Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depression, Depressive Symptoms
Predict Antidepressant Responsiveness Using Pharmacogenomics
The purpose of this study is to determine whether genetic information associated with individual depressive symptoms.
- Trial name
- NCT01228357
- Testing
- SSRI treated group, non-SSRI treated group
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Adolescent Development
PPI to Promote the Psychological Well-being of Children Living in Poverty
Positive psychology interventions use positive psychology techniques to identify meaning and value in life events to raise positive feelings and emotions.
- Trial name
- NCT04875507
- Testing
- Positive Psychology
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression
N-acetylcysteine in the Treatment of Depressive Symptoms in Bipolar Offspring
N-acetylcysteine in the treatment of depressive symptoms in youth at high-risk for bipolar disorder: a functional connectivity study
- Trial name
- NCT02865629
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Cincinnati
Perinatal Depression, Postpartum Depression
Development, Feasibility and Acceptability of Fathers and Babies (FAB): A Pilot Study
During this project the investigators will develop and pilot test a companion intervention for fathers (Fathers and Babies-FAB), to supplement the Mothers and Babies Course (MB) that provides stress and mood management tools for…
- Conditions
- Perinatal Depression, Postpartum Depression, Depression
- Trial name
- NCT03427528
- Testing
- Fathers and Babies (FAB), MB 1-on-1 plus TXT
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Major Depressive Disorder
IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)
This study tests the efficacy of interpersonal psychotherapy (IPT) for major depression following perinatal loss (early and late fetal death and early neonatal death) in a sample of 274 women in Flint and Detroit, Michigan.
- Trial name
- HeAL (NCT04629599)
- Testing
- Interpersonal psychotherapy for major depression following perinatal loss, Coping with Depression
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Michigan State University
Major Depressive Disorder
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Levomilnacipran ER fixed doses versus placebo in the treatment of outpatients with major depressive disorder.
- Trial name
- NCT00969709
- Testing
- Levomilnacipran ER
- Where
- 38 sites in United States
- Volunteers
- 724 people
- Sponsor
- Forest Laboratories
Premenstrual Dysphoric Disorder ( PMDD)
YAZ Premenstrual Dysphoric Disorder (PMDD) in China
The purpose of this study is to evaluate the efficacy and safety of YAZ compared to placebo in the treatment of symptoms related to Premenstrual Dysphoric Disorder (PMDD).
- Trial name
- NCT00824187
- Testing
- EE20/DRSP(YAZ, BAY86-5300)
- Where
- 16 sites in China
- Volunteers
- 187 people
- Sponsor
- Bayer
Depression, Major Depressive Disorder
Noninvasive Physiologic Sensors to Assess Depression
This project aims to use sensors to monitor physiological signals, sleep patterns, vocal characteristics, activity, location and phone usage in study patients with depression who are receiving standard treatment (compared with…
- Trial name
- NCT02568865
- Testing
- Physiological Sensors, Sleep Monitoring Device, Vocal Monitoring
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive Disorder
This study will investigate the effectivenss of bright light therapy(10000 lux white)on pregnant women with major depression disorder.
- Trial name
- GZPHBLT (NCT04447430)
- Testing
- bright light, dim red light
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Guangzhou Psychiatric Hospital
Treatment Resistant Depression, Depression
Glutamate Emotion Memory Study
Clinical depression often includes a pessimistic view of things which have happened in the past and an impairment in the ability to experience pleasure or looking forward to things.
- Conditions
- Treatment Resistant Depression, Depression, Major Depressive Disorder
- Trial name
- GEMS (NCT05809609)
- Testing
- Ketamine Hydrochloride
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Depressive Symptoms
Mindfulness-Based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) for Depression in Diabetes Patients
The purpose of this study is to determine whether mindfulness-based cognitive therapy (MBCT)and cognitive behavioral therapy (CBT)are effective in reducing depressive symptoms in patients with diabetes.
- Trial name
- NCT01630512
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Cognitive Behavioral Therapy (CBT)
- Where
- Netherlands
- Volunteers
- 94 people
- Sponsor
- University Medical Center Groningen
Depression
Computer-based Treatment of Dysfunctional Beliefs in Depressive Inpatients
The aim of the present study is to investigate whether confronting depressive patients with their dysfunctional core beliefs via a computer program results in a reduction of the patients' dysfunctional beliefs.
- Trial name
- NCT03389464
- Testing
- computer-based confrontation with dysfunctional beliefs
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Regensburg
Resistant Depression, Treatment
TReAtment With CombinedExercise in Patients With Resistant Major Depression
Major depressive disorder is one of the most prevalent and disabling mental disorders worldwide. Forty percent of people with major depressive disorder are in moderate remission, with the remainder meeting the criteria for…
- Trial name
- TRACE-RMD (NCT05136027)
- Testing
- Combined training
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- University of the Basque Country (UPV/EHU)
Suicide
Impairment of the Cognitive Flow in the Development of a Depressive Disorder and Suicidal Ideas
The study consists in estimating the mental load (cognitive saturation) and the production of driving cognition to suicidal patients.
- Trial name
- AQUARIUM (NCT03674580)
- Testing
- Follow-up of the suicidal patients
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Hôpital NOVO
Depressive Symptoms, Psychological Distress
Internet-based Intervention for Enhancing the Psychological Well-being of Elderly Caregivers
This study will examine whether an Internet-based Acceptance and Commitment Therapy (ACT) intervention is effective, firstly, on reducing depressive symptoms, and, secondly, on improving well-being of elderly family caregivers.
- Conditions
- Depressive Symptoms, Psychological Distress, Quality of Life
- Trial name
- CareACT (NCT03391596)
- Testing
- Internet-based ACT intervention, Standardized rehabilitation, Support by voluntary caregiver associations
- Where
- Finland
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- The Gerocenter Foundation for Research and Development
Folate Deficiency, Vitamin B 12 Deficiency
Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls
Folic acid and vitamin B12 play an interdependent role in key cellular processes, namely deoxyribonucleic acid synthesis, cell division, red blood cell formation, and nervous system myelination.
- Conditions
- Folate Deficiency, Vitamin B 12 Deficiency, Anemia, Megaloblastic, Cognitive Development
- Trial name
- NCT06100146
- Testing
- Folic acid and vitamin B12 fortified flour, Unfortified cereal flour
- Where
- 2 sites in Ethiopia
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- University Ghent
Bipolar Disorder, Depressive Disorder
Acute Effectiveness of Additional Drugs to the Standard Treatment of Depression
This study will compare the effectiveness of relatively new antidepressants which have different mechanisms of action. Buproprion (Wellbutrin) works on dopamine and the dopaminergic pathway.
- Trial name
- NCT00001483
- Testing
- buproprion (Wellbutrin), sertraline (Zoloft), venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Dysthymic Disorder
Duloxetine Treatment in Elderly With Dysthymia
Dysthymic disorder (DD) denotes chronic depression with fewer symptoms than major depressive disorder (MDD), and it affects ~ 2-4 % of adults with a similar prevalence in the elderly.
- Trial name
- NCT01852383
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Depression
Telehealth Depression Treatments for Older Adults
This study aims to find an effective and sustainable approach to reducing disparities in accessing mental health services for an underserved and growing population group of low-income, racially diverse, homebound older adults.
- Trial name
- NCT02600754
- Testing
- IT-PST, IT-SCM
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- University of Texas at Austin
Major Depressive Disorder
Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the safety and efficacy of an 8-week double-masked treatment of tasimelteon or placebo in male and female subjects with Major Depressive Disorder.
- Trial name
- MAGELLAN (NCT01428661)
- Testing
- tasimelteon
- Where
- 40 sites in United States
- Volunteers
- 507 people
- Sponsor
- Vanda Pharmaceuticals
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