Clinical trials: Degenerative Lumbar Diseases
Intervertebral Disk Degeneration
Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction
This is a parallel, randomized controlled trial comparing two types of patient positioning and their effect on radiologic measures (pre-surgery visit, in the operating room prior to surgery, at the conclusion of surgery, and at 3…
- Trial name
- NCT01326091
- Testing
- Hyperlordotic Positioning
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Degenerative Disc Disease
A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
The objectives of the study are to evaluate the safety and preliminary efficacy of a single administration of AGA111 for lumbar interbody fusion in patients with degenerative disc disease.
- Trial name
- NCT05574543
- Testing
- AGA111
- Where
- 6 sites in China
- Volunteers
- 60 people
- Sponsor
- Angitia Biopharmaceuticals
Degenerative Disc Disease
Intradiscal rhGDF-5 Phase I/II Clinical Trial
Study to show the effectiveness and safety of a single injection of rhGDF5 into a degenerating single spinal disc in treating lumbar level degenerative disc disease
- Trial name
- NCT00813813
- Testing
- Intradiscal rhGDF-5
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- DePuy Spine
Degenerative Disc Disease, Intervertebral Disc Disease
Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)
In this study we want to evaluate the clinical use of allogenic mesenchymal stem cells (MSC), obtained from bone marrow of healthy donors, for treatment of Degenerative Disc Disease (DDD).
- Conditions
- Degenerative Disc Disease, Intervertebral Disc Disease, Low Back Pain
- Trial name
- Disc_allo (NCT01860417)
- Testing
- Allogenic Mesenchymal Stromal Cells, Mepivacaine
- Where
- 2 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Red de Terapia Celular
Degenerative Conditions of the Lumbar Spine, Lumbar Spinal Stenosis
Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device
This is a prospective, multi-center open-label single arm post-market study where the purpose is to evaluate the effectiveness and safety of the market approved Spinal Simplicity Minuteman G5 MIS Fusion Plate and bone graft…
- Conditions
- Degenerative Conditions of the Lumbar Spine, Lumbar Spinal Stenosis, Spondylolisthesis
- Trial name
- STABILITY (NCT06355791)
- Testing
- Minuteman G5 Device
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- Spinal Simplicity LLC
Postoperative Pain Control, Lumbar Spine Surgery
Intertransverse Process Block Versus Erector Spinae Plane Block for Pain Relief in Lumbar Spine Surgery
The goal of this clinical trial is to learn whether two types of ultrasound-guided nerve block, the intertransverse process block and the erector spinae plane block, reduce pain and the need for opioid pain medicines during and…
- Conditions
- Postoperative Pain Control, Lumbar Spine Surgery, Degenerative Lumbar Spine Diseases
- Trial name
- NCT07878013
- Testing
- Erector Spinae Plane Block, Intertransverse Process Block, Local anesthetic infiltration
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- Hanoi Medical University
Osteoporosis, Degenerative Lumbar Disease
Osteo Match Cages Versus PEEK Cages in Osteoporotic Patients
This is a multicenter, prospective cohort study. The osteoporotic patients requiring posterior lumbar interbody fusion(LIF) with cages are prospectively enrolled and followed up.
- Conditions
- Osteoporosis, Degenerative Lumbar Disease, Degeneration Spine
- Trial name
- OMC (NCT05981222)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking University Third Hospital
Degenerative Disc Disease
Study to Assess the Performance of MagnEtOs Flex Matrix Compared to Cellular Allograft
The purpose of this study is to demonstrate the performance of MagnetOs Flex Matrix in patients with leg pain and/or back pain.
- Trial name
- NCT06415123
- Testing
- MagnetOs Flex Matrix
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Research Source
Lumbar Spine Disc Degeneration
Study to Evaluate Safety and Effectiveness of Dynamic Stabilization Versus Lumbar Fusion in Treatment of Multilevel Lumbar Disc Degeneration Disease
The purpose of this study is to compare outcomes of (i) surgical treatment with posterior dynamic stabilization and (ii) surgical treatment with internal fixation and fusion in patients with multilevel lumbar degenerative disk…
- Trial name
- MLIDH (NCT02385695)
- Testing
- Posterior Dynamic Stabilization, Internal Fixation and Fusion
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Qiang Zhou, MD. PhD.
Lumbar Disc Degenerative Disease
Drug Use Survey (DUS) of Triple Therapy (Methycobal (MBL)+ Myonal (MYO)+ Non-steroidal Anti-inflammatory Drags (NSAID)) on the Symptom Relief of Lumbar DDD in China
The purpose of this study is to observe the overall satisfaction of patients with degenerative disc disease after receiving triple therapy.
- Trial name
- NCT01299077
- Where
- 10 sites in China
- Volunteers
- 478 people
- Sponsor
- Eisai China Inc.
Degenerative Changes, Stenosis
Accell Evo3™ Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra Accell Evo3 Demineralized Bone Matrix as an adjunct for instrumented posterolateral spine fusion, as compared to local autograft.
- Conditions
- Degenerative Changes, Stenosis, Spondylosis
- Trial name
- NCT02018445
- Testing
- Posterolateral Fusion
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- SeaSpine, Inc.
Lumbar Disc Herniation, Degenerative Disc Disease
Peri-Incisional Drug Injection in Lumbar Spine Surgery
This is a randomized prospective study that will compare the use of narcotics in a control group of non-injected patients with a treatment arm of patients injected intra-operatively with a ropivacaine, morphine, and epinephrine…
- Conditions
- Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
- Trial name
- NCT03513445
- Testing
- Morphine, Epinephrine, naropin
- Where
- United States
- Sponsor
- University of Minnesota
Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis
Efficacy of Using Solum IV and BMC With GFC in TLIF
The purpose of this study is to examine the efficacy of using Solum IV and bone marrow concentrate with general fluid concentrate in Transforaminal Lumbar Interbody Fusion (TLIF).
- Conditions
- Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT03223701
- Testing
- Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seton Healthcare Family
Osteoporosis, Degenerative Disc Disease
3D-printed Porous Titanium Alloy Cages Versus PEEK Cages in Patients With Osteoporosis
This is a prospective,observational single-center study. The osteoporotic patients requiring posterior lumbar interbody fusion(PLIF) with cages at the lowest fusion segment are prospectively enrolled and followed up.
- Conditions
- Osteoporosis, Degenerative Disc Disease, Degenerative Lumbar Spinal Stenosis, Degeneration Spine
- Trial name
- 3DCOP (NCT04086784)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking University Third Hospital
Degenerative Disc Disease
Study of the ReGelTec HYDRAFIL System
A study designed to treat patients with back pain associated with degenerative lumbar disc disease.
- Trial name
- NCT04984629
- Testing
- HYDRAFIL
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- ReGelTec, Inc.
Spondylodiscitis
Cytokine Profiles and suPAR in Spondylodiscitis
Spondylodiscitis is an infectious disease of the intervertebral discs and adjacent vertebral bodies, which often has a protracted progression.
- Trial name
- NCT02554227
- Testing
- Cytokine Profile and suPAR
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Cologne
Low Back Pain
Clinical, Morphological and Functional Success Predictors Following Lumbar Spinal Surgery in Patients With Chronic Low Back Pain and Degenerative Disorders.
The long term goal of this project is dual fold. First, the investigators wish to derive, validate and then test the impact of a clinical prediction rule to determine which patients who suffer from CLBP with degenerative changes…
- Trial name
- NCT02444702
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Lumbar Disc Disease
Intra-operatory Neurophysiological Monitoring Changes as a Predictive Clinical Outcome Measure in Lumbar Radiculopathy.
The purpose of this study is to determine the relation among: (1) changes in voltage and amplitude of trans-operatory records obtained through the use of Intra-operative Neurophysiological Monitoring (IONM), and (2) clinical…
- Trial name
- NCT02185508
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- American British Cowdray Medical Center
Lumbar Degenerative Disc Disease
TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study
The purpose of this investigation is to evaluate the safety and effectiveness of the TRIUMPH® Lumbar Artificial Disc for the treatment of patients who are suffering from Degenerative Disc Disease (DDD) at one level from L1 to S1.
- Trial name
- NCT01198470
- Testing
- TRIUMPH® Lumbar Artificial Disc
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Globus Medical Inc
Degenerative Disc Disease
Outcomes of Degenerative Disc Disease Patients Treated With an Anterior-Only Fusion Using InQu Bone Graft
The purpose of this study is to report the radiographic, clinical, and functional outcomes of a consecutive series of patients diagnosed with single or bilateral degenerative disc disease between L4 and S1, that have been treated…
- Trial name
- InQu (NCT01746212)
- Testing
- One-level or two-level anterior lumbar interbody fusion, InQu Bone Graft Extender and Substitute mixed with BMAC, Synthes Spinal Instrumentation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kansas Joint and Spine Institute