Clinical trials: Degenerative Joint Disease
Hip Osteoarthritis
Platelet-Rich Plasma and Hip Osteoarthritis
To evaluate the effect of platelet-rich plasma (PRP) injection on pain, function and quality of life in patients with hip osteoarthritis.
- Trial name
- NCT04820231
- Testing
- intra-articular PRP injection
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Osteoarthritis of Hip
A Study of Posterior Hip Precautions After Total Hip Arthroplasty
The purpose of this study is to perform a randomized controlled study to compare patients undergoing THA via a posterolateral approach to receive either standard of care post-surgery hip restrictions or to receive no…
- Trial name
- HIPPRECAU (NCT03341442)
- Testing
- No hip precautions
- Where
- United States
- Volunteers
- 321 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Osteoarthritis, Post-traumatic Arthritis
Foundation Knee Study - Retrospective
The purpose of this study is to evaluate the use and efficacy of the Encore Foundation Knee System in a group of 200 patients for whom data has already been collected.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Inflammatory Tissue Disorders, Arthritis Secondary to Other Diseases
- Trial name
- NCT00764894
- Testing
- Foundation Knee
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Encore Medical, L.P.
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Cold and Compression Post TKA
The purpose of this study is to compare pain score (Patient-Reported Outcomes Measurement Information System: PROMIS NRS Pain Subscale) between the control and cold/compression groups pre-surgically, daily after surgery for 14…
- Trial name
- NCT07023185
- Testing
- Cold and Compression, SOC (Standard of care)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ochsner Health System
Osteoarthritis, Osteo Arthritis Knee
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints
- Trial name
- GARM-MSK-ALD (NCT04238143)
- Testing
- Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Osteoarthritis, Hip Dislocation
Supine Sleeping After Total Hip Replacement
Aim of the current study is to test the non-inferiority hypothesis of differences in early hip dislocation between a group of patients who will be restricted to sleep in supine position and a group without restricted sleeping…
- Trial name
- NCT02107248
- Testing
- Sleep position: no restrictions, Sleep position: supine
- Where
- Netherlands
- Volunteers
- 456 people
- Sponsor
- Orthopedisch Centrum Oost Nederland
Knee Osteoarthritis
Exercise and Pain Sensitivity in Knee Osteoarthritis
A commonly administered conservative non-pharmacological treatment for OA is exercise, with beneficial effects in terms of reduced pain and disability. While the link between exercise and reduced disability is mediated by e.g.
- Trial name
- NCT01545258
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Frederiksberg University Hospital
Degenerative Joint Disease
Comparison of A Mobile-Bearing Total Knee System With A Fixed-Bearing Total Knee System In Cemented Total Knee Arthroplasty
Pain, weakness, instability, and progressive dysfunction are the hallmarks of arthritis of the knee. Total knee replacement may frequently be the only therapeutic intervention to provide adequate improvement in pain and function.
- Trial name
- NCT00589108
- Testing
- Sigma Knee System, Sigma Pressfit Condylar Posterior Cruciate Substituting System with a metal back tibial tray, Sigma Pressfit Condylar Posterior Cruciate Substituting System all polyethylene tray
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Mayo Clinic
Osteoarthritis of Knee
Total Knee Replacement Component Alignment Using Manual Versus Custom Instrumentation
1. To determine whether the low-dose, biplanar x-ray imaging (EOS) has the same accuracy as computed axial tomography (CT) 2. To validate low-dose, biplanar x-ray imaging (EOS) as a tool to evaluate 3-dimensional alignment of…
- Trial name
- NCT02579174
- Testing
- Medacta GMK Sphere
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Northwestern University
Knee Osteoarthritis
Exercise and Physical Fitness for Persons With Knee Osteoarthritis
The purpose of this project is to establish evidence to support specific, targeted exercise and rehabilitation recommendations for people over 50 with osteoarthritis of the knee.
- Trial name
- NCT00265447
- Testing
- Strength training, Aerobic conditioning, Delayed exercise
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Osteoarthritis, Peripheral
Innovative Device for Pain Management by Millimeter Band Radiation : Electronic-Pain Killer.
In this study, in addition of conventional treatment, the efficacy of the medical device, Remedee One, in medical care of patients with peripheral osteoarthritis pain is evaluated.
- Conditions
- Osteoarthritis, Peripheral, Pain
- Trial name
- Epikarthrose (NCT04590079)
- Testing
- Conventional pain treatment with daily sessions with innovative medical device, Remedee One, for pain management by Millimeter Band Radiation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- EVALMOB (NCT04375280)
- Testing
- Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Kinematics in Posterior Cruciate Retaining and Bi-Cruciate Retaining Total Knee Replacements
The purpose of the study is to acquire kinematic in vivo fluoroscopy data from subjects who were implanted with the Smith \& Nephew Journey II posterior cruciate retaining (PCR) total knee arthroplasty (TKA) or Journey II…
- Trial name
- NCT03088748
- Testing
- Journey II posterior cruciate retaining total knee arthroplasty, Journey II posterior bi-cruciate retaining total knee arthroplasty
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis
Safety and Biologic Activity Study of Gevokizumab to Treat Erosive Osteoarthritis of the Hand
The purpose of this proof-of-concept study is to determine whether gevokizumab is effective in the treatment of inflammatory erosive osteoarthritis of the hand.
- Trial name
- NCT01882491
- Testing
- gevokizumab
- Where
- 23 sites in United States
- Volunteers
- 91 people
- Sponsor
- XOMA (US) LLC
Cervical Osteoarthritis
Pulse Shortwave Therapy in Cervical Osteoarthritis
The ActiPatch is an FDA cleared pain therapy device that uses pulsed shortwaves to interrupt pain signals at the nerve. 200 patients will be randomized and divided into an ActiPatch treatment group and comparison analgesic drug…
- Trial name
- NCT03542955
- Testing
- ActiPatch, Etoricoxib 60 mg
- Where
- Lebanon
- Volunteers
- 180 people
- Sponsor
- BioElectronics Corporation
Osteoarthritis, Arthritis
Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study
This is an efficacy and safety study of 3 doses (2.5 mg, 5 mg and 10mg) of tanezumab administered subcutaneously versus placebo.
- Conditions
- Osteoarthritis, Arthritis, Pain
- Trial name
- NCT01089725
- Testing
- Tanezumab SC, Tanezumab IV
- Where
- 91 sites in United States
- Volunteers
- 385 people
- Sponsor
- Pfizer
Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos
Observational Study Evaluating Outcomes of Hip Arthroplasty Using Tornier Dual Mobility Acetabular Cup
The purpose of this study is to demonstrate the performance and reliability of Tornier "Dual Mobility Cup" used during primary total hip replacement or hip replacement revision surgery at least 24 months post-insertion.
- Conditions
- Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos, Femur Head Necrosis, Femur Neck Fracture
- Trial name
- NCT02062450
- Testing
- Primary surgery with Dual Mobility Cup, Revision surgery with Dual Mobility Cup
- Volunteers
- 379 people
- Sponsor
- Stryker Trauma and Extremities
Cartilage Diseases, Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for articular cartilage defect of knee.
- Trial name
- NCT02291926
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Cardiovascular Disease Risk, Rheumatoid Arthritis (RA)
Cardiovascular Disease Awareness in Rheumatoid Arthritis and Knee Osteoarthritis
Cardiovascular diseases (CVD) are still the most common cause of death. For these reasons, individuals, especially those with chronic diseases, need to be aware of CVD.
- Conditions
- Cardiovascular Disease Risk, Rheumatoid Arthritis (RA), Knee Osteoarthritis
- Trial name
- NCT07056608
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Osteoarthritis (OA) of the Knee
Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty
Participants are being invited to take part in a research study about pain control after total knee replacement surgery (also called total knee arthroplasty or TKA).
- Trial name
- NCT07775248
- Testing
- Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
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