Clinical trials: Degenerative Osteoarthritis
Osteoarthritis
Aerobic Exercise Intervention for Knee Osteoarthritis
This trial will test if walking or bicycling exercise is effective as a non-surgical treatment option for patients with knee osteoarthritis.
- Trial name
- NCT00049816
- Testing
- Walking exercise, Cycling Exercise
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Total Knee Replacement
Knee Arthroplasty Activity Trial
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA).
- Trial name
- KArAT (NCT04107649)
- Testing
- Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives, Wrist based activity tracker wear, Basic Study Activities
- Where
- 5 sites in United States
- Volunteers
- 600 people
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis
The Knee Usual Care Evaluation Study
The purpose of this prospective data collection is to track patients who are treated at HSS who are confirmed with knee osteoarthritis.
- Trial name
- KUCE (NCT01905358)
- Where
- United States
- Volunteers
- 906 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis
The Efficacy and Safety of Intraarticular Sodium Hyaluronate (Hyalgan) After Proximal Tibial Osteotomy in Treatment of Knee Osteoarthritis Patients
The purpose of this study is to assess the efficacy and safety of Hyalgan after proximal tibial osteotomy in treatment of knee osteoarthritis patients.
- Trial name
- NCT01267214
- Testing
- Sodium Hyaluronate (Hyalgan), Osteotomy alone
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- TRB Chemedica
Knee Osteoarthritis
Robot-Assisted Partial Knee Replacement Versus Standard Total Knee Replacement
This is a pilot randomized trial to assess the feasibility of a definitive trial to determine the effect of robot-assisted partial knee replacements versus standard total knee replacements.
- Trial name
- RoboKnees (NCT04378049)
- Testing
- Total knee arthroplasty, Robot-assisted partial knee arthroplasty
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- McMaster University
Osteoarthritis, Chronic Pain
OASIS: Osteoarthritis Sensitivity Integration Study
The primary objective of this study is to evaluate the relative efficacy of a centrally-acting analgesic (duloxetine) versus a peripherally acting analgesic (topical diclofenac) for pain and associated symptom management in knee…
- Trial name
- OASIS (NCT01377038)
- Testing
- Phenotype assessment
- Where
- United States
- Sponsor
- University of Michigan
Knee Osteoarthritis (Knee OA)
High-Intensity Laser Therapy (HILT) in Patients With Knee Osteoarthritis
This randomized placebo-controlled trial aims to evaluate the effectiveness of High-Intensity Laser Therapy (HILT) as an adjunct to standard outpatient physiotherapy in patients with knee osteoarthritis.
- Trial name
- NCT07661407
- Testing
- Conventional Physiotherapy, High-Intensity Laser Therapy (HILT)
- Volunteers
- 72 people
- Sponsor
- University of Rzeszow
Osteoarthritis, Chronic Pain
Mindfulness for Osteoarthritis-related Knee Pain
The purpose of this project is to investigate the feasibility and acceptability of a Mindfulness based intervention for people who are attending secondary care with Osteoarthritis (OA)-related knee pain.
- Trial name
- NCT02595099
- Testing
- Mindfulness training
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Knee Osteoarthritis
Metformin as Adjuvant Therapy in Obese Knee Osteoarthritis Patients
This study aims to evaluate the possible efficacy and safety of addition of metformin to celecoxib in patients with knee osteoarthritis.
- Trial name
- NCT05638893
- Testing
- Metformin Hcl 500Mg Tab
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Osteoarthritis, Knee, Osteoarthritis Knees Both
Astaxanthin for Management of Inflammation in Knee Osteoarthritis
Over 30 million Americans are currently affected by osteoarthritis (OA), with prevalence expected to increase 40% by 2025 as a result of the aging population and obesity epidemic.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
- Trial name
- NCT05138549
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Prisma Health-Midlands
Osteoarthritis, Knee
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis
This is a Pilot Study which is randomized, prospective, open label, dose escalation, non-controlled evaluating safety and feasibility of intra-articular Wharton's Jelly (WJ) allograft will be evaluated in patients suffering with…
- Trial name
- NCT06608134
- Testing
- Umbilical Cord Wharton's Jelly Allograft Intra-articular Knee Injection
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- R3 Medical Research
Osteoarthritis of Knee
Robot-Aided Off-Axis Neuromuscular Training for Knee OA
Although the primary knee motion occurs in flexion/extension, the frontal and transverse (off-axis) knee motions are smaller but crucial for maintaining joint stability and normal knee loading.
- Trial name
- NCT07014098
- Testing
- Robot-Aided Off-Axis Neuromuscular Training, Traditional elliptical regular stepping
- Volunteers
- 36 people
- Sponsor
- University of Maryland, Baltimore
Osteoarthritis of Knee
The Recovery Time of Quadriceps Strength After Total Knee Arthroplasty (TKA): The Effect of Quadriceps Incision Length
Minimally invasive total knee arthroplasty (MIS-TKA) became the popular technique. It had the less postoperative pain and shorter recovery time compared to the conventional technique.
- Trial name
- NCT01450904
- Testing
- Quadriceps incision < 2 cm, Quadriceps incision 2-4 cm, Quadriceps incision > 4 cm
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Knee Osteoarthritis
AposTherapy for Singaporean Patients With Knee Osteoarthritis (OA)
Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. It is estimated that 7% of men and 11% of women over the age of 65 have KOA.
- Trial name
- NCT01562652
- Testing
- AposTherapy (All Phases of Step-cycle {APOS} system, APOS-Medical and Sports Technologies Ltd. Herzliya, Israel)
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Apos Medical and Sports Technology Ltd.
Osteoarthritis
An Investigation of ReNu™ Knee Injection in Patients With Osteoarthritis
This is a Prospective, Randomized study evaluating the efficacy of ReNu for the treatment of Kellgren-Lawrence grade 2 or 3 osteoarthritis.
- Trial name
- NCT02318511
- Testing
- Knee injection, ReNu amniotic allograft, Hyaluronic Acid
- Where
- 12 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NuTech Medical, Inc
Osteoarthritis
Influence of Oxidative Dysbalance on Secondary Osteoarthritis
The important role of mechanical joint stress for the insert and progress of osteoarthritis (OA) is supported by recent studies.
- Trial name
- NCT01228487
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Unilateral Primary Osteoarthritis of Knee
Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty
Osteoarthritis is a progressive disease afflicting to two thirds of Americans. Today, an estimated 43 million individuals have arthritis. By 2020, more than 59.4 million Americans will be affected by the disease.
- Trial name
- NCT01764984
- Testing
- Total knee arthroplasty
- Where
- 3 sites in Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Knee Osteoarthritis
Cemented vs Cementless TKA
The purpose of this study is to compare cemented and cementless versions of the Triathlon total knee arthroplasty/replacement (TKA) in terms of clinical outcomes, perioperative course, and outcome scores including function and…
- Trial name
- NCT03683992
- Testing
- Triathlon total knee system
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Osteoarthritis Shoulder, Rotator Cuff Tears
DenCT Shoulder Bone Quality Evaluation
The objective of the study is to evaluate the preoperative bone quality assessment based on CT to later establish a scale for the decision of stemless shoulder arthroplasty.
- Trial name
- NCT06032416
- Testing
- Preoperative CT Scan
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Synovitis of Knee, Osteoarthritis, Knee
The Role of Synovitis in Osteoarthritis
To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.
- Trial name
- NCT03167333
- Testing
- platelet rich plasma, Hyaluronic acid
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
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