Clinical trials: Defibrillators, Implantable, open to volunteers
Ventricular Tachycardia, Monomorphic, Ventricular Tachycardia, Sustained
Stereotactic Radiosurgery as Second-line Therapy for Ventricular Tachycardia
The aim of the study is to compare the efficacy and safety of treating recurrent sustained Ventricular Tachycardia (sVT) after prior Catheter Ablation (CA) in patients with Implanted Cardioverter-Defibrillator (ICD) between re-do…
- Conditions
- Ventricular Tachycardia, Monomorphic, Ventricular Tachycardia, Sustained, Ventricular Tachycardia (VT), Ventricular Tachycardia (V-Tach)
- Trial name
- STAR-4VT (NCT07017855)
- Testing
- Stereotactic Arrhythmia Radioablation (STAR), Catheter Ablation
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Silesia
Sudden Cardiac Death, Myocardial Infarction
Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation
Patients who have survived a myocardial infarction (MI) are at increased risk for sudden cardiac death (SCD) caused by ventricular tachycardia and ventricular fibrillation.
- Trial name
- PROFID EHRA (NCT05665608)
- Testing
- Implantable cardioverter-defibrillator (ICD), Optimal Medical Therapy (OMT)
- Where
- 86 sites in Austria, Belgium and 11 more
- Volunteers
- 3,595 people
- Sponsor
- Charite University, Berlin, Germany
Heart Disease, Implantable Cardioverter Defibrillator (ICD)
Optimal Settings for Anti Tachycardia Pacing (ATP) on ICD
This is a pragmatic, two-group, cluster randomized trial designed to compare strategies for the Anti Tachycardia Pacing (ATP)-setting in the ventricular tachyarrhythmias (VT) zone when implanting a new implantable cardioverter…
- Conditions
- Heart Disease, Implantable Cardioverter Defibrillator (ICD), Heart Rhythm Disorders, Ventricular Tachyarrhythmias
- Trial name
- DAN-ATP (NCT07354347)
- Testing
- Burst, Ramp
- Where
- Denmark
- Volunteers
- 3,980 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure, Atrial Fibrillation (AF)
Bachmann Bundle Pacing for Prevention of New-Onset Atrial Fibrillation in Patients With Heart Failure
This is a multi-center, prospective, single-blind, randomized controlled clinical trial to evaluate the efficacy and safety of Bachmann bundle pacing (BBP) in preventing new-onset atrial fibrillation (AF) in patients with chronic…
- Conditions
- Heart Failure, Atrial Fibrillation (AF), Cardiac Insufficiency
- Trial name
- NCT07547449
- Testing
- Bachmann Bundle Pacing, Right Atrial Appendage Pacing
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Myocarditis, Ventricular Arrhythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOPED (NCT06591260)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Heart Failure, Congestive, Death, Sudden, Cardiac
Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention
The overall hypothesis of this study is that subtle interactions between structural (substrate) and functional (trigger) abnormalities of the heart, some of which are genetically-determined, can be used to identify patients at…
- Conditions
- Heart Failure, Congestive, Death, Sudden, Cardiac, Arrhythmia, Cardiomyopathies
- Trial name
- PROSe-ICD (NCT00733590)
- Where
- 4 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Johns Hopkins University
Arrhythmia, Bradycardia
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival…
- Conditions
- Arrhythmia, Bradycardia, Heart Failure, Sinus Tachycardia
- Trial name
- PPR (NCT00271180)
- Testing
- Device
- Where
- 338 sites in United States, Australia and 33 more
- Volunteers
- 20,000 people
- Sponsor
- Medtronic
Arrhythmogenic Cardiomyopathy (AC, ARVD/C), Ventricular Tachycardia (VT)
Treatment Registry of Arrhythmias, Complications and Electrocardiograms in Arrhythmogenic CardioMyopathies
TRACE-ACM is a multicenter, retrospective, observational study of patients with arrhythmogenic cardiomyopathy who received an implantable cardioverter-defibrillator (ICD) and had documented ventricular tachyarrhythmias.
- Conditions
- Arrhythmogenic Cardiomyopathy (AC, ARVD/C), Ventricular Tachycardia (VT), Ventricular Fibrillation, ICD
- Trial name
- TRACE-ACM (NCT07688200)
- Volunteers
- 300 people
- Sponsor
- Policlinico Casilino ASL RMB
Lead Extraction Procedures
Pacemaker and Defibrillator Lead Extraction Registry
Implanted cardiac devices are commonly used to treat a wide variety of heart diseases, including arrhythmias, cardiac resynchronization in select heart failure patients, and life threatening heart rhythms.
- Trial name
- NCT03847025
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Ventricular Tachycardias, Myocardial Infarction (MI)
Endo-ePIcardial Versus Endocardial Only Catheter Ablation for ISchemic Driven Ventricular Tachycardia (EPISODE VT)
The EPISODE VT trial is designed to compare efficacy and safety of two modalities for interventional treatment - endocardial ablation and endo-epicardial ablation in a population of patients with post myocardial infarction (ICD…
- Conditions
- Ventricular Tachycardias, Myocardial Infarction (MI), Implantable Cardiac Defibrillator, Ablation
- Trial name
- EPISODE_VT (NCT07240441)
- Testing
- Endocardial VT ablation, Endo-epicardial VT ablation
- Where
- 9 sites in Poland
- Volunteers
- 220 people
- Sponsor
- MEDICOVER SP Z O.O.
Ischemic Heart Disease, Ventricular Tachycardia
International Multicenter Project Comparing Radiofrequency Ablation Versus Implantable Defibrillator After Well-tolerated Ventricular Tachycardia in Ischemic Heart Disease With Minimally Impaired Ejection Fraction
Evidence for the usefulness of the defibrillator in cases of preserved left ventricular ejection fraction and well-tolerated ventricular tachycardia (without cardiocirculatory arrest or syncope) is lacking, as no previous trials…
- Trial name
- VIVA (NCT06294028)
- Testing
- Adverse events collection, Quality of life questionnaire EQ-5D-5L, Medical-economic evaluation
- Where
- France
- Volunteers
- 268 people
- Sponsor
- University Hospital, Toulouse
Postoperative Care After Cardiac Implantable Electronic Device Implantation
Effects of Short-Term Arm Sling Use After Cardiac Implantable Electronic Device Placement
This randomized controlled trial will evaluate the effects of short-term medical arm sling use during the first 24 hours after cardiac implantable electronic device (CIED) implantation on patient comfort, pain, satisfaction, and…
- Trial name
- CIED-SLING24 (NCT07810426)
- Testing
- Medical Arm Sling
- Volunteers
- 104 people
- Sponsor
- Tugba Yorulmaz
Heart Failure, Atrial Fibrillation
Conduction System Pacing and AV Junction Ablation in Heart Failure With Atrial Fibrillation (SYNC AF-HTx)
The purpose of this study is to evaluate the safety and efficacy of conduction system pacing (CSP) using left bundle branch pacing (LBBP) and atrioventricular junction (AVJ) ablation in patients with end-stage heart failure and…
- Conditions
- Heart Failure, Atrial Fibrillation, Defibrillators, Implantable
- Trial name
- NCT07332871
- Testing
- LBBP + AVJ Ablation with ICD, ICD Only
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Cardiovascular Diseases, Arrhythmias, Cardiac
Multicenter Evaluation of Patients Using LATITUDE Monitoring System
The Multitude is a registry of patients who receive commercially available CIEDs that remotely communicate through the LATITUDE monitoring system and transfer data to a central database.
- Conditions
- Cardiovascular Diseases, Arrhythmias, Cardiac, Heart Failure, Sudden Cardiac Death
- Trial name
- Multitude (NCT06311149)
- Where
- 3 sites in Italy
- Volunteers
- 20,000 people
- Sponsor
- University Hospital of Ferrara
Heart Failure, Nonischemic Cardiomyopathy
Implantable Cardioverter Defibrillator (ICD Registry)
The ICD Registry™ is a nationwide quality program that helps participating hospitals measure and improve care for patients receiving implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy devices…
- Conditions
- Heart Failure, Nonischemic Cardiomyopathy, Ischemic Cardiomyopathy, Ventricular Arrhythmia
- Trial name
- NCT01999140
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- American College of Cardiology
Cardiac Pacing
Cardiac Anodal Biphasic Pacing
The goal of this study is to test a new pacing method called anodal biphasic pacing (ABP) to determine if this pacing works as well-or better-than current pacing methods.
- Trial name
- ABP (NCT07173777)
- Testing
- Cardiac Waveform Generator
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Boston Medical Center
Ventricular Tachycardia (VT)
Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies
The aim of this study is to define the importance of non-invasive programmed stimulation (NIPS) in risk stratification of ventricular tachycardia (VT) recurrence after catheter ablation and to determine the optimal treatment…
- Trial name
- NCT06669299
- Testing
- Re-Do ventricular tachycardia ablation, Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- IRCCS Ospedale San Raffaele
Pacemaker, Implantable Defibrillator
Remote Alert Pathway To Optimize CaRe of Cardiac Implantable Electrical Devices: The RAPTOR-CIED Study (Main Phase)
he Remote Alert Pathway to Optimize Care of Cardiac Implantable Electrical Devices (RAPTOR-CIED) Study is a pragmatic, multi-center, randomized trial with 1:1 patient-level randomization comparing the safety and effectiveness of…
- Trial name
- RAPTOR - MAIN (NCT07352657)
- Testing
- Alert-based care, Guideline-based Care
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Beth Israel Deaconess Medical Center
Ventricular Tachycardia, Implantable Defibrillator User
END - VT Cohort Study
Ventricular tachycardia (VT) is a life-threatening cardiac rhythm disturbance which leads to sudden cardiac death (SCD), ventricular fibrillation, electrical storm, hemodynamic collapse, and syncope.
- Conditions
- Ventricular Tachycardia, Implantable Defibrillator User, ICD
- Trial name
- END VT (NCT05835791)
- Where
- 3 sites in Canada
- Volunteers
- 2,454 people
- Sponsor
- Nova Scotia Health Authority
Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Left Ventricular Structural Predictors of Sudden Cardiac Death
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function.
- Trial name
- NCT01076660
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University