Clinical trials: Depressed Mood
Depressive Disorder, Depression - Major Depressive Disorder
A Qualitative Analysis of Youth Responses to Depression Education Delivered on Social Media
Depression is a common mental disorder among adolescents, with increased rates during the COVID-19 pandemic. Despite its high burden, few young people seek professional help due to, among other things, low mental health literacy…
- Conditions
- Depressive Disorder, Depression - Major Depressive Disorder, Depression in Adolescence
- Trial name
- NCT07100548
- Testing
- "ich bin alles" (English: "I am everything")
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Stress, Anxiety
Psychological Effects of a Set of Essential Oils
The goal of this clinical trial is to test the effectiveness of an intervention designed to improve wellness through aromatherapy.
- Conditions
- Stress, Anxiety, Well-Being, Psychological, Mood
- Trial name
- PSYFRAG (NCT06271759)
- Testing
- Fragrance inhalation
- Where
- Romania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bucharest
Maternal Distress
Essential Coaching for Every Mother, a Postpartum Text Message Program for Canadian Mothers
The purpose of this study is to evaluate a text message-based program called Essential Coaching for Every Mother which sends daily text messages during the immediate six-week postnatal period.
- Trial name
- ECEM (NCT04730570)
- Testing
- Essential Coaching for Every Mother
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Major Depressive Disorder (MDD)
Reward-specific Changes of the Chemical Messenger Dopamine in the Brain of Healthy and Depressed People
Major depressive disorder was shown to be associated with pathological alterations within neurotransmitter systems of the brain.
- Trial name
- NCT06675851
- Testing
- WELLBUTRIN SR (Bupropion HCI) Sustained-Release Tablets, 150 mg; GlaxoSmithKline, Cipralex (escitalopram)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Major Depressive Disorder, Anhedonia
Depression and Dopamine Transporter Function Study Using C-11 Altropane
Major depressive disorder (MDD) is often characterized by anhedonia and impaired ability to modulate behavior as a function of rewards.
- Trial name
- NCT01701141
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder
Effects of Early Abuse on Adult Intimate Relationships
This study is designed to help us better understand the factors that affect the sexual lives of women who have been sexually mistreated during childhood.
- Conditions
- Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder, Female Orgasmic Disorder, Major Depressive Disorder
- Trial name
- NCT01803802
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Treatment Resistant Depression, Visual Perceptual Weakness
Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression
Major depressive disorder (MDD) exhibit reduced visual motor perception, which affects prognosis. Metabolic substance changes and abnormal neural activity in the middle temporal visual area (MT) mediate this perceptual…
- Trial name
- NCT06044324
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depressive Symptoms
Dexamethasone and Ketamine on Change of Postoperative Mood
Ketamine and dexamethasone have been known to be effective postoperative pain. Many studies also have reported these two drugs might change mood such as depression.
- Trial name
- NCT03194594
- Testing
- Ketamine Hydrochloride, dexamethasone, and combination of two drugs
- Where
- South Korea
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Major Depression in Remission
Online Cognitive Control Training for Remitted Depressed Patients
This study evaluates the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
- Trial name
- NCT03278756
- Testing
- Cognitive control training, Active control training
- Where
- Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Ghent
Mood
Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers
5-hydroxytryptophan (5-HTP) is a nutritional supplement sold in many health food stores, and is taken in order to raise levels of serotonin in the brain. Serotonin is a neurotransmitter that is involved in the regulation of mood.
- Trial name
- NCT01514409
- Testing
- 5-Hydroxytryptophan, Pharmaceutical grade silica
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Bipolar Disorder, Major Depressive Disorder
The Gut Microbiota of Bipolar and Depression
Background: The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment.
- Trial name
- NCT03062332
- Testing
- Faecal genome
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Mood Disorders, Anxiety Disorders
Research on Anxiety and Depression: Computer-Assisted Therapy
This study examines how online self-guided programs can improve mood and anxiety symptoms. These programs use exercises from Cognitive-Behavioral Therapy, which is an evidence-based treatment for depression and anxiety.
- Trial name
- RADCAT (NCT02817438)
- Testing
- Good Days Ahead
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Stanford University
Postpartum Depression, Maternal Behavior
LoVE4MUM: Virtual Engagement for Preventing Postpartum Depression
Postpartum depression is a serious concern affecting mothers and their infants, especially with limited traditional support. This pilot study evaluates the effectiveness of a novel mobile app called LoVE4MUM, developed based on…
- Conditions
- Postpartum Depression, Maternal Behavior, mHealth Intervention, Mental Health Issue
- Trial name
- LoVE4MUM (NCT06366035)
- Testing
- LoVE4MUM mobile application
- Where
- 2 sites in Malaysia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health, Ministry of Health Malaysia
Depression
Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Site
This study will evaluate the effectiveness of interpersonal psychotherapy in treating pregnant women with depression.
- Trial name
- NCT00251043
- Testing
- Interpersonal psychotherapy for depression in pregnancy, Parenting education program (PEP)
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Major Depression
Blood Biomarkers in Suicidal Behaviour
Suicidal behavior (SB) is a major public health problem in France, with more than 10,000 suicides and 220,000 suicide attempts per year.
- Trial name
- 2BSB (NCT02855918)
- Testing
- Blood sample for genetic purpose
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Major Depression, Functional Dyspepsia
The Brain-Heart-Gut Connection
Major Depressive Disorder (MDD) often co-occurs with cardiovascular and gastrointestinal symptoms, highlighting the importance of the brain-heart-gut connection in developing comprehensive treatments.
- Conditions
- Major Depression, Functional Dyspepsia, Autonomous Dysfunction
- Trial name
- BHG-CONNECT (NCT06748274)
- Testing
- Transcranial Magnetic Stimulation (TMS), High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Bern
Schizophrenia, Bipolar Disorder
Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis
The purpose of this study is to better understand mental illness and will test the hypotheses that, while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after…
- Conditions
- Schizophrenia, Bipolar Disorder, Healthy, Psychosis
- Trial name
- GABAmech (NCT04004416)
- Testing
- Lorazepam and fMRI
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Major Depressive Disorder, Bipolar Disorder
Behavioral Processes Underlying Reward Processing in Depression
The purpose of this project is to use behavioral techniques to investigate emotional processing in subjects with major depression and healthy comparison subjects.
- Trial name
- NCT00205933
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Affective Neuroscience Laboratory
Postpartum Depression, Postpartum Anxiety
The Maternal Well-Being Study
This project aims to understand the local feasibility and acceptability of MamaMeals (a home-delivered nutritious, postpartum meal delivery program) and MamaMatters (a moderated social media-based peer support group) among…
- Conditions
- Postpartum Depression, Postpartum Anxiety, Weight Retention, Postpartum, Nutritional and Metabolic Diseases
- Trial name
- MWB (NCT05484999)
- Testing
- Meals, Meals + Social Support, Control
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Perinatal Mental Health, Reproductive Behavior
Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine
The goal of this observational study is to learn how war affects reproductive decisions and perinatal mental health in Ukrainian women.
- Conditions
- Perinatal Mental Health, Reproductive Behavior, Women, Cohort Studies
- Trial name
- NCT07551934
- Testing
- Psychological Assessment, Routine Clinical Data Collection
- Where
- Ukraine
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Taras Shevchenko National University of Kyiv
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