Clinical trials: Depressive, Symptoms Depressive Disorder, Depression
Diaper Dermatitis, Urinary Tract Infections
Intervention to Reduce Diaper Need and Increase Use of Pediatric Preventive Care
Well-child care is the primary source of preventative health care for children. These visits provide an opportunity for physicians to assess an infant's biomedical health, development, and behavior, as well as help ensure timely…
- Conditions
- Diaper Dermatitis, Urinary Tract Infections, Infection, Depressive Symptoms
- Trial name
- NCT03490045
- Testing
- Diaper Incentive, Conditional Cash Transfer Condition
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Yale University
Depressive Disorder, Depressive Disorder, Major
Synaptic Imaging and Network Activity in Treatment Resistant Depression
The main aim of this research is to explore the effects that ketamine has on the functional connectivity of the brain in participants with treatment resistant depression (TRD).
- Conditions
- Depressive Disorder, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Bipolar Disorder
- Trial name
- SIGNATURE (NCT05870501)
- Testing
- Ketamine, Midazolam
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- King's College London
Caregiver Burden, Depressive Symptoms
Cluster RCT of Cognitive Behavioral Therapy to Support Caregivers of Older Adults in Hong Kong
The goal of this cluster randomized controlled trial study is to compare the effectiveness of a novel psychosocial intervention based on Cognitive Behavioral Therapy, lifestyle intervention and effective communication skills in…
- Conditions
- Caregiver Burden, Depressive Symptoms, Quality of Life, Self Efficacy
- Trial name
- NCT06473012
- Testing
- Cognitive Behavioral Therapy for Caregivers of Older Adults, Control intervention for Caregivers of Older Adults
- Where
- Hong Kong
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Labor Pain, Pregnancy Outcomes
The Association Between Epidural Labor Analgesia and Pregnancy Outcomes
Labor analgesia can alleviate intrapartum pain, in the importance of the delivery is very obvious.But some researches think labor analgesia may affect the progress of labor, increase the cesarean section rate.This research adopts…
- Conditions
- Labor Pain, Pregnancy Outcomes, Psychological Disorder
- Trial name
- NCT03381495
- Testing
- Ropivacaine Hydrochloride, Sufentanil
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Deng Dongrui
Depression, Anxiety
Depressive and Anxiety Disorders in Patients With Chronic Liver Diseases
The aim of this observational study is to learn about the prevalence of depressive and anxiety disorders among patients with chronic liver diseases
- Trial name
- NCT06113029
- Testing
- The Hamilton Rating Scale for Anxiety, The Beck Depression inventory, Rand SF-36 Questionnaire
- Where
- Egypt
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Depression
Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial
This protocol describes a feasibility trial that will evaluate the feasibility of conducting a full-scale phase 3 trial testing the hypothesis that a postoperative sustained, low-dose ketamine infusion can prevent postoperative…
- Trial name
- K-PASS (NCT05233566)
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Washington University School of Medicine
Depression, Selective Serotonin Reuptake Inhibitor
Impact of Depression on Thermoregulation
The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with…
- Trial name
- NCT06805851
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Penn State University
Depressive Disorder, Major, Depression
Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms
Depression is a leading cause of disability worldwide, affecting roughly 21 million adults. Repetitive Negative Thought (RNT) has been identified as a potential maintaining factor in depression, such that those who exhibit higher…
- Trial name
- DMNtFUS (NCT06320028)
- Testing
- Non-Invasive Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Depression
Deep Brain Stimulation for Treatment-Refractory Major Depression
This study will investigate the use of deep brain stimulation (DBS) to reduce symptom severity and enhance the quality of life for patients with treatment-refractory major depression.
- Trial name
- NCT00122031
- Testing
- Deep Brain Stimulation with Medtronic Activa Neurostimulator
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- University Hospital, Bonn
Depressive Disorder
Validity of the 3-item Patient Health Questionnaire (PHQ-3) for Identifying Moderate-to-Severe Depressive Symptoms Among Elderly Perioperative Patients: A Secondary Analysis of a National Prospective Cohort
This is a retrospective observational study based on our hospital's prospective peri-operative elderly patient database. We aim to evaluate the correlation between the 9-item Patient Health Questionnaire (PHQ-9) and the brief…
- Trial name
- NCT07818057
- Testing
- Retrospective data analysis
- Where
- China
- Volunteers
- 10,536 people
- Sponsor
- Chinese PLA General Hospital
Major Depressive Disorder, Major Depression
Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group
Our goal is to study pharmacogenetics in Mexican-Americans, using depression treatments as a proof of the concept that pharmacogenetic approaches can be used to optimize treatment strategies for common and complex disorders in…
- Conditions
- Major Depressive Disorder, Major Depression, Unipolar Depression
- Trial name
- NCT00265291
- Testing
- fluoxetine or desipramine
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Depression, Bipolar, Depression, Unipolar
Pramipexole to Target "Anhedonic Depression"
The heterogeneity of depression suggests that different neurocircuits and pathophysiological mechanisms are involved. Anhedonia - the inability to experience pleasure from, or the lack of motivation to carry out, usually…
- Conditions
- Depression, Bipolar, Depression, Unipolar, Dysthymia, Anhedonia
- Trial name
- PILOT-PRAXOL (NCT04121091)
- Testing
- Pramipexole Pill
- Where
- Sweden
- Volunteers
- 13 people
- Sponsor
- Region Skane
Prenatal Anxiety, Prenatal Depression
Effectiveness of an Online Biopsychosocial Intervention to Improve Well-being and Mental Health During Pregnancy
This study aims to develop and implement a preventive intervention through a mobile application to help pregnant women feel better emotionally and cope with the changes of pregnancy in a more positive way.
- Conditions
- Prenatal Anxiety, Prenatal Depression, Wellbeing, Obstetrical Complications
- Trial name
- BienGestar (NCT06871397)
- Testing
- Biopsychosocial Cognitive Behavioral Intervention
- Where
- Spain
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
HEART DISEASE, Liver Failure
Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic
Alcohol abuse is associated with a variety of clinical diseases, but studies on prevalence of different somatic diseases among alcohol abusers are lacking. Studies on populations in an out-day patients' clinic are also lacking.
- Conditions
- HEART DISEASE, Liver Failure, DEPRESSIVE DISORDER, Alcoholic Neuropathy
- Trial name
- NCT01081197
- Testing
- Psychiatric and somatic examinations and ,if clinical indicated, treatment
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Helse Nord-Trøndelag HF
Depression - Major Depressive Disorder, Transcranial Magnetic Stimulation
Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Acid and Brain-derived Neurotrophic Factor Levels
The goal of this randomised clinical trial is to evaluate the effects of transcranial magnetic stimulation (TMS) on major depressive disorder (MDD) and on the levels of 5-hydroxyindoleacetic acid (5-HIAA) and brain-derived…
- Conditions
- Depression - Major Depressive Disorder, Transcranial Magnetic Stimulation, Placebo
- Trial name
- NCT06667180
- Testing
- Low-intensity TMS
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad de Guanajuato
Premenstrual Dysphoric Disorder
Targeting Inter-Hemispheric Alpha Coherence With tACS To Treat PMDD
Purpose: Using transcranial alternating current stimulation (tACS), we will study whether tACS induces changes in prefrontal alpha oscillatory frequencies in women with premenstrual dysphoric disorder (PMDD) and whether tACS…
- Trial name
- NCT02362191
- Testing
- Alternating Current Stimulator
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder (MDD), Depression in Adults
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD.
- Conditions
- Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders
- Trial name
- EMBRACE (NCT06793397)
- Testing
- CYB003, Psychological Support
- Where
- 79 sites in United States, Australia and 6 more
- Volunteers
- 330 people
- Sponsor
- Cybin IRL Limited
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
Treatment Resistant Depression (TRD)
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individuals with treatment-resistant…
- Trial name
- NCT07563868
- Testing
- Psychedelic Integration Coaching
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder, Therapy Resistant Depression
Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine Spray
Pragmatic clinical trial of an add-on therapy regarding the use of edupression.com® - a licensed computer based self-help program - on patients with therapy-resistant depression receiving esketamine nasal spray
- Trial name
- Esketamin+ (NCT04843462)
- Testing
- edupression.com®, Esketamine nasal spray
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Lukas Pezawas