Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Depressive Disorder, Major, Diabetic Neuropathies
Study Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathway
To evaluate the effects of multiple oral doses of desvenlafaxine sustained release (DVS SR) and paroxetine on the biotransformation of codeine to morphine in healthy subjects.
- Conditions
- Depressive Disorder, Major, Diabetic Neuropathies, Fibromyalgia, Vasomotor Symptoms
- Trial name
- NCT00456898
- Testing
- desvenlafaxine sustained release (DVS SR), Paroxetine, Codeine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depressive Disorder, Anxiety
An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress
The purpose of this study is to evaluate the efficacy and safety and tolerability of JNJ-42165279 in participants with major depressive disorder (MDD) with anxiety symptoms who have had inadequate response to treatment with a…
- Trial name
- NCT02498392
- Testing
- JNJ-42165279
- Where
- 32 sites in United States, Moldova and 4 more
- Volunteers
- 161 people
- Sponsor
- Janssen Research & Development, LLC
Postpartum Depression (PPD)
A Mobile Application for Early Detection and Symptoms Trajectories of Postpartum Depression Using Ecological Momentary Assessment (EMA)
This pilot study will recruit 120 perinatal pregnant women and follow them up for 6 months. Both momentary and retrospective assessments of emotional well-being and psychosocial factors will be conducted on a mobile application.
- Trial name
- EMA For PND (NCT07382336)
- Testing
- Ecological momentary assessment and retrospective assessment
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Postmenopause
Effects of Breathing Training on Psychosocial Functioning and Heart Rate Variability in Postmenopausal Women With Depressive Symptoms
The specific aims of this study are: 1. To develop a breathing training protocol specifically designed to improve HRV and psychosocial functioning for postmenopausal women with depressive symptoms, 2.
- Trial name
- NCT01044563
- Testing
- Breathing training, Stress management
- Where
- Taiwan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- National Science and Technology Council, Taiwan
Depression, Depressive Disorder, Major
Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions.
- Conditions
- Depression, Depressive Disorder, Major, Depression in Remission
- Trial name
- NCT05111665
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Relaxation Group Therapy (RGT), Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Multiple Sclerosis, Major Depressive Disorder
Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis
The goal of this single-arm, observational pilot study is to learn about the safety, feasibility, preliminary efficacy of TMS for the treatment of depression in people with MS.
- Conditions
- Multiple Sclerosis, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- NCT06329414
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Major Depression
A Study to Evaluate SAGE-217 in Participants With Moderate to Severe Major Depressive Disorder
This is a two-part (open-label followed by double-blind) study evaluating the safety, tolerability, pharmacokinetics, and efficacy of SAGE-217 in 102 participants diagnosed with moderate to severe Major Depressive Disorder.
- Trial name
- NCT03000530
- Testing
- SAGE-217
- Where
- 8 sites in United States
- Volunteers
- 102 people
- Sponsor
- Biogen
Major Depressive Disorders
Loneliness and Occurrence of Suicide Attempts and Suicidal Ideas
Suicide is a major health problem that causes annually a million death worldwide. Loneliness is known to be associated with suicidal ideation in minors and to be related with suicidal risk in elderly people.
- Trial name
- SOLSTIS (NCT02829671)
- Testing
- Clinical and biological assessment
- Volunteers
- 600 people
- Sponsor
- University Hospital, Montpellier
Major Depression
Brain Imaging of Quetiapine Response in Anxious Depression
The purpose of this study is to find out what parts of the brain have increased or decreased connectivity when people are depressed and how Seroquel extended release (XR) changes this connectivity in depressed patients.
- Trial name
- NCT00982345
- Testing
- quetiapine (Seroquel XR)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Major Depressive Disorder, Suicidal Ideation
MicroRNA Correlates of Childhood Maltreatment and Suicidality
This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g.
- Trial name
- NCT04923685
- Testing
- Trier Social Stress Test
- Where
- 2 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Molecular Mechanisms of Pharmacological Action, Depression
Effects of Seven Day Prucalopride Administration in Healthy Volunteers
This study will investigate whether seven days administration of the serotonin receptor subtype 4 (5-HT4) partial agonist prucalopride has effects on emotional processing and neural activity in healthy volunteers, compared to…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mood Disorders
- Trial name
- NCT03572790
- Testing
- Prucalopride
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Depression
Nexalin Therapy for the Treatment of Depressive Symptoms
The primary objectives of this Phase II study are to demonstrate the safety of Nexalin Therapy and to investigate the efficacy of Nexalin Therapy.
- Trial name
- NCT00774813
- Testing
- Nexalin 1.3mA Device, Nexalin 15mA device
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Kalaco Scientific, Inc.
Depressive Disorder, Major
Open-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Talk Program
The purpose of this study is to evaluate the effect of the Dialogues Time to Talk program in subjects treated with Venlafaxine Extended Release (ER).
- Trial name
- NCT00401726
- Testing
- Venlafaxine ER, Dialogues Time to Talk Program
- Where
- 44 sites in United States
- Volunteers
- 537 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Disorder (MDD)
Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression
This prospective observational study aims to evaluate changes in psychological defense mechanisms in patients with non-psychotic major depressive disorder (MDD) undergoing repetitive Transcranial Magnetic Stimulation (rTMS)…
- Trial name
- NCT07853989
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namik Kemal University
Mild Depression
Using a Smartphone App to Reduce Cognitive Vulnerability and Mild Depressive Symptoms
Depression is one of the major challenges worldwide, with significant increasing personal, economic, and societal costs. Although empirically supported treatments have been developed, they are not always available for patients in…
- Trial name
- NCT02783118
- Testing
- Self administered online CBT
- Where
- Romania
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Major Depressive Disorder
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to explore the neurobiological…
- Trial name
- NCT06211140
- Testing
- tACS, Control
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Emotional Problem, Anxiety
A Transdiagnostic Internet Intervention for Parents of Children With Anxiety and Depressive Symptoms
The purpose of this study is to evaluate the efficacy of a transdiagnostic, parent-led, Internet-delivered intervention in reducing child and adolescent internalizing problems.
- Conditions
- Emotional Problem, Anxiety, Depression, Psychological Distress
- Trial name
- ParentKIT (NCT05341297)
- Testing
- ParentKIT
- Where
- Romania
- Volunteers
- 111 people
- Sponsor
- Babes-Bolyai University
Major Depressive Disorder, Depression
Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents
This study will examine if brain insulin resistance is a feature of depression in humans using magnetic resonance imaging (MRI) measures sensitive to brain insulin action.
- Trial name
- NCT05571878
- Testing
- Humalog, Saline nasal spray
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Depression and Suicide
Accelerated Intermittent Theta Burst Stimulation for Depressive Symptoms
This study evaluates an accelerated schedule of theta-burst stimulation for depressive symptoms in psychiatric inpatients. A small pilot study (n=22) will be carried out to demonstrate feasibility, using the FDA-approved…
- Trial name
- aTBS (NCT03601117)
- Testing
- Dorsolateral Prefrontal Cortex Accelerated Theta Burst Stimulation, Anterior Cingulate Cortex Accelerated Theta Burst Stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Depressive Symptoms, Aging
Digital Gaming Intervention for Older People in Long-term Care
Older people in long-term care (LTC) are often less physically active than their community-dwelling peers. Low physical activity level is associated with more symptoms of anxiety and depression as well as with lower physical…
- Conditions
- Depressive Symptoms, Aging, Loneliness, Sedentary Behavior
- Trial name
- NCT06018974
- Testing
- Yetitablet gaming
- Where
- Finland
- Volunteers
- 49 people
- Sponsor
- University of Oulu
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