Pedicled Anterolateral Thigh Flap, Post Tumor Excision Soft Tissue Defects
Reliability and Versatility of Pedicled Anterolateral Thigh Flap in Reconstruction of Soft Tissue Defects
a prospective case series study for evaluation of the reliability and versatility of pedicled anterolateral thigh flap in the reconstruction of soft tissue defects as regards flap survival and complications, donor site morbidity…
- Conditions
- Post Traumatic Soft Tissue Defects That Could be Reached by Pedicled Anterolateral Thigh Flap, Post Tumor Excision Soft Tissue Defects, Post Debridement Soft Tissue Defects
- Trial name
- NCT06841419
- Testing
- surgical reconstruction of a soft tissue defects by a pedicled flap
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Heart Defects, Congenital, Pediatrics
CHAMP App Cardiac Study and Repository
This is a multi-site research study with an optional research repository that will consist of clinically derived data and photographic or video images of patients in the home setting with complex health conditions to evaluate the…
- Trial name
- CHAMP (NCT06034392)
- Testing
- CHAMP App
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Lori Erickson
Ear Deformity External
Adaptation of Conventional Versus Virtually Fabricated Ear Prosthesis in Patients With Auricular Defects
: patients were recruited for auricular prosthetic reconstruction. Preoperative data was collected including personal and medical history, plain photographs and CT scans.
- Trial name
- NCT05708339
- Testing
- virtually fabricated ear prosthesis, conventionally fabricated ear prosthesis
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fatima Elmougi
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