Clinical trials: Delivery Systems
Hemorrhage, Premature Infants
NIRS Monitoring in Premature Infants
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for…
- Conditions
- Hemorrhage, Premature Infants, Newborn, Hydrocephalus
- Trial name
- NCT02601339
- Testing
- ETV/CPC
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Microbicide Delivery System Perceptibility and Acceptability
Developing Rectal USPE Measures for Suppositories (Project DRUM-S)
The purpose of this study is to (a) adapt existing user sensory perception and experience (USPE) items/instruments generated for rectal gel/cream formulations to include USPEs specific to suppository forms for rectal and vaginal…
- Trial name
- DRUM-S (NCT02744261)
- Testing
- Gel, Suppository 1, Suppository 2
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Healthy Volunteers
Blinding Integrity Assessment Using Rotational Field Transcranial Magnetic Stimualtion (rfTMS) in Healthy Adults
This study evaluates the effectiveness of an improved blinding method using rotational field transcranial magnetic stimulation (rfTMS) delivered through a multi-channel deep coil system (Brainsway, Jerusalem, Israel).
- Trial name
- NCT07706790
- Testing
- Active rfTMS
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Cataract After
Patient Acceptability of Autonomous Telemedicine
Patients will have an automated call supervised by a human clinician to check how they are after uncomplicated cataract surgery as part of their standard of care.
- Trial name
- NCT04885868
- Testing
- This study assess acceptability of autonomous conversation as part of cataract surgery follow up.
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ufonia
Premature Birth, Newborn
Pain Management in Neonatal Intensive Care Units by Studying the Autonomic Balance
Fight against the pain caused by the disease or by the diagnostic and therapeutic procedures is a daily and essential concern for the caregiver neonatologist.
- Trial name
- NIPE-DOL (NCT02764424)
- Testing
- NIPE (MDoloris®)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy Volunteers, Recurrent Glioma
MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors
This first-in-human study will establish the human safety and radiation dosimetry of the system A amino acid transport substrate, (R)-3-[F-18]fluoro-2-methyl-2-(methylamino)propanoic acid ([F-18]MeFAMP), for positron emission…
- Conditions
- Healthy Volunteers, Recurrent Glioma, Brain Metastases From Extra-cranial Solid Tumors
- Trial name
- NCT05676489
- Testing
- [F-18]MeFAMP PET
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain Management, Birth Comfort
Sacral Massage With a Tennis Ball on Labor Pain and Comfort During the Intrapartum Period
Although pregnancy and labor are physiological events, the pain caused by uterine contractions during labor is among the most severe pains. This causes many women to fear labor.
- Conditions
- Pain Management, Birth Comfort, Massage Effect, Labor Pain
- Trial name
- NCT06898580
- Testing
- sacral massage with tennis ball
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Electronic Cigarette Use
Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems
This is a randomized, parallel-group open-label trial to evaluate respiratory symptoms in ENDS users switching from banned flavors to a non-banned flavor (tobacco) or 'tobacco free' nicotine pouches.
- Trial name
- CRoFT (NCT05423340)
- Testing
- E-cigarette Flavor, Tobacco Free Nicotine Pouch
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Halitosis, Gingivitis
Day Long Prevention of Oral Malodor With a Palatal Patch (SmellX) Containing A Herbal Formula
In a previous study the prevention of halitosis by the herbal formula and delivery system (SmellX), were established both in vitro and clinicaly. The duration of relief was established as long as 8 hours.
- Trial name
- SmellX (NCT01388023)
- Testing
- herbal formula for fresh breath
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Asthma
Study to Evaluate the Pharmacokinetic Profile of Salbutamol Delivered by Unit Dose Dry Powder Inhaler (UD-DPI) Compared to the Diskus and Metered Dose Inhaler (MDI) in Healthy Volunteers.
This is an open-label, two part, six period- cross over, randomised, single dose, single centre study in healthy subjects. This is the first clinical study for the UD-DPI. This study is divided into two parts.
- Trial name
- NCT01984086
- Testing
- Salbutamol Sulphate 150mcg UD-DPI Blister(1.6% blend), Salbutamol Sulphate 200mcg UD-DPI Blister(1.6% blend), Salbutamol Sulphate 250mcg UD-DPI Blister(1.6% blend)
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Postoperative Pain, Acute, Postoperative Depression
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving…
- Conditions
- Postoperative Pain, Acute, Postoperative Depression, Anxiety, Sleep Disturbance
- Trial name
- NCT05625360
- Testing
- eHealth Mindful Movement and Breathing, Life Impacts Reflection, PROMIS Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Dementia
Learn About Caring for a Person Living With Dementia
The goal of is project is to improve caregiver education about the behavioral and psychological symptoms (BPSD) of dementia. This intervention will incorporate principles from the science of learning for structuring retrieval…
- Trial name
- NCT07381010
- Testing
- Structured Retrieval Practice (SRP), Standard Health Education
- Where
- 2 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Muscle Weakness, Vitamin D Deficiency
Vitamin D and Physical Performance Before and After Intervention and Birth Outcome in Pregnant Somali and Swedish Women
Somali migrant women, often in veiled clothing, living in a town in mid Sweden on the 60:th parallel were observed to be weak and to have a waddling gate.
- Trial name
- NCT02922803
- Testing
- 1 combination tablet of Vitamin D3/calcium per day, 2 combination tablets of Vitamin D3/calcium per day
- Where
- Sweden
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Thyroid, Gland; Functional Disturbance
Ultrasound and Functional Thyroid Evaluation
Thyroid disorders are most commonly concomitant with prematurity and still remains a controversial topic. The incidence of a temporary form of hypothyroidism among preterm neonates is higher than in the general population.
- Trial name
- NCT04208503
- Testing
- thyroid ultrasound
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Adipose Tissue
Autologous Fat Grafting to the Face With Use of the Viality™ System
The purpose of this research is to collect data on the short and long-term effects of facial fat grafting by injectable tissue replacement and regeneration in the midfacial zone, with the use of the VialityTM system.
- Trial name
- NCT06169670
- Testing
- Viality
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tiger Biosciences, LLC.
Nicotine Use Disorder, Tobacco Use Disorder
Evaluation of the Addictive Potential of E-Cigarettes
This study will examine the subject matter from a neurobiological and a neuropsychological vantage point to ascertain whether the e-cigarette is potentially as addictive as the traditional tobacco cigarette.
- Trial name
- EVAPE (NCT04772014)
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Postoperative Pain
Postoperative Analgesia in Cesarean Delivery
İn this study, planned to compare the post-operative analgesic efficacy of Ilioinguinal iliohypogastric (II-IH) nerve block and Quadratus lumborum III Block in elective cesarean section operations.
- Trial name
- NCT06010602
- Testing
- Quadratus lumborum block, İlioinguinal-İliohipogastric nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Dietary Modification, Weight Loss
Feasibility of a Postpartum Lifestyle Intervention on the Cardiometabolic Risk Profile of GDM Women
The goal of the study is to investigate the effect of a lifestyle intervention program (adoption of exclusive breastfeeding, healthy diet and regular physical activity) on minimizing postpartum weight retention among women with…
- Conditions
- Dietary Modification, Weight Loss, Physical Activity, Breastfeeding
- Trial name
- DEPART (NCT02872402)
- Testing
- Lifestyle intervention, Active control lifestyle intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laval University