Clinical trials: Delirium in Intensive Care Unit
Delirium, Anxiety
Patient- and Family-centred Care in the Adult Intensive Care Unit: a Feasibility Study
Background: In the intensive care unit (ICU), delirium in patients and long-term mental health challenges in both patients and their family members are highly prevalent.
- Conditions
- Delirium, Anxiety, Post Intensive Care Unit Syndrome, Post Intensive Care Unit Syndrome Family
- Trial name
- FAM-ICU (NCT06974214)
- Testing
- FAM-ICU
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Poor Quality Sleep, Sleep Deprivation
The Comparison of Dexmedetomidine and Midazolam for the Sleep in Intensive Care Unit
The investigators are going to compare the sleep quality and quantity between dexmedetomidine group and midazolam group using 24 hour polysomnography in critically ill patients.
- Conditions
- Poor Quality Sleep, Sleep Deprivation, Sleep Arousal Disorders, Delirium
- Trial name
- NCT01966315
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Hospital
Delirium in the Intensive Care Unit
Nurse-Led Implementation of the ABCDEF Bundle
This study evaluated the effectiveness of a nurse-led implementation of the ABCDEF bundle, an evidence-based, interprofessional care framework, in the prevention and management of delirium among Intensive Care Unit (ICU)…
- Trial name
- NCT07054268
- Testing
- Nurse-Led ABCDEF Bundle Implementation
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Helwan University
Intensive Care Unit Delirium
PRE-DELIRIC Prediction Model Plus SMART Care to Reduce the Incidence of Delirium in ICU Patients
Delirium is a severe acute brain dysfunction characterised by sudden confusion, inattention and fluctuating level of consciousness, which mainly affects intubated intensive care patients.
- Trial name
- NCT06279390
- Where
- Taiwan
- Volunteers
- 381 people
- Sponsor
- National Taiwan University Hospital
Delirium, Cognitive Impairment
Validation of the PreSchool Confusion Assessment Method for the Intensive Care Unit (psCAM-ICU)
The investigators hypothesize that critical care trained registered nurses and physicians can perform measurements of cognitive impairment in critically ill pediatric patients in a reliable and valid manner.
- Trial name
- NCT02481115
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Critical Illness, Delirium
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge.
- Conditions
- Critical Illness, Delirium, Cognitive Impairment, Cognitive Decline
- Trial name
- SLEEP-COG (NCT06411561)
- Testing
- SLEEP + COG, COG, SLEEP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Delirium
A Multidisciplinary Delirium Prevention Strategy Involving Psychiatry in the ICU
Delirium affects up to 80% of intensive care unit (ICU) patients and is associated with longer hospital stays, increased morbidity and mortality, and increased costs.
- Trial name
- ICU (NCT03550495)
- Testing
- psychiatry involvement
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Southern California
Delirium, Intensive Care Unit Delirium
PREdiction of DELIRium in Medical ICU Patients
In intensive care unit (ICU) patients, the ability to predict delirium may help reduce its incidence, duration, and severity. The PREdiction of DELIRium in ICU (PRE-DELIRIC) model was recently developed for this purpose.
- Trial name
- NCT04218461
- Testing
- PRE-DELIRIC model
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Istanbul Demiroglu Bilim University
Mechanically Ventilated Patients
Prevention of Delirium in Intensive Care by Melatonin
This is a double-blind, randomized, placebo-controlled, Phase 2b/3 two-part adaptive clinical trial. The trial is designed to investigate the pharmacokinetics and the efficacy of multiple dosing regimens of melatonin and to…
- Trial name
- DEMEL (NCT03524937)
- Testing
- MELATONIN (HIGH DOSE), MELATONIN (LOW DOSE)
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium
Using Eye Mask and Earplugs on Prevention of Delirium
This research is planned as a randomized controlled experimental study to examine the effect of using eye mask and earplugs in preventing delirium with evidence-based nonpharmacological nursing interventions in intensive care…
- Trial name
- NCT05000476
- Testing
- eye mask and earplugs, Nurse Education and Environmental Regulation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Delirium, Sleep Disorders, Circadian Rhythm
Study of Sleep and Delirium in the Intensive Care Unit (ICU)
The investigators will perform a prospective, cohort study of 100 older intensive care unit (ICU) patients, to investigate the association between sleep disruption and ICU delirium.
- Trial name
- SID (NCT01280097)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Francisco
Delirium, Sedation
Neurosteer Bedside Monitoring System
The purpose of this study is to evaluate the clinical utility of Neurosteer's brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients.
- Conditions
- Delirium, Sedation, Agitation
- Trial name
- NCT06718764
- Testing
- Neurosteer's single-channel EEG monitoring device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Noise in the ICU, Sleep Quality in Adult ICU Patients
Noise in the Intensive Care Unit
Rationale: Sound levels in the Intensive Care Unit are frequently reported to exceed the recommended levels. It is plausible to assume that this causes sleep disturbance in the patients on the ICU.
- Trial name
- NCT01826799
- Where
- 6 sites in Netherlands
- Volunteers
- 75 people
- Sponsor
- Jeroen Bosch Ziekenhuis
Delirium
Postoperative Delirium in Cardiac Surgery ICU
Postoperative Delirium (POD) is a common complication in patients after cardiac surgery, which is associated with short-term prognosis and long-term quality of life.
- Trial name
- NCT04527341
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium in the Intensive Care Unit
Methadone vs. Transdermal Fentanyl for Opioid Withdrawal Syndrome
Many patients in the general intensive care unit experience pain, as a result of an injury or underlying disease, surgery or an invasive procedure.
- Trial name
- NCT05697783
- Testing
- Administration of methadone instead of fentanyl patch
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Intensive Care Unit Delirium, Postoperative Delirium
Role of Natural Light in the Prevention of Delirium After Cardiac Surgery: a Prospective Observational Study With Historical Control
Postoperative delirium is a common complication that usually occurs acutely within the first 24 hours after surgery and resolves within 72 hours; it is common in all medical areas and particularly affects patients over the age of…
- Conditions
- Intensive Care Unit Delirium, Postoperative Delirium, Cardiac Surgery
- Trial name
- iWOnDer (NCT05936944)
- Testing
- Exposure to totally artificial lighting
- Where
- Italy
- Volunteers
- 448 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Noise Exposure, Sedative Withdrawal Delirium
Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate
There is limited data regarding sound levels and burden in the pediatric cardiac critical care unit and how this compares with WHO standards.
- Conditions
- Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
- Trial name
- NCT04777695
- Testing
- Decibel Monitor
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Pediatric Delirium
Delirium Assessment in the Pediatric Intensive Care Unit
Objective: Studies documenting the prevalence of delirium among critically ill children are still rare. Emerging literature from psychiatric specialists reports the prevalence of delirium to be approximately 10% in the pediatric…
- Trial name
- DIPI-ICU (NCT01416675)
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Charite University, Berlin, Germany
Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium
Efficacy of the "Start to Move" Protocol on Functionality, Delirium and Acquired Weakness in ICU
Background: ICU hospitalization is associated with loss of strength, functionality and delirium. The "Start to Move protocol" demonstrated efficacy in improving and minimizing such effects.
- Conditions
- Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium, Intensive Care Neuropathy, Intensive Care Unit Syndrome
- Trial name
- STM (NCT05053724)
- Testing
- Star to move Protocol
- Where
- Chile
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Hospital Felix Bulnes