Clinical trials: Dementia, completed
Alzheimer's Disease, Mild Cognitive Impairment
Performance of AclarusDx™, a Blood-Based Transcriptomic Test for AD, in US Patients Newly Referred to a Memory Center
The purpose of this study is to assess the performance of AclarusDx™, an investigational blood test detecting gene expression information, and intended to help physicians in making an Alzheimer's Disease diagnosis in patients…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Fronto-temporal Dementia
- Trial name
- NCT01465360
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- Exonhit
Alzheimer Disease
Physical Exercise as an Additional Treatment for Alzheimer Disease
The state of the art with regard to the neurodegenerative dementias, especially for Alzheimer´s disease (AD), is that their progression is still irreversible causing cognitive, motor, and behavioral impairment.
- Trial name
- NCT01515982
- Testing
- Aerobic Exercise, Control Group
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Alzheimer's Disease
Specific Care and Assistance Plan for Alzheimer's Disease
The main objective of this work is to assess the feasibility and efficacy of a specific Care and Assistance Plan for Alzheimer's disease (PLASA).
- Trial name
- PLASA (NCT00480220)
- Testing
- Global care and support program
- Where
- 40 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Toulouse
Huntington's Disease
Effects of Music Therapy on Huntington's Disease
The purpose of this study is primarily to assess the ability of a music therapy program to improve holistically the psychological, somatic, and social symptoms of patients with Huntington 's disease (HD).
- Trial name
- NCT00178360
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Alzheimer Disease
Utilizing Palliative Leaders In Facilities to Transform Care for Alzheimer's Disease
The purpose of this study is to evaluate a comprehensive model for integrating both primary and specialty Palliative Care for older adults with dementia into nursing facilities.
- Trial name
- UPLIFT-AD (NCT04520698)
- Testing
- UPLIFT-AD
- Where
- United States
- Volunteers
- 1,322 people
- Sponsor
- Indiana University
Frailty Syndrome, Dementia
The Impact of Transcutaneous Vagal Nerve Stimulation on Frailty Syndrome in Older Adults
This clinical study, conducted at the Techirghiol Balneary and Rehabilitation Sanatorium, aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in improving clinical and biological…
- Trial name
- NCT07416708
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Physiotherapy
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
Dementia Alzheimers
Alzheimer's Family Caregiver Intervention in Vietnam
This is a single arm pilot study of 6-8 families to test the feasibility and acceptability of a Alzheimer's family caregiver intervention in Vietnam.
- Trial name
- NCT03100617
- Testing
- Psychosocial caregiver intervention
- Where
- Vietnam
- Volunteers
- 6 people
- Sponsor
- University of California, Davis
Alzheimer Disease
PET Study With 11 C-PIB to Evaluate Amyloid Protein Deposits in Mild Cognitive Disorder, Alzheimer's Disease and Early Frontotemporal Degeneration.
Preclinical and clinical data have demonstrated the ability of the 11C-PIB tracer to selectively bind accumulations of amyloid protein, a neuropathological marker characteristic of the neurodegenerative pathologies covered by…
- Trial name
- NCT06179979
- Testing
- PET/CT with 11C-PiB
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Dementia
Cognitive Stimulation Therapy for Dementia
Aim: The aim of this study is to reveal the effectiveness of cognitive stimulation therapy on activities of daily living, depression and life satisfaction in individuals with mild dementia living in nursing homes.
- Trial name
- NCT05514678
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ejdane Coskun
Conduct Disorder, Antisocial Behavior
The Effectiveness of Forensic Outpatient Systemic Therapy: a Multiple Case Experimental Design
The purpose of this study is to investigate the effectiveness and mediators of Forensic Outpatient Systemic Therapy (FAST).
- Conditions
- Conduct Disorder, Antisocial Behavior, Aggression, Behavioral Disorder
- Trial name
- FAST (NCT06032520)
- Testing
- FAST
- Where
- 2 sites in Netherlands
- Volunteers
- 21 people
- Sponsor
- Utrecht University
Psychiatric &or Mood Disorder
Effect of Massage Therapy on Aggression in a Psychiatric Inpatient Unit
The purpose of this study is to investigate whether relaxation massage therapy is effective in reducing the levels of arousal and aggression on a young adult inpatient unit.
- Trial name
- NCT00421070
- Testing
- Massage therapy
- Where
- Australia
- Volunteers
- 47 people
- Sponsor
- Melbourne Health
Dementia Alzheimers
Dementia Risk Prediction Model: Development and Validation
At present, there is no treatment for dementia that changes the course of the disease. However, it is now understood that the proteins in dementias such as Alzheimer's disease are present years before someone develops symptoms of…
- Trial name
- NCT03943641
- Testing
- This is not an intervention study
- Where
- United Kingdom
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Alzheimer's Disease
A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy
This Phase II, multicenter, randomized, double-blind, parallel-group, placebo-controlled study will evaluate the efficacy and safety of RO4602522 in participants with moderate severity Alzheimer's disease.
- Trial name
- MAyflOwer RoAD (NCT01677754)
- Testing
- RO4602522, Donepezil, Memantine
- Where
- 142 sites in United States, Australia and 10 more
- Volunteers
- 542 people
- Sponsor
- Hoffmann-La Roche
Alzheimer's Disease
Study of 50561 in Patients With Mild or Moderate Alzheimer's Disease
This is a multi-center, Phase IIa, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy, safety of two doses of 50561 compared to placebo in participants diagnosed with mild to moderate Alzheimer's…
- Trial name
- NCT05811442
- Testing
- 50561 high dose, 50561 low dose
- Where
- 12 sites in China
- Volunteers
- 68 people
- Sponsor
- Beijing Joekai Biotechnology LLC
Alzheimer Disease
Evaluation of Self-Mediated Alternatives for Risk Testing Education and Return of Results
This randomized non-inferiority study will evaluate self-directed scalable electronic health platform (eHealth) methods for communicating Alzheimer's gene and biomarker results compared to videoconference telehealth disclosure…
- Trial name
- eSMARTER (NCT06459583)
- Testing
- eHealth Platform, Videoconference Telehealth Platform
- Where
- 2 sites in United States
- Volunteers
- 681 people, healthy volunteers welcome
- Sponsor
- Banner Health
Age-Related Memory Disorders
Effectiveness of a Cognitive Training Program (UMAM Method) in Elderly People Without Dementia
The study is oriented to analyze the effectiveness of a cognitive training method (UMAM) on cognitive functions, subjective memory and mood state in elderly people without dementia.
- Trial name
- NCT04245579
- Testing
- Multifactorial Memory Training Program (UMAM method)
- Where
- Spain
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Madrid Salud
Primary Progressive Aphasia, Frontotemporal Dementia
Long-term Effect of TMS in Primary Progressive Aphasia
There are very few treatments for neurodegenerative disorders, and the efficacy of these treatments is generally modest. Recent studies have shown a short-term positive effect of non-invasive neuromodulation techniques such as…
- Conditions
- Primary Progressive Aphasia, Frontotemporal Dementia, Alzheimer Disease
- Trial name
- RECONNECT (NCT05842473)
- Testing
- Transcranial Magnetic Stimulation (active), Language therapy
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Hospital San Carlos, Madrid
Dementia, Alzheimer Disease
The Brain Health Study: A Pragmatic, Patient-Centered Trial
The eRADAR Brain Health Study is an embedded, pragmatic clinical trial to determine whether targeted screening for dementia using the eRADAR algorithm increases dementia detection within primary care compared to usual care.
- Trial name
- eRADAR (NCT05905796)
- Testing
- Brain Health Assessment
- Where
- 3 sites in United States
- Volunteers
- 1,261 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cognitive Decline, Cognitive Dysfunction
Brain Vascular and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of transcranial photobiomodulation on indices of cerebral vascular health and neurocognitive function.
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Alzheimer Disease, Vascular Disease, Peripheral
- Trial name
- NCT06497413
- Testing
- Transcranial Photobiomodulation, Transcranial Photobiomodulation helmet (Neuradiant 1070 Plus) with no light administered
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Alzheimer's Disease
Evaluation of [18F]RO6958948 as Tracer for Positron Emission Tomography (PET) Imaging of Tau Burden in Alzheimer's Disease Participants
This is a longitudinal, follow-up study in participants with Alzheimer's disease (AD) who previously participated in study BP29409 (NCT02187627).
- Trial name
- NCT02792179
- Testing
- [18F]RO6958948
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Hoffmann-La Roche
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