Clinical trials: Dental Anaesthesia
Dental Pain, Anesthesia, Local
A Split Mouth Trial to Compare Microneedles vs. Standard Needles in Dental Anaesthetic Delivery
The study will be completed as a two part, prospective, single-centre, randomised controlled trial. Five volunteers (dentists) will be recruited in the first part of the study to evaluate and examine the microneedle device and…
- Trial name
- NCT02966067
- Testing
- Microneedle Device (Experimental), 30-gauge Short Hypodermic Needle
- Where
- Ireland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Caries,Dental, Apical Periodontitis
Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric
The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine…
- Trial name
- NCT03962634
- Testing
- Kovanaze Nasal Spray, Articaine Injection
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Anxiety, Anesthesia, Local
Dental Anaesthesia Affects Pain Level
Background: Needles are the most feared tools, making anaesthetic injection a worrying practice. Aim: To compare intraosseous (IOA) and needle-free dental anaesthesia (NFA) methods that painless anaesthesia.
- Trial name
- NCT05002673
- Testing
- DENTAL LOCAL ANESTHESİA
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Behavior, Child, Anxiety, Dental
Virtual Reality in Pediatric Dentistry
Dental Fear and Anxiety is an emotional experiences affecting many children and adolescents which can lead to behavioral problems in the dental setting.
- Trial name
- NCT05585905
- Testing
- Virtual Reality, Basic Behavior Guidance Techniques
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Anesthesia, Dental
Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Mandibular Procedures
This Phase 3 study is designed as a multicenter, randomized, blinded, controlled study to evaluate the efficacy, pharmacodynamics, and safety of NV-101 administered as a submucosal injection following completion of a restorative…
- Trial name
- NCT00309361
- Testing
- Phentolamine Mesylate (NV-101)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Novalar Pharmaceuticals, Inc.
Dental Pain, Postoperative Pain
Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel
The project is a study comparing the effectiveness of two topical anesthetics for control of pain associated with dental needle insertion in the palatal mucosa.
- Trial name
- NCT00846690
- Testing
- benzocaine, TAC alternate gel
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Dental Anxiety, Pain
Comparison of Five Anesthetic Delivery Systems for Palatal Infiltration
This study is a randomized clinical trial evaluating five different anesthetic delivery systems for palatal infiltration in adults undergoing maxillary molar extraction.
- Conditions
- Dental Anxiety, Pain, Dental, Palatal Anesthesia
- Trial name
- PAL-INJECT (NCT07184879)
- Testing
- Conventional Dental Syringe, Spring-Activated Syringe (PCJ, PAROJECT™), Needle-Free Jet Injector (NFI, Comfort-in™)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sercan Küçükkurt
Anesthesia
Dose-Ranging Study of Intranasal Kovacaine Mist in Pediatric Subjects
The purpose of this study is to assess the efficacy and safety of intranasally administered Kovacaine Mist for anesthetizing maxillary teeth in pediatric subjects.
- Trial name
- NCT01701505
- Testing
- 400uL of Kovacaine Mist, 200uL of Kovacaine Mist, 120uL of Kovacaine Mist
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- St. Renatus, LLC
Pain
Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
The purpose of this study is to determine the effectiveness of buffered local anesthesia injections to numb the gums and teeth during dental treatment.
- Trial name
- BufferDent (NCT01622296)
- Testing
- Sodium bicarbonate, Lidocaine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dental Anesthesia Efficacy
Anesthetic Efficacy of Liposomal Prilocaine in Maxillary Infiltration Anesthesia
This blinded randomized, crossover, three period study aim to evaluate the anesthetic efficacy of liposome-encapsulated 3% prilocaine compared to 3% plain prilocaine and 3% prilocaine with 0,03IU/mL felypressin, after 1.8mL…
- Trial name
- NCT01073371
- Testing
- Prilocaine
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Post-operative Pain
Postoperative Pain in Children Aged From 3 to 5 Years Following Full Mouth Dental Rehabilitation Under General Anesthesia. A Cross-sectional Study. Rehabilitation Under General Anesthesia
the purpose of this study is monitoring Postoperative pain in Children Aged from 3 to 5 years following Full mouth Dental Rehabilitation under General Anesthesia
- Trial name
- NCT03739567
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Local Anesthesia Injection Pain
Clinical Evaluation of no Needle Dental Anesthesia Compared to Syringe Anesthesia Delivery
The purpose of the study is to evaluate two different ways to administer the numbing solution. One is with a conventional needle and syringe the other method iontophoresis is a machine that supplies a weak current through…
- Trial name
- NCT06874244
- Testing
- Local Anesthesia (lidocaine hydrochloride), Iontophoresis of Tetracaine and oxymetazoline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Anesthesia, Local, Needle Phobia
Needle-free Dental Anesthesia
Many patients experience pain and anxiety from traditional needle anesthesia and may avoid necessary dental treatments. The needle-free liquid jet injection(NFLJI) could solve these problems.
- Trial name
- NCT04493528
- Testing
- Meso-Jet, 2% lidocaine(xylocaine), Needle,2% lidocaine(xylocaine)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Anesthesia Intubation Complication
Nasotracheal Tube Stenting by Nelaton Catheter in Pediatric Dental Surgery
The value of this study is to compare between stented endotracheal tube with nelaton catheter and non stented tube as regard nasotracheal related complications as epistaxis and nasal cavity injury.
- Trial name
- NCT03462732
- Testing
- Endotracheal tube, Nelaton catheter
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Anesthesia
Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth
The purpose of this study is to compare the efficacy of Kovacaine Mist, Tetracaine only, and Placebo for inducing pulpal anesthesia of the maxillary teeth in adults.
- Trial name
- NCT01660893
- Testing
- Tetracaine HCl 3% and oxymetazoline HCl 0.05%, Tetracaine HCl 3%
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- St. Renatus, LLC
Anesthesia, Local
Evaluation of Buffered Local Anesthesia in Dental Extraction.
To compare pain during injection, onset of anesthesia and effectiveness of anesthesia using buffered versus non- buffered 2% lidocaine with 1:80,000 adrenaline in dental extraction.
- Trial name
- NCT04773236
- Testing
- sodium bicarbonate 8.4%, 2%lidocaine with 1:80.000 epinphrine, Mixing pen (onset buffering system)
- Volunteers
- 100 people
- Sponsor
- University of Baghdad
Pain
The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children
the porpose of study to assess The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children
- Trial name
- NCT07002528
- Testing
- sucrose solution, Cryotherapy, topical anesthesia
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Prosthesis Failure, Dental
Clinical Success of Anterior and Posterior Crowns in a Group of Children Treated Under General Anesthesia
This incidence study aims to evaluate the clinical success of anterior and posterior full-coverage restorations among a group of Egyptian children treated under general anesthesia.
- Trial name
- NCT06201481
- Testing
- anterior and posterior full coverage crowns
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Local Anesthesia, Pain, Postoperative
EMLA Topical Anesthetic During Scaling and Root Planing
Injectable anesthesics previous to subgingival scaling and root planing (SRP) presents some disadvantages like fear of the needle insertion, long-lasting effect and prolonged dampening of adjacent tissues.
- Conditions
- Local Anesthesia, Pain, Postoperative, Self-Perception
- Trial name
- NCT01860235
- Testing
- EMLA, Injectable anesthesia, 2% Benzocaine
- Volunteers
- 32 people
- Sponsor
- Franciscan University Center