Clinical trials: Deglutition Disorder
Dysphagia, Dysphonia
The Effect of IV NSAID's and Corticosteroids on Dysphasia and Dysphonia Following ASDF
This study is to assess the efficacy of intra-operative intravenous non-steroidal anti-inflammatory drug (Ketorolac) versus intravenous (dexamethasone) administration on dysphagia and dysphonia after anterior cervical discectomy…
- Trial name
- NCT04650893
- Testing
- Intravenous Ketorolac, Intravenous Dexamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Stroke, Swallowing Disorders
Description and Modeling of Swallowing Disorders After a Stroke
The oropharyngeal junction participates in 3 interpenetrating functions: Swallowing, Breathing and Speech. In the context of ischemic or hemorrhagic stroke, these are altered, isolated or associated manner, causing major…
- Trial name
- AVC-MODE (NCT02974530)
- Testing
- Neurological evaluation, Laryngological evaluation, MRI evaluation
- Where
- 4 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Gastroesophageal Reflux Disease (GERD)
The EndoGastric Solutions TEMPO Trial
The purpose of this study is to assess the efficacy and safety of Transoral Incisionless Fundoplication (TIF) performed with EsophyX as compared to proton pump inhibitor (PPI) therapy for the treatment of chronic Gastroesophageal…
- Trial name
- TEMPO (NCT01647958)
- Testing
- EsophyX System with SerosaFuse fasteners, PPI
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- EndoGastric Solutions
Eosinophilic Esophagitis
Esophageal Absorption in EoE
To determine how the esophagus in active and inactive stages of eosinophilic esophagitis tranmit fluids.
- Trial name
- EoE (NCT02314455)
- Testing
- D-xylose
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Stroke
The Changes of Masticatory / Swallowing Functions and Oropharyngeal Muscle Mass on Sonography After Comprehensive Swallowing Training and Tongue - Pressure Resistance Training in Stroke Patients With Dysphagia
The aims of this study are: 1. Comparing the ultrasound imaging performance of swallowing and chewing function, tongue pressure and oropharyngeal muscle thickness in stroke patients with different levels of swallowing function 2.
- Trial name
- NCT06269718
- Testing
- swallowing therapy, IOPI therapy
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Gastroesophageal Reflux
Coordination Versus Pressure in Oesophageal Peristalsis
High Resolution Manometry (HRM) is a new advance in oesophageal measurement that permits the acquisition of pressure data through the entire length of the oesophagus over time via closely spaced sensors that continuously record…
- Trial name
- NCT00482885
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Laryngopharyngeal Reflux
Comparison of Voice Therapy and Antireflex Therapy in LPR
This study will be a prospective, randomized, unblinded but controlled trial. Patients presenting to the Otolaryngology clinic who are diagnosed with laryngopharyngeal reflux disorder related dysphonia and meet inclusion criteria…
- Trial name
- NCT02530879
- Testing
- Omeprazole, Lansoprazole, Esomeprazole, Rantidine, Voice therapy, Combination of anti-reflux medication and voice therapy
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Temple University
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Gastroesophageal Reflux
Natural History of Gastroesophageal Reflux (GER) in Children and Adolescents
The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts…
- Trial name
- NCT00181805
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dysphagia, Fecal Incontinence
Evaluation of Potential Vitamin D Effects on Muscle: a Pilot Study
People who do not have adequate amounts of vitamin D develop weakness of leg and arm muscles. This study will determine if vitamin D supplementation benefits muscle functions important for swallowing, bladder and bowel function.
- Conditions
- Dysphagia, Fecal Incontinence, Urinary Incontinence
- Trial name
- NCT00593996
- Testing
- Ergocalciferol (vitamin D2)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Dysphagia
Chewing and Oral Processing of Solid Food
Food texture modification is commonly used as an intervention for people with dysphagia (swallowing impairment). However, the field currently lacks a proper understanding of how this intervention works.
- Trial name
- NIH_HVX6 (NCT05594173)
- Testing
- Food texture modification
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Opioid Induced Pharyngeal and Esophageal Dysfunction
Opioid Effects on Swallowing and Esophageal Sphincter Pressure
The purpose of this study is to determine whether a dopamine receptor antagonist metoclopramide can counteract opioid induced effects on esophageal motility and lower esophageal sphincter.
- Trial name
- NCT01191645
- Testing
- naloxone, remifentanil, Sodium Chloride
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Gastroesophageal Reflux Disease
Drug Interaction Study Between AZD3355 and Nexium
The purpose of the study is to evaluate if AZD3355 and Nexium interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.
- Trial name
- NCT00684190
- Testing
- AZD3355, Esomeprazole
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Barrett Esophagus, Gastroesophageal Reflux
Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test.
- Conditions
- Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
- Trial name
- NCT06687603
- Testing
- EsoCheck, EsoGuard
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Degeneration Spine, Cervical Radiculopathy
Salt Water Gargling on Swallowing Following ACDF
The goal of this randomized control trial is to collect sufficient preliminary data on the efficacy of sodium chloride, hereafter referred to as "saltwater" or "saline" in reducing the difficulty of swallowing following…
- Conditions
- Degeneration Spine, Cervical Radiculopathy, Cervical Stenosis, Cervical Spondylosis
- Trial name
- NCT06475365
- Testing
- Sodium chloride gargle
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Dysphagia, Swallowing Disorders
Motor Learning in Dysphagia Rehabilitation
The overall goal is to exploit motor learning principles and adjuvant techniques in a novel way to enhance dysphagia rehabilitation.
- Conditions
- Dysphagia, Swallowing Disorders, Deglutition Disorders, Stroke
- Trial name
- NCT02576470
- Testing
- Biofeedback, Transcranial Direct Current Stimulation, Financial Reward
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Florida
Anterior Cervical Pain
The Effect of the Transection of the Omohyoid in the Incidence of Dysphagia in Patients
The investigators believe that the transection of the omohyoid during an anterior cervical discectomy and fusion decreases the incidence of dysphagia in patients who undergo this procedure when compared to patients who do not…
- Trial name
- NCT06482632
- Testing
- Discectomy of Omohyoid, Control group no discectomy of Omohyoid
- Where
- Puerto Rico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Esophageal Dysmotility
Topical Bethanechol for Improvement of Esophageal Dysmotility
The purpose of this research project is to determine the effect of a drug called bethanechol on swallowing function in patients with Ineffective Esophageal Motility (IEM).
- Trial name
- NCT01031043
- Testing
- Bethanechol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Augusta University
Velopharyngeal Insufficiency, Swallowing
Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients
The aim of this study is to gain insight into the development of velopharyngeal insufficiency (VPI) in patients who have undergone maxillomandibular advancement osteotomy (MMA) as a treatment for obstructive sleep apnea syndrome…
- Conditions
- Velopharyngeal Insufficiency, Swallowing, Nasality, Speech
- Trial name
- VPIMMA (NCT07301021)
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)