Clinical trials: Demyelinating Disorders
Multiple Sclerosis
Gene Expression in MS Patients Before and During Treatment With Interferon-beta
Clinical and experimental evidences suggest that there is a variability in therapeutic response to immunomodulating therapies in Multiple Sclerosis patients.
- Trial name
- NCT00202384
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- S. Andrea Hospital
Multiple Sclerosis
Single Center, Open Label, Study of Preparation H on Erythema in Relapsing MS Patients Treated With PLEGRIDY
The primary purpose of this single center, randomized, open label study in relapsing Multiple Sclerosis (MS) patients on PLEGRIDY (peginterferon beta-1a) is to assess the effect of Preparation H (phenylephrine) Maximum Strength…
- Trial name
- NCT02665221
- Testing
- No Treatment Arm, Topical Preparation H arm
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Relapsing-Remitting Multiple Sclerosis
Assessment of Attentional and Executive Disorders in Multiple Sclerosis Using Techniques of Virtual Reality
Since many years cognitive disorders are a main topic of clinical research in Multiple Sclerosis (MS) as there could be observed early on in the disease and could induce with time in patients significant socio-professional…
- Trial name
- SEPREV (NCT01805336)
- Testing
- Assessment of attentional functions by traditional tests, Assessment of attentional functions by virtual reality tests, Assessment of executive functions by traditional tests
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Physical Therapy, Upper Extremity Function
Upper Extremity Function, Shoulder Position Sense and Disability Level İn Patients With Multiple Sclerosis
The purposes of this study is to investigate the relationship between upper extremity muscle function and shoulder position sense in patients with Multiple Sclerosis (MS) and which best projects the disability status.
- Conditions
- Physical Therapy, Upper Extremity Function, Position Sense
- Trial name
- NCT03846336
- Testing
- Upper extremity function, Shoulder position sense
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Multiple Sclerosis, Cognitive Impairment
Early Cognitive Impairment in Multiple Sclerosis
Cognitive impairment is one of the symptoms of Multiple Sclerosis (MS), and it may occur during the first years of the disease. It usually affects attention, information processing speed and short term memory.
- Trial name
- CogniSEP (NCT01157728)
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcopenic Obesity, Spinal Cord Injuries
Sarcopenic Obesity in Neurodisabilities
To describe the frequency and thresholds for sarcopenic obesity in neurodisabled persons and the fat and lean mass distribution based on various neurodisabilities
- Conditions
- Sarcopenic Obesity, Spinal Cord Injuries, Stroke, Multiple Sclerosis
- Trial name
- SarcObeNDS (NCT03863379)
- Testing
- whole body DXA
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dionyssiotis, Yannis, M.D.
Multiple Sclerosis - Relapsing Remitting, Clinically Isolated Syndrome, CNS Demyelinating
DTI in Children With Multiple Sclerosis
This is a prospective, non-randomised, non-blinded, single center study of children and adolescents with multiple sclerosis and clinically isolated syndrome to detect differences or early changes in diffusion-weighted imaging…
- Trial name
- NCT02361697
- Testing
- DTI-MRI
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Multiple Sclerosis, Performance Enhancement
Effects of DHA in Patients With Multiple Sclerosis
This clinical trial will investigate the effects of combining therapeutic exercise with DHA supplementation in 100 patients with multiple sclerosis using a randomized controlled design.
- Conditions
- Multiple Sclerosis, Performance Enhancement, Supplemental Nutrition Assistance Program Education, Strength Outcomes
- Trial name
- DHAME (NCT07346703)
- Testing
- Docosahexaenoic Acid (DHA) Dietary Supplement, Sunflower Oil
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
CIDP
Biomark Study: Predict Intravenous Immunoglobulin Responders in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
This study aims analyze the transcriptome to identify predictive biomarkers of IVIG in CIDP patients. 25 patients with a diagnosis of CIDP according to European criteria, naïve of treatment, will be included and followed for 1…
- Trial name
- BIOMARK (NCT02629796)
- Testing
- CIDP treated (IVIG)
- Where
- 18 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Multiple Sclerosis, Alzheimer Disease
Optical Coherence Tomography in Neurological Practice: Utility and Applicability Across Neurological Diseases (OCt.IN.N)
OCt.IN.N is a national, monocentric, prospective, observational cohort study evaluating the utility and applicability of Optical Coherence Tomography (OCT) in the diagnostic workup and longitudinal monitoring of neurological…
- Conditions
- Multiple Sclerosis, Alzheimer Disease, Parkinson Disease, Migraine
- Trial name
- OCT (NCT07720765)
- Testing
- Optical Coherence Tomography (OCT) - Heidelberg SPECTRALIS HRA+OCT
- Where
- Italy
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Application of Multiparametric Structural and Functional MRI in Unraveling the Substrates of Cognitive Impairment and Disability in Multiple Sclerosis
Multiple sclerosis (MS) is a disabling inflammatory demyelinating disease of the nervous system that predominantly affects white matter, because of its complicated pathogenesis, and overlapping clinical manifestations with other…
- Trial name
- MS MRI (NCT06653283)
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Zhuo Wang
Multiple Sclerosis, Relapsing-Remitting
A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers.
GSK2018682 is a potent and selective agonist for the sphingosine-1- phosphate receptor subtype 1 (S1P1) with the potential to be an effective treatment for multiple sclerosis (MS).
- Trial name
- P1A114919 (NCT01466322)
- Testing
- GSK2018682 CD2 Capsule; GSK2018682 CD3 non-micronised Tablet; GSK2018682 CD3 micronised Tablet; GSK2018682 CD3 non-micronised Tablet in fed state
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Parkinson Disease, Stroke
Smart Wearable Device (gaitQ): Walk Better Project
This study will be underpinned by the new MRC guidelines for developing a complex intervention with a participatory design methodology that uses evidence-based research and behaviour change models alongside COSMIN methodology for…
- Conditions
- Parkinson Disease, Stroke, Multiple Sclerosis, Osteoporosis
- Trial name
- NCT05913219
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Multiple Sclerosis
Cognitive-motor Interference in Persons With MS
Dual tasking such as walking while talking on the phone or while remembering a shopping list is very frequently required in everyday life.
- Trial name
- NCT04158063
- Testing
- Dual Task Training, Single Mobility Training
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Pharmacokinetics of DMF and the Effects of DMF on Exploratory Biomarkers
The purpose of this study is to explore whether DMF (Dimethyl Fumarate) or MMF (monomethyl fumarate) its main bioactive metabolite, is capable of entering the central nervous system in SPMS patients that are being treated with…
- Trial name
- NCT02683863
- Testing
- BG00012 (DMF) (Tecfidera®.)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Multiple Sclerosis Center of Northeastern New York
Chronic Inflammatory Demyelinating Polyneuropathy
Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating chronic progressive or relapsing neuropathy believed to be secondary to an autoimmune response against peripheral nerve antigens.5 We have…
- Trial name
- NCT01379833
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Multiple Sclerosis, Kinesiophobia
Evaluation of the Presence and Effects of Kinesiophobia in Multiple Sclerosis
The aim of this study was to evaluate the presence of kinesiophobia in multiple sclerosis and to investigate the effect of kinesiophobia on physical activity, functional status, quality of life and depression.
- Trial name
- NCT06167447
- Testing
- questionnaire and examination
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis
Early Symptoms in Multiple Sclerosis: an Investigation Using fMRI and Gait Analysis to Develop Personalized Balance Training for People With Low Disability
Background Many people with Multiple Sclerosis (MS) experience a hidden yet clinically significant symptom: impaired balance or a persistent feeling of instability, even during the early stages of the disease (Martin et al.…
- Trial name
- EMS_Rehab (NCT07805733)
- Testing
- Vestibular Physical Therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- LIFE - Research and Care Institute - Santa Lucia IRCCS
Fatigue, Functionality
The Effect of the Level of Hand Fatigability on Multiple Sclerosis on General Fatigue and Functionality
The objective of this study is to investigate the effect of the level of hand fatigability on general fatigue and functionality by comparing Relapsing-Remitting Multiple Sclerosis individuals with age and sex-matched healthy…
- Conditions
- Fatigue, Functionality, Multiple Sclerosis, Dexterity
- Trial name
- NCT05880745
- Testing
- Nine-Hole Peg Test (NHPT)
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pamukkale University