Clinical trials: Deprescribing
Inappropriate Prescribing, Primary Health Care
Deprescribing in Primary Health Care
Medications can help older adults but can also harm them. Frail older adults tend to have many health problems that require treatment, but are also at risk of harm from the medications prescribed.
- Conditions
- Inappropriate Prescribing, Primary Health Care, Polypharmacy
- Trial name
- NCT03903484
- Testing
- Deprescribing toolbox and intervention
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Benzodiazepine Dependence, Anxiety Disorders
Anxiety Lowering and Deprescribing Through Emotion Regulation
The goal of this clinical trial is to test ALDER (Anxiety Lowering and Deprescribing through Emotion Regulation), an online self-guided positive emotion intervention, in patients over the age of 65 who are candidates for…
- Conditions
- Benzodiazepine Dependence, Anxiety Disorders, Sleep Disturbance
- Trial name
- ALDER (NCT06359314)
- Testing
- ALDER
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Polypharmacy, Inappropriate Prescribing
Opportunities and Limits to Deprescribing in Nursing Homes:Quality Circle Deprescribing Module
Older people residing in nursing homes (NH) are frequently polymedicated and often prescribed potentially inappropriate medications.
- Trial name
- OLD-NH-QC-DeMo (NCT03688542)
- Testing
- Quality Circle Deprescribing Module
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Anne Niquille
Deprescribing
Leveraging Behavioral Science to Improve Medicine Optimization Conversations With Older Adults
Our online, survey-based experiment will include 2,400 adults who are 65-years and older (n=1,200 each from United States and Australia).
- Trial name
- NCT06698770
- Testing
- Anticipated long-term use of medication, Period re-evaluation of medication
- Where
- United States
- Volunteers
- 2,420 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anxiety, Insomnia
Augmenting Benzodiazepine Receptor Agonist Deprescribing With Acupuncture and Yoga Among Older Adults
The main purpose of this 12-week study is to see if a new combination of treatments can help older adults reduce benzodiazepine or related medication use.
- Conditions
- Anxiety, Insomnia, Benzodiazepine, Deprescription
- Trial name
- NCT06197243
- Testing
- Acupuncture, Yoga, Deprescribing
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Psychological
Developement and Validation of the Health Behavior Questionnaire Towards Deprescribing (HBQtD)
The goal of this observational study is to: 1. develop and validate a health behavior theory-based questionnaire to examine the older adults' and informal caregivers' determinants of deprescribing behavior 2.
- Trial name
- HBQtD (NCT06212713)
- Testing
- Questionnaire administration
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Polypharmacy, Deprescriptions
Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal
This study protocol comprises three phases. The first two phases will be nationwide and aim to evaluate the prevalence and patterns of polypharmacy and assess the barriers and facilitators of deprescribing perceived by older…
- Trial name
- DePil17-20 (NCT03283735)
- Testing
- Elderly Enablement
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Polypharmacy, Adverse Drug Reaction
Deprescribing of Symptomatic Medications in Rehabilitative or Subacute Care Patients
Deprescribing is a systematic method of withdrawing potentially inappropriate or unnecessary medications and is warranted in the elderly due to the high prevalence of polypharmacy.
- Trial name
- NCT03354845
- Testing
- Deprescribing intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bright Vision Hospital
Deprescribing, Multi-disciplinary
Efficacy and Feasibility of De-prescribing Rounds in a Singapore Rehabilitative Hospital- a Pilot Randomized Controlled Trial
This open-labelled randomized control trial will be conducted in a Singapore Rehabilitation Hospital to investigate the efficacy, cost-reduction, safety and feasibility of a weekly deprescribing multi-disciplinary inpatient…
- Conditions
- Deprescribing, Multi-disciplinary, Rounds
- Trial name
- NCT03713112
- Testing
- Weekly MDT deprescribing rounds for certain drugs
- Where
- Singapore
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Bright Vision Hospital
Dementia, Potentially Inappropriate Medication Use
e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational…
- Conditions
- Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
- Trial name
- e-ALIGN (NCT07454824)
- Testing
- e-ALIGN Patient-Portal Deprescribing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Aging, Adverse Drug Interaction
MinMed: Do Older Adults do Better With Less Medication
Many health care providers believe "less-is-more" for older adults, and evidence suggests minimizing certain medications might improve health outcomes.
- Conditions
- Aging, Adverse Drug Interaction, Frailty
- Trial name
- NCT05307666
- Testing
- Medication minimization
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Terminal Cancer
Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life
Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice.
- Trial name
- SERENITY (NCT05706740)
- Testing
- Physician survey on antithrombotic medication during end-of-life care in cancer patients
- Where
- 12 sites in Denmark, France and 6 more
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Polypharmacy, Dementia
Adapting the Shed-MEDS Deprescribing Intervention to Dementia Care in Assisted Living
This single-arm pilot study will evaluate the effects of an intervention to reduce exposure to unnecessary or potentially harmful medications among residents with dementia living in an assisted living facility.
- Conditions
- Polypharmacy, Dementia, Quality of Life
- Trial name
- NCT05956665
- Testing
- Shed-MEDS deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Polypharmacy, Deprescribing
Effect of Medication Management at Home Via Pharmacy Home Televisits
Older Veterans, particularly those with multiple chronic conditions requiring complex medication regimens, are more susceptible to adverse effects of medications.
- Conditions
- Polypharmacy, Deprescribing, Telemedicine
- Trial name
- NCT04340570
- Testing
- Medication management via televisit to home
- Where
- 2 sites in United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Polypharmacy, Dementia
Shared Decision Making About Medication Use for People With Multiple Health Problems
The Shared Decision Making about Medication Use for People with Multiple Health Problems study will assess the feasibility and acceptability of a deprescribing educational intervention in primary care for patients with mild…
- Conditions
- Polypharmacy, Dementia, Multiple Chronic Conditions, Deprescribing
- Trial name
- NCT05156073
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Fall, Fall Injury
Testing the SNOWDROP Intervention: Using a Clinical Decision Support System and Patient Portal for Falls Prevention Among Older Patients in Primary Care
Falls are a leading cause of injuries among older patients. Medication use is a major risk factor for falls. Because we lack tools to assess individualized risks, general practitioners (GPs) struggle with fall-related medication…
- Conditions
- Fall, Fall Injury, Fall Patients, Accidental Fall
- Trial name
- SNOWDROP (NCT05611008)
- Testing
- CDSS, Patient Portal
- Where
- Netherlands
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Amsterdam
Polypharmacy
Bundled Hyperpolypharmacy Deprescribing
Older patients using many prescription drugs (hyperpolypharmacy) may be at increased risk of adverse drug effects. This randomized controlled trial tested the effectiveness and safety of a quality intervention intended to reduce…
- Trial name
- NCT05616689
- Testing
- Bundled hyperpolypharmacy
- Where
- United States
- Volunteers
- 2,471 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Polypharmacy, Alzheimer Disease and Related Dementias
Aligning Medications With What Matters Most
The Aligning Medications with What Matters Most (ALIGN) study will assess the feasibility and preliminary efficacy of a deprescribing intervention to reduce medication regimen complexity and treatment burden for people living…
- Trial name
- ALIGN (NCT04938648)
- Testing
- Pharmacist-led deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Polypharmacy, Alzheimer's Disease and Related Dementias
ALIGN: Aligning Medications With What Matters Most (Demonstration)
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners.
- Conditions
- Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
- Trial name
- NCT06335953
- Testing
- Pharmacist-led deprescribing intervention
- Where
- United States
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Deprescription, Antidepressants
Deprescription of Antidepressants in Primary Care (DAPriCare)
Introduction The consumption of antidepressants has increased considerably worldwide, including in Spain. Despite their effectiveness in cases of moderate to severe depression, their long-term use in mild cases is questioned.
- Trial name
- DAPriCare (NCT06796946)
- Testing
- Deprescription of Antidepressants (fluoxetine, citalopram, sertraline, paroxetine, and escitalopram)
- Where
- Spain
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of Huelva