Clinical trials: Dementia Severe
Aggression, Self-Injurious Behavior
Treatment of Severe Destructive Behavior: FCT Versus Wait-List Control
Children with an intellectual disability often display severe destructive behavior (e.g., aggression, self-injury) that pose risks to themselves or others and represent barriers to community integration.
- Trial name
- NCT02483572
- Testing
- Functional Communication Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Nebraska
Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD)
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
The first aim of the observational study is the translation, cross-cultural adaptation and validation of functional and behavioral scales used in the diagnosis of neurodegenerative diseases, for which a formal version in Italian…
- Conditions
- Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Major Neurocognitive Disorder
- Trial name
- ITA-VALI-DEM (NCT06701630)
- Where
- Italy
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Casa di Cura IGEA
Dementia, Dysphagia
Family Caregiver Online Survey (Dementia and Swallowing Difficulties)
The Family Caregiver Survey is a one-time, 30-minute, online survey for people living with and caring for a family member with dementia.
- Conditions
- Dementia, Dysphagia, Dementia Alzheimers, Dementia, Vascular
- Trial name
- NCT06471660
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Neuromuscular Diseases, Obesity (Disorder)
Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology
The ActiLiège-Adult study is a prospective, longitudinal, observational study designed to collect natural history data on adult patients with neurological or metabolic diseases affecting movement.
- Conditions
- Neuromuscular Diseases, Obesity (Disorder), Myotonic Dystrophy 1, Myasthenic Syndrome
- Trial name
- Acti-Adult (NCT07136844)
- Testing
- Syde, Dynamometric measurements of muscle strength, The 6-minute walk test (6MWT)
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Dementia, Inappropriate Prescribing
An Intervention to Reduce Inappropriate Medications in Long-term Care Residents With Severe Dementia
An education intervention to promote medication reviews and interdisciplinary discussions within long-term care facilities with the aim of improving medication regimen among residents with severe dementia
- Trial name
- OptimaMed (NCT03539276)
- Testing
- Knowledge exchange
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- CHU de Quebec-Universite Laval
Major Depression, Dementia
Neurocognitive Outcomes of Depression in the Elderly
Late-life depression (LLD) and cognitive impairment (CI) are significant public health problems among older adults, and their co-occurrence markedly increases disease burden and dementia risk.
- Trial name
- NCODE (NCT00570583)
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimer Disease, Schizophrenia
Multi-center Imaging Genetics Studies in China
To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.
- Conditions
- Alzheimer Disease, Schizophrenia, Major Depressive Disorders
- Trial name
- CHIMGEN (NCT02681822)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Dementia, Mood
Bright Light Therapy in Older Adults With Moderate to Very Severe Dementia
INTRODUCTION: Bright light therapy (BLT) has demonstrated positive effects on sleep, mood, and behavioral problems in older adults with dementia. However, there is little research in people with advanced stages of dementia.
- Conditions
- Dementia, Mood, Behavior
- Trial name
- BLT-Dementia (NCT04949984)
- Testing
- Bright light therapy
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Universidade da Coruña
Mentalizing Imagery Therapy, Relaxation Recording
Meditation for Dementia Caregivers Major Depressive Disorder in Family Dementia Caregivers
Family dementia caregivers provide a needed service to relatives with dementia and to society, but are often at risk for consequences to their own health such as depression, reduced immune system function, and burnout.
- Trial name
- NCT02122068
- Testing
- Mentalizing Imagery Therapy, Relaxation cd
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Major Neurocognitive Disorder
Cross-cultural Adaptation of the Safety Assessment Scale for Elderly People With a Major Neurocognitive Disorder Living at Home.
The main objective of this study is to adapt the Canadian French version of the safety assessment scale for use in France. The Safety Assessment Scale was developped for community healthcare providers working with elderly people…
- Trial name
- ESTRAD (NCT05485090)
- Testing
- Questionnaire : Adapted Safety Assessment Scale
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Patient Engagement, Behavioral Symptoms
How to Bathe a Person With Dementia? A Bathing Intervention Based on Basale Stimulation® for People With Moderate to Severe Dementia
Brief summary Resisted behaviours that occur during showering of People with Dementia (PwD) cause greater discomfort for caregivers and may occur as a result of embarrassment and shame that the person with dementia may be…
- Trial name
- NCT05353049
- Testing
- Bathing technique based on Basale Stimulation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Salamanca
Alzheimer s Disease, Major Depressive Disorder (MDD)
VR Pupillometry in Cognitive Impairment
With disease-modifying therapies emerging for dementia and related conditions, identifying cognitive decline as early as possible is increasingly important.
- Conditions
- Alzheimer s Disease, Major Depressive Disorder (MDD), Mild Cognitive Impairment, Dementia
- Trial name
- NCT07402356
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry
Alzheimer's Disease
Safety and Efficacy of Donepezil HCl 23 mg in Patients With Moderate to Severe Alzheimer's Disease
This is a multi-center, open-label, single-arm, prospective, phase IV trial, evaluating safety and efficacy of donepezil hydrochloride in patients with moderate to severe Alzheimer's disease.
- Trial name
- SAVE (NCT02097056)
- Testing
- Donepezil HCL
- Where
- 13 sites in South Korea
- Volunteers
- 171 people
- Sponsor
- Eisai Korea Inc.
Depression, Dementia
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)
The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in…
- Conditions
- Depression, Dementia, Mild Cognitive Impairment, Treatment Resistant Depression
- Trial name
- ONR (NCT05531591)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion
- Where
- 4 sites in United States, Canada
- Volunteers
- 87 people
- Sponsor
- Centre for Addiction and Mental Health
Dementia
A Study to Compare Genetic Variations of IGF-I and IGF-II
The purpose of this study is to determine if insulin-like growth factors (IGF) play a role in the development of dementia, specifically Alzheimer's disease (AD).
- Trial name
- NCT01329523
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Avera McKennan Hospital & University Health Center
Dementia, Agitation
Virtual Reality to Advance Dementia Care and Quality of Life
The goal of this feasibility clinical trial is to learn whether supervised virtual reality (VR) sessions can be safely and practically provided to adults aged 55 years and older with moderate-to-severe dementia who experience…
- Conditions
- Dementia, Agitation, Behavioural and Psychological Symptoms of Dementia, Major Neurocognitive Disorder
- Trial name
- VR-Care (NCT07893678)
- Testing
- Supervised Virtual Reality Sessions
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Major Depressive Disorder (MDD), Schizophenia Disorder
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for…
- Conditions
- Major Depressive Disorder (MDD), Schizophenia Disorder, Bipolar 1 Disorder, Alzheimer Disease
- Trial name
- Synapsing-SD (NCT07239843)
- Where
- Spain
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Postoperative Delirium, Cognitive Impairment
Postoperative Delirium in the ICU Setting of an Eastern European Centre
The study targets postoperative delirium in patients undergoing major abdominal surgery, with the aim to evaluate the functional baseline and proteomics implicated in pathogenesis, prevention strategies (such as anesthesia depth…
- Trial name
- NCT05474872
- Testing
- BIS monitoring
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Dementia, Bipolar Disorder (BD)
Lithium for Prevention of Cognitive Declining in Mood Illnesses
INTRODUCTION: Mood disorders, bipolar disorder and recurrent unipolar depression, are among the most common mental health conditions worldwide.
- Conditions
- Dementia, Bipolar Disorder (BD), Depression - Major Depressive Disorder, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06662526
- Testing
- Trace lithium dose plus treatment as usual
- Where
- 2 sites in Chile
- Volunteers
- 250 people
- Sponsor
- University of Chile
Major Neurocognitive Disorder, Alzheimer Disease
Exergaming Revolution in Dementia
This pilot randomized controlled trial evaluates the effect of a 12 weeks exergaming training in people with major neurocognitive disorders (MNCD) living in long-term care facilities.
- Conditions
- Major Neurocognitive Disorder, Alzheimer Disease, Parkinson Disease, Lewy Body Dementia
- Trial name
- GameDementia (NCT06631742)
- Testing
- Exergaming on Dividat Senso, Usual Care
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Eastern Switzerland University of Applied Sciences