Clinical trials: Dementia Alzheimers
Alzheimer Disease
The Dementia Study in Northern Norway
The Dementia Study in Northern Norway is an open controled intervention trial carried out in nine rural municipalities, five of which allocated to intervention and four to control.
- Trial name
- NCT00443014
- Testing
- Cognitive, physical and social stimulation
- Where
- Norway
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Gynecologic Cancer, Gynecologic Neoplasm
The Lifestyle and Empowerment Techniques in Survivorship of Gynecologic Oncology Study
This study compares traditional follow-up of gynaecological cancer patients to an alternative follow-up model. In the alternative follow-up model the patients will meet a nurse at every second consultation.
- Conditions
- Gynecologic Cancer, Gynecologic Neoplasm, Ovarian Cancer, Endometrial Cancer
- Trial name
- LETSGO (NCT04122235)
- Testing
- LETSGO follow-up
- Where
- 12 sites in Norway
- Volunteers
- 755 people
- Sponsor
- Sorlandet Hospital HF
Alzheimer's Disease
Computer-Based Training for Mild Alzheimer's Disease
The primary objective of this study is to evaluate the effects of computer-based training program ("HiFi-AD") on the memory and cognitive abilities of individuals diagnosed with mild Alzheimer's Disease (AD).
- Trial name
- NCT00319891
- Testing
- Computer-based Cognitive Training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Posit Science Corporation
Alzheimer's Disease
Long Term Extension Study Evaluating Safety, Tolerability And Immunogenicity Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's Disease
The purpose of this long term extension study is to assess safety, tolerability and immunogenicity of ACC-001 with QS-21 adjuvant in Japanese subjects with mild to moderate AD who were randomized in the preceding P2 double blind…
- Trial name
- NCT01238991
- Testing
- ACC-001
- Where
- 11 sites in Japan
- Volunteers
- 53 people
- Sponsor
- Pfizer
Alzheimer Disease
Effect of Music Therapy on Anxiety of Caregivers of Alzheimer's Disease Patients
This clinical trial evaluates the impact of music interventions on caregivers of patients with memory disorders, Alzheimer's disease, dementia and related disorders.
- Trial name
- NCT05317910
- Testing
- MUSIC CARE
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Association de Musicothérapie Applications et Recherches Cliniques
Alzheimer's Disease in Down Syndrome
Down Syndrome Clinical Trials - Study of Alzheimer's Disease in Down Syndrome
The primary objective is to characterize trajectories of change on the primary outcome measures in this study population through longitudinal collection of measures of cognition, function, behavior, and health status.
- Trial name
- LIFE-DSR (NCT04149197)
- Where
- 14 sites in United States
- Volunteers
- 252 people
- Sponsor
- LuMind IDSC Foundation
Memory Loss (Excluding Dementia), Lifestyle (Sedentary Behavior and Physical Activity)
Pilot Study of a Brain Health Program in Senior Centers
The investigators will evaluate a brain health programs in older adults with subjective cognitive decline. The primary aim of the study is to determine the credibility, expectancy, feasibility, acceptability, appropriateness…
- Conditions
- Memory Loss (Excluding Dementia), Lifestyle (Sedentary Behavior and Physical Activity), Lifestyle Risk Reduction, Healthy Lifestyle Behaviors
- Trial name
- NCT07424443
- Testing
- My Healthy Brain
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease
Study Evaluating Safety, Tolerability and Pharmacokinetics of Single and Multiple Dose of SAM-531
The main objectives of this study is to assess the safety and tolerability of ascending single and multiple oral doses of SAM-531 in healthy subjects
- Trial name
- NCT00726115
- Testing
- SAM-531
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Mild Cognitive Impairment (MCI), Amnestic Mild Cognitive Impairment - aMCI
Auditory Stimulation During Sleep to Enhance Long-Term Memory in Amnestic MCI
This study aims to evaluate the efficacy and safety of Elevvo AudiStim, a sleep auditory stimulation device, as a symptomatic treatment for patients with amnestic mild cognitive impairment (aMCI).
- Conditions
- Mild Cognitive Impairment (MCI), Amnestic Mild Cognitive Impairment - aMCI, Alzheimer or Mild Cognitive Impairment
- Trial name
- NCT07402590
- Testing
- Auditory Stimulation
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Bitbrain
Insomnia Chronic
Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers
Treatment of insomnia in caregivers is needed given that 60% of Alzheimer disease caregivers report sleep complaints, and insomnia may add to the burden of AD caregiving and contribute to morbidity and mortality risk.
- Trial name
- CARES (NCT03538574)
- Testing
- CBT-I, MAP-I
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of California, Los Angeles
Alzheimer's Disease (AD) and Related Disorders
Longitudinal Study of Brain Amyloid imaGing in MEMENTO
A Multicenter national longitudinal cohort study including at least 800 individuals consecutively recruited from French Research Memory Centers and followed-up over 24 month and included in Memento.
- Trial name
- MEMENTOAmyGing (NCT02164643)
- Testing
- Flutemetamol (18F), Florbetapir (18F)
- Where
- 26 sites in France
- Volunteers
- 448 people
- Sponsor
- University Hospital, Bordeaux
Healthy Volunteers, Alzheimer Disease
Phase 1 Test-retest Evaluation of [18F]MNI-958 PET
The overall goal of this protocol is to evaluate [18F]MNI-958 also known as APN-0000455 or PM-PBB3, a tau targeted radiopharmaceutical.
- Conditions
- Healthy Volunteers, Alzheimer Disease, Progressive Supranuclear Palsy
- Trial name
- NCT03545789
- Testing
- [18F]MNI-958
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Invicro
Alzheimer Disease
A Phase I Clinical, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Donepezil Patch in Healthy Male Subjects
Study of the Safety, tolerability and pharmacokinetics with single dose of donepezil patch in healthy male subjects.
- Trial name
- NCT01860625
- Testing
- Donepezil patch
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Icure Pharmaceutical Inc.
Alzheimer Disease
Study to Evaluate Dietary Supplementation With a Version of Anatabloc(R) in Subjects With Alzheimer's Disease
To explore whether dietary supplementation with a version of Anatabloc(R) exerts an effect on blood levels of amyloid beta (Aβ), or impacts global or functional measures of Alzheimer's Disease (AD) in subjects with mild to…
- Trial name
- ASAP (NCT01669876)
- Testing
- Anatabloc(R)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Rock Creek Pharmaceuticals, Inc.
Alzheimer's Disease
Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects
A second-generation tau PET image tracer 18F-PM-PBB3 (APN-1607 or MNI-958) has been developed by National Institute of Radiological Sciences. The new tracer solved the off-target binding issue.
- Trial name
- NCT04169126
- Testing
- F-18 PMPBB3
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer's Disease
A 6-Month Study to Evaluate the Safety & Potential Efficacy of Trappsol Cyclo in Patients With Early Alzheimer's Disease
Approximately 90 patients, aged 50 to 80 years, with a diagnosis of early Alzheimer's disease will take part in this research study. This study will be conducted in the US.
- Trial name
- EAD501 (NCT05607615)
- Testing
- Hydroxypropyl Beta Cyclodextrin
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- Cyclo Therapeutics, Inc.
Neurodegenerative Diseases, Memory Disturbances
Health Technology Assessment of Diagnostic Approaches in Alzheimer's Disease
Background: New research criteria for the diagnosis of Alzheimer's disease (AD) have recently been developed to enable an early diagnosis of AD pathophysiology by relying on emerging biomarkers.
- Trial name
- NCT01450891
- Where
- 4 sites in Netherlands
- Volunteers
- 304 people
- Sponsor
- Maastricht University Medical Center
MCI
BRain Energy Activation With Ketones to Prevent Alzheimer's Disease
A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS).
- Trial name
- BREAK-AD (NCT04466735)
- Testing
- Active group
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Alzheimers Disease
Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability, immunogenicity, pharmacokinetics, and pharmacodynamics of multiple-ascending intravenous (IV) doses of RO7126209 in participants with prodromal or mild to…
- Trial name
- NCT04639050
- Testing
- RO7126209
- Where
- 37 sites in United States, Australia and 7 more
- Volunteers
- 241 people
- Sponsor
- Hoffmann-La Roche
Alteration of Cognitive Function, Hypoxia
Effect of Hypoxia on Cognitive Assessment and Cerebral Activity in Healthy Volunteers
The early assessment of new symptomatic drugs for Alzheimer disease remains difficult because of the lack of predictive end-point. The use of a battery including different parameters could improve this early development.
- Trial name
- Hypoxia (NCT02891343)
- Testing
- 2-hour period of hypoxia
- Where
- 2 sites in France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
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