Clinical trials: Deglutition, open to volunteers
Dysphagia, Achalasia, Esophageal
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Swallowing difficulties are extremely common and result in substantial morbidity, reduction in the quality of life, and mortality related to malnutrition and complications from regurgitation and aspiration.
- Conditions
- Dysphagia, Achalasia, Esophageal, Ineffective Esophageal Motility
- Trial name
- NCT06883175
- Testing
- FLIP, HRM, Prucalopride
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- Northwestern University
Deglutition Disorders, Dysphagia
AI-Enabled Mobile App for Safe Eating in Older Adults With Dysphagia
Difficulty swallowing (called dysphagia) is common in older adults and can make eating and drinking unsafe. It may lead to serious problems such as choking, lung infections, poor nutrition, and reduced quality of life.
- Trial name
- NCT07654088
- Testing
- AI-Enabled Mobile Application plus Standard Care, Standard Dysphagia Education
- Where
- Hong Kong
- Volunteers
- 332 people
- Sponsor
- KAM Chi Shan Anna
Dysphagia, Heart Transplant Recipients
Respiratory Strength Training in Heart Transplant Recipients
This research study is investigating whether completing breathing exercises before surgery helps heart transplant patients recover after surgery.
- Trial name
- NCT06190171
- Testing
- Active respiratory muscle strength training
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
Head and Neck Neoplasms, Swallowing Sparing IMRT
The SWOAR Trial Sparing of Swallowing and Aspiration Related Organs at Risk & Submandibular Gland With Intensity Modulated Radiotherapy Versus Standard IMRT in Head and Neck Squamous Cell Carcinomas
The aim of SWOAR TRIAL is to test sparing of Dysphagia/ Aspiration risk structures (DARS) and contra lateral submandibular gland by IMRT.
- Trial name
- SWOAR (NCT05187091)
- Testing
- Swallowing and submandibular sparing IMRT, Standard IMRT with medical CRT/RT, Cisplatine
- Where
- India
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding
Comparison of Sedated and Unsedated PEG in Elderly ASA IV Patients
This prospective observational cohort study aims to compare the safety and clinical outcomes of sedated and unsedated percutaneous endoscopic gastrostomy procedures in elderly patients classified as ASA IV.
- Conditions
- Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding, Dysphagia, Elderly Patients (>65 Years)
- Trial name
- NCT07758153
- Volunteers
- 70 people
- Sponsor
- Mersin University
Dysphagia Following Cerebrovascular Accident
Evaluation of Effectiveness of an Interactive Dysphagia Education System for Patients With Stroke
The goal of this clinical trial is to learn if an interactive dysphagia education system can improve swallowing outcomes and quality of life in patients with post-stroke dysphagia.
- Trial name
- NCT07810374
- Testing
- Interactive dysphagia education
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Mei-Yu Lin
Dysphagia, Dysphagia, Oropharyngeal
K01 Impacts of Lingual Endurance Exercise
The goal of this clinical trial is to learn whether a tongue endurance exercise program can improve swallowing function in adults with dysphagia after a stroke.
- Conditions
- Dysphagia, Dysphagia, Oropharyngeal, Ischemic Stroke, Stroke
- Trial name
- NCT06072924
- Testing
- Isotonic Endurance Exercise
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Cincinnati
Radiation-associated Dysphagia, Head &Amp; Neck Cancer
Novel Treatment of Radiation Associated Dysphagia With Statins
The aim of this trial is to examine the feasibility, acceptability, and potential efficacy of a 12-month course of pravastatin as an antifibrotic agent for managing dysphagia (swallowing problems) in patients previously treated…
- Trial name
- TRADstat (NCT07217938)
- Testing
- Pravastatin 40 Mg Oral Tablet
- Where
- Australia
- Volunteers
- 48 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Dysphagia, Stroke
Digital Intelligent Tongue-Pressure Biofeedback Resistance Training for Post-Stroke Dysphagia: A Randomized Controlled Trial
Post-stroke dysphagia is a common complication of stroke and may lead to impaired oral intake, malnutrition, aspiration, and pneumonia.
- Trial name
- NCT07798401
- Testing
- Digital Intelligent Tongue-Pressure Biofeedback Resistance Training, Conventional Tongue-Pressure Resistance Training
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First People's Hospital of Foshan
Stroke, Swallowing Disorders
Comparison of NMES, tDCS, and TMS Treatments in Post-Stroke Dysphagia
This randomized, single-blind, controlled clinical trial aims to compare the effectiveness of neuromuscular electrical stimulation (NMES) administered alone or in combination with transcranial direct current stimulation (tDCS) or…
- Conditions
- Stroke, Swallowing Disorders, Dysphagia
- Trial name
- NCT07793799
- Testing
- Neuromuscular Electrical Stimulation, Active Transcranial Direct Current Stimulation, Active Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Atlas University
Deglutition Disorders in Infants, Chronic Tube Feeding in Hospitalized Infants
Parent Implemented Oral Nutrition, Eating, and Esophageal Reflexes Reintegration Protocol: RCT
Feeding dysfunction remains a major unmet challenge among neonatal ICU survivors, frequently leading to prolonged tube feeding or gastrostomy at discharge, increased healthcare utilization, substantial socioeconomic burden, and…
- Trial name
- PIONEER (NCT07035912)
- Testing
- PIONEER Protocol
- Volunteers
- 130 people
- Sponsor
- Nationwide Children's Hospital
Deglutition Disorders in Disabled Persons
Interest of Telemedicine in Primary Care in an Multidisability Population Institutionalized
Swallowing disorders are common and fall within the scope of primary care (as basic, essential health services accessible to all individuals within a community).
- Trial name
- TEDDY (NCT07792187)
- Testing
- Experimental procedure: swallowing assessment by telemedicine, Standard procedure: day hospitalization
- Where
- 5 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Toulouse
Dysphagia, Sarcopenia
Masseter and Rectus Femoris Ultrasound for Dysphagia and Sarcopenia in Critically Ill Patients
Dysphagia and sarcopenia are common complications in critically ill patients and are associated with increased morbidity, prolonged hospitalization, nutritional complications, and poorer clinical outcomes.
- Trial name
- NCT07787312
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Sara Casanova Prieto
Oropharynx Cancer, Radiotherapy; Complications
Adaptive RadioTherapy for OroPharynx Cancer
This is a phase II randomized trial, where patients with histologically proven squamous cell carcinoma of oropharynx that have primary tumor (T3 - T4) in place, treated with curative intent chemoradiation, will be randomized to…
- Conditions
- Oropharynx Cancer, Radiotherapy; Complications, Radiotherapy Side Effect, Dysphagia
- Trial name
- ART-OPC (NCT04901234)
- Testing
- Standard radiotherapy +/- chemotherapy, Experimental radiotherapy +/- chemotherapy
- Where
- 2 sites in Australia, Canada
- Volunteers
- 120 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Dysphagia, Esophageal Stricture
Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions
This is a prospective, single-center, crossover study comparing EndoFLIP measurements obtained in two patient positions, supine and left lateral decubitus, in pediatric and young adult patients.
- Conditions
- Dysphagia, Esophageal Stricture, Epidermolysis Bullosa (EB), Achalasia
- Trial name
- NCT07780981
- Testing
- EndoFlip
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Dysphagia
Mechanisms of Air-pulse Pharyngeal Sensory Stimulation Regulation Post-stroke Swallowing Neural Network Remodeling Via TRPV4 Channel
This randomized, double-blind, sham-controlled clinical trial will investigate the effects and potential neural mechanisms of pharyngeal air-pulse sensory stimulation in patients with post-stroke dysphagia.
- Trial name
- NCT07782424
- Testing
- Air-Pulse Sensory Stimulation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Foshan
Dysphagia
AI-Based Dysphagia Rehabilitation Program: Development and Validation
The goal of this clinical study is to learn if an artificial intelligence (AI)-assisted swallowing rehabilitation program can improve swallowing function in adults with dysphagia.
- Trial name
- NCT07767123
- Testing
- Neuromuscular electrical stimulation for swallowing, Multi-sensor swallowing screening for dysphagia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Research Center for Rehabilitation Technical Aids
Dysphagia, Parkinson Disease (PD)
Exploring the Efficacy of the Effortful Swallow Maneuver for Improving Swallowing in People With PD
The goal of this clinical trial is to learn whether a 4-week effortful swallow exercise program helps adults with Parkinson disease who have swallowing problems.
- Trial name
- EFFORT-PD (NCT07773025)
- Testing
- Effortful swallow
- Volunteers
- 74 people
- Sponsor
- University of Alberta
Swallowing Disorders
Modelling of Pharyngeal Laryngeal Effectiveness
The purpose of this study is to collect the signals of pharyngeal laryngeal activity through five non-invasive sensors (microphone, accelerometer, surface electromyography (EMG), nasal cannula and oximeter) in order to identify…
- Trial name
- Eph-L (NCT06014710)
- Testing
- Swallowing evaluation
- Where
- 4 sites in France
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse