Clinical trials: Dental Developmental Disorders and Anomalies
Dental Fluorosis
Clinical Evaluation of Dental Fluororsis Treatment Modalities
Background: Various treatment modalities are available to improve esthetics of fluorosed teeth based on its severity. Aim: evaluate the clinical performance of different minimal invasive treatment protocols on mild to moderate…
- Trial name
- NCT05204277
- Testing
- Opalescence™ boost™ PF 40%, Opalustre™, MI-Paste Plus®
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Molar-Incisor Hypomineralization (MIH)
Er:YAG Laser Versus Conventional Cavity Preparation in Children With Molar-Incisor Hypomineralization
This randomized clinical trial compares Er:YAG laser-assisted and conventional rotary cavity preparation in children aged 6-12 years with molar-incisor hypomineralization.
- Trial name
- NCT07759739
- Testing
- Er:YAG Laser-Assisted Cavity Preparation, Conventional Rotary Cavity Preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ege University
Molar Incisor Hypomineralization
Clinical Evaluation of Giomer and Resin-based Fissure Sealants
The objective of this research was to evaluate the clinical success of giomer and resin-based sealants applied in the first permanent molars (FPMs) affected by MIH.
- Trial name
- NCT04929782
- Testing
- Resin-based sealant, Giomer sealants
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Hacettepe University
Molar Incisor Hypomineralization
A Comparison of Two Different Management Techniques for Extensive Molar Defects in Patients Suffering From MIH
It is a randomized clinical trial in which two different types of full coverage restoration in used to restore hypomineralized first permanent molar and protect the remaining tooth structure in patients with molar incisor…
- Trial name
- NCT04209920
- Testing
- CAD-CAM milled PMMA crown, Cast metal coping using nickel chromium alloy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Molar Incisor Hypomineralization
Effectiveness of Pulpotomy in Carious First Permanent Molar
Pediatric dentists frequently encounter deeply carious young permanent first molars (PFM) with Molar Incisor Hypomineralisation (MIH).
- Trial name
- NCT06137391
- Testing
- Vital Pulp Therapy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Molar-Incisor Hypomineralization (MIH)
Direct Composite Versus Indirect Hybrid Resin Restorations in Hypomineralized First Permanent Molars
The aim of this clinical trial is to evaluate the clinical success of 3D printed Indirect hybrid resin restorations in the hypomineralized first permanent molars.
- Trial name
- NCT07718191
- Testing
- 3d printed restoration, composite
- Volunteers
- 40 people
- Sponsor
- Cairo University
Molar Incisor Hypomineralization
EVALUATION of PREVENTIVE EFFECT of SEALANTS and LASER THERAPY on DENTAL CARIES and POSTERUPTIVE BREAKDOWN on MOLARS AFFECTED with MOLAR INCISOR HYPOMINERALISATION (RANDOMIZED CLINICAL TRIAL)
Background: Molar Incisor Hypomineralisation (MIH) is a qualitative defect of enamel that shows asymmetrical involvement of one to four permanent first molars (PFM) with or without incisor teeth involvement.
- Trial name
- NCT06801561
- Testing
- Laser therapy, Glass ionomer sealant
- Where
- Egypt
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous Local Anesthesia System in Children With Molar Incisor Hypomineralization
The goal of this clinical trial is to compare in effectiveness of intraosseous anesthesia and inferior alveolar block anesthesia in children with molar incisor hypomineralization (MIH).
- Conditions
- Molar Incisor Hypomineralization, Hypersensitivity, Composite Restoration
- Trial name
- NCT06461143
- Testing
- %4 articaine with 1:200 000 adrenaline
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Molar Incisor Hypomineralization
Three Restorative Protocols in MIH: a Randomized Controlled Clinical Study
Molar-Incisive Hipomineralization (MIH) is defined as a qualitative change in tooth enamel of systemic origin, which affects one or more permanent first molars, and may or may not involve permanent incisors.
- Trial name
- NCT03760497
- Testing
- Restorative treatment
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Molar Hypomineralization, Incisor
Orofacial Functions in Individuals With and Without Molar Incisor Hypomineralization
Molar incisor hypomineralization (MIH) is a qualitative developmental defect of the enamel with a complex, multifactorial nature and a significant genetic component that predominantly affects the permanent first molars and…
- Trial name
- NCT06692257
- Testing
- Observation
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Molar Incisor Hypomineralisation
SleeperOne® 5 Intraosseous Anesthesia in MIH
This randomized split-mouth clinical trial evaluates whether computer-controlled intraosseous anesthesia delivered with the SleeperOne® 5 system reduces pain perception and dental anxiety compared with conventional local…
- Trial name
- CCLAD-MIH (NCT07741487)
- Testing
- SleeperOne® 5 Computer-Controlled Intraosseous Anesthesia, Conventional Local Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Ankara University
Osteogenesis Imperfecta
Clear Aligners for the Treatment of Dental Malocclusion in OI
Misalignment of teeth and jaws (also called malocclusion) is a common life altering problem facing many individuals with Osteogenesis Imperfecta (OI).
- Trial name
- NCT04815564
- Testing
- Invisalign
- Where
- 3 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- Baylor College of Medicine
Molar-Incisor Hypomineralization
Clinical Efficacies of Different Agents in Molar-Incisor Hypomineralization
This study aims to assess the clinical effectiveness of GC Fuji Triage ® (GC America Inc., Alsip, Illinois) and BeutiSealant (Shofu, Kyoto, Japan) in children aged 8-13 with multiple molars affected by Molar-Incisor…
- Trial name
- NCT06180369
- Testing
- GC Fuji Triage ® GC America Inc., Alsip, Illinois ), BeutiSealant (Shofu, Kyoto, Japonya)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Marmara University
Fluorosis, Dental, Non-Fluoride Enamel Opacities
Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth
The present study was designed as a randomised controlled clinical trial which was unicenter, double-blinded, parallel designed study, according to the Consolidated Standards of Reporting Trials (CONSORT) criteria, 2010.
- Conditions
- Fluorosis, Dental, Non-Fluoride Enamel Opacities, Dentin Sensitivity
- Trial name
- NCT03237793
- Testing
- Fluorosed Group, Non Flourosed Group
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Molar-Incisor Hypomineralization (MIH)
Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste
This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste.
- Trial name
- NCT07436039
- Testing
- Fluoridated Toothpaste, Nano-hydroxyapatite Toothpaste
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Abdulaziz University
Molar Incisor Hypomineralization
Molar Incisor Hypomineralization and Hypomineralized Second Primary Molars
Molar and Incisor Hypomineralization (MIH) is a qualitative developmental defect of the dental enamel with a multifactorial aetiology defined in 2001 as an "hypomineralization of systemic origin affecting one or more permanent…
- Trial name
- NCT05809791
- Where
- 5 sites in Italy, Spain and 1 more
- Volunteers
- 97 people
- Sponsor
- IRCCS Burlo Garofolo
Molar Incisor Hypomineralization
Clinical Evaluation of Direct Composite Veneer Restorations
The objective of this research was to evaluate the clinical success of direct composite veneer restorations performed in permanent incisors affected by molar-incisor hypomineralization.
- Trial name
- NCT05842590
- Testing
- Composite Veneer Restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Molar-Incisor Hypomineralization (MIH), Pulp Disease, Dental
Assessment of Inflammatory Biomarkers in Molar-Incisor Hypomineralization-Affected First Permanent Molars
Molar-Incisor Hypomineralization (MIH) is a qualitative developmental defect of enamel primarily affecting the permanent first molars and often incisors. The global prevalence of MIH ranges from 2.9% to 44%.
- Conditions
- Molar-Incisor Hypomineralization (MIH), Pulp Disease, Dental, Inflamation
- Trial name
- NCT07008599
- Testing
- Pulpal Blood Sample
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Marmara University
Dental Caries, Dental Fluoroses
Iowa Fluoride Study/Iowa Bone Development Study
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries.
- Conditions
- Dental Caries, Dental Fluoroses, Bone Density
- Trial name
- (IFS/IBDS) (NCT03547128)
- Volunteers
- 1,882 people, healthy volunteers welcome
- Sponsor
- Steven M Levy
Molar Hypomineralization, Incisor
Resin Infiltration vs Ionomer-Based Fluoride Varnish for the Prevention of Post-Eruptive Breakdown in Molars With Mild MIH
round/Objective: The objective of this clinical trial is to evaluate the clinical efficacy of a resin infiltrant (Icon®, DMG) compared to an ionomer-based fluoride varnish (Clinpro XT®, 3M) in preventing post-eruptive enamel…
- Trial name
- MIH (NCT07443878)
- Testing
- Resin Infiltrant (Icon®, DMG), Varnish-Modified Glass Ionomer (Clinpro XT®, 3M)
- Where
- Mexico
- Volunteers
- 17 people
- Sponsor
- Universidad Autonoma de San Luis Potosí