Clinical trials: Depression Disorder
Major Depressive Disorder
the Safety, Tolerability, and Pharmacokinetics Study of HEC113995
Multiple Dose Safety, Tolerability, PK and Food Effect Study of HEC113995 PA•H2O in Healthy Subjects
- Trial name
- NCT04623814
- Testing
- Food, HEC113995
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Major Depressive Disorder, Treatment Resistant Depression
The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression
Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and…
- Trial name
- NCT06163625
- Testing
- Repetitive Transcranial Magnetic Stimulation, Research Interview, Questionnaires, Brain Scan
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted
Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with mild cognitive impairment, or remitted major depressive disorder.
- Conditions
- Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted, Healthy Controls Group - Age and Sex-matched
- Trial name
- Creyos-MD (NCT06780917)
- Where
- 3 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Postpartum Depression
Study of Home-Based Exercise to Alleviate Postpartum Depression
The purpose of this study is to evaluate the effectiveness of an aerobic home-based exercise program for the treatment of postpartum depression.
- Trial name
- NCT00384943
- Testing
- Moderate-intensity Exercise
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- McGill University
Major Depressive Disorder
The Effect of Soluble Epoxide Hydrolase (SEH) on Depression
Depression is the most common mental disease and the second leading cause of chronic disease burden, which is closely related to suicidal behavior.
- Trial name
- NCT05575713
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Substance-Related Disorders, Depressive Disorder
Integrated Intervention for Substance Abusers With Depressive Disorders
This study is a randomized clinical trial comparing outcomes of Integrated Cognitive Behavioral Treatment plus standard medications for veterans with both substance use disorders, depressive disorders versus the most commonly…
- Trial name
- NCT00018655
- Testing
- Twelve Step Facilitation, Integrated Cognitive Behavioral Treatment
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Bipolar Disorder, Bipolar Depression
Uridine Adolescent Bipolar Depression Randomized Controlled Trial
This is a randomized, double-blind, placebo-controlled study of the investigational drug uridine as a treatment for depressed adolescents with bipolar disorder (i.e. "bipolar depression").
- Conditions
- Bipolar Disorder, Bipolar Depression, Manic Depression
- Trial name
- NCT01805440
- Testing
- Uridine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cognition, Affect (Mental Function)
PRECOG Pilot Project
This pilot study aims to investigate the chronic effects of a prebiotic blend on cognitive, affective and gut microbiome outcomes in healthy adults aged 60-75 years.
- Conditions
- Cognition, Affect (Mental Function), Gut Microbiome
- Trial name
- NCT06911957
- Testing
- Prebiotic blend
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Reading
Anxiety, Depression
Project THINK: Trial of a Brief Cognitive Restructuring Intervention
This project will involve testing a brief (~30 minute) digital intervention aimed at teaching youth the evidence-based strategy of changing unhelpful thoughts (i.e., cognitive restructuring).
- Conditions
- Anxiety, Depression, Stress
- Trial name
- NCT05720741
- Testing
- Project THINK, Project SHARE
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Harvard University
Depression Symptoms, Anxiety Symptoms
Developing a Booster Session for Problem Management Plus in the Bahamas: A Pilot Randomized Controlled Trial
Therapists at the Grand Bahama Resilience Center (GBRC) will be trained to deliver Problem Management Plus (PM+), a WHO intervention.
- Trial name
- NCT07208851
- Testing
- Problem Management Plus booster session
- Where
- The Bahamas
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The New School
Depression, Depression, Postpartum
Clinician Managed Interpersonal Psychotherapy
This 12-week study will evaluate the effectiveness of Clinician-Managed Interpersonal Psychotherapy (CM-IPT) in treating postpartum depression and will compare CM-IPT to standard IPT.
- Trial name
- NCT00043602
- Testing
- Standard interpersonal psychotherapy (IPT), Clinician managed interpersonal psychotherapy (CM-IPT)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Major Depressive Disorder
The Biological Specificity of Acupoints Between Major Depressive Disorder Patients and Healthy Controls
Evidence-based medicine suggests that acupuncture can improve major depressive disorder (MDD). However, the prevalent reliance on experiential acupoint selection lacks scientific underpinning.
- Trial name
- NCT06114342
- Where
- China
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Xiaomei Shao
Anxiety, Depression
Exercise to Prevent Depression and Anxiety in Older Hispanics
The study is a randomized pilot trial of a health promotion intervention in the prevention of anxiety and depression in older Hispanics.
- Trial name
- NCT02371954
- Testing
- Happy Older Latinos are Active, Fotonovela
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Miami
Temporomandibular Disorder, Temporomandibular Joint Dysfunction
Trauma Exposure and Childhood Trauma in Temporomandibular Joint Disorders
Temporomandibular disorder is a multifactorial condition that involves the temporomandibular joint, masticatory muscles, and surrounding structures and is influenced by biological, psychological, and social factors.
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Dysfunction, Trauma Exposure, Childhood Traumas
- Trial name
- NCT07292103
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Anxiety, Anxiety Disorders
A Single-session Growth Mindset Intervention for Children and Young People With Mental Health Difficulties
The present study aims to evaluate whether an online, self-administered, single session intervention (SSI) increases children and adolescents' perceptions of control over external threats and their emotional experience and…
- Conditions
- Anxiety, Anxiety Disorders, Depression, Low Mood
- Trial name
- NCT04652362
- Testing
- Growth Mindset Online Single-Session Intervention, Supportive Therapy Online Single-Session Intervention (Control)
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal Holloway University
Major Depressive Disorder, Bipolar Disorder
Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders
Evidence suggests that mGLUR5 availability may play a key role in the biology of mood disorders. This study aimed to investigate the changes in metabotropic glutamate receptor 5 (mGLUR5) availability and clinical symptoms in…
- Trial name
- NCT05840861
- Testing
- Vortioxetine, Quetiapine
- Where
- China
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Central South University
Postpartum Depression
Effect of Laughter Yoga Therapy on Postpartum Depression
Laughter yoga sessions, stretches and stretches, songs, clapping and body It starts with light warm-up techniques that include movements.
- Trial name
- NCT05133583
- Testing
- Laughter yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Adiyaman University Research Hospital
Depression
Emotional and Cognitive Control in Late-Onset Depression
This study may help identify how abnormalities in brain systems that control the ability to ignore irrelevant information may contribute to the development of depression in older adults.
- Trial name
- NCT01728194
- Testing
- Escitalopram, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder, Mood Disorders
Psychobiological Markers to Improve Diagnosis and to Predict Affective Episodes in Bipolar Disorder
This trial has two studies. In study 1, the investigators will explore the relationships between three psychobiological factors (sleep patterns, motor activity, and decision-making ability).
- Conditions
- Major Depressive Disorder, Mood Disorders, Bipolar Disorder (BD)
- Trial name
- MoodCatcher (NCT07427966)
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
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