Clinical trials: Depressive Disorders
Major Depressive Disorder, Bipolar I Disorder
Digital Phenotypes for Predicting Depression_Validation
This 12-month, single-site prospective observational study will prospectively monitor the recurrence of mood episodes while continuously collecting passive digital phenotypes in individuals with and without mood disorders.
- Conditions
- Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Mood Disorders
- Trial name
- NCT07880015
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Depression
Interference With Cognitive Control by Transcranial Direct Current Stimulation
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit.
- Trial name
- NCT01903538
- Testing
- Cathodal transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Psychological Distress, Impaired Social Functioning
A Scalable Psychological Intervention for Earthquake Survivors in Türkiye
This will be the first pilot randomized controlled trial (RCT) study that investigate the potential effectiveness of individual PM+ among earthquake survivors residing in container cities in Türkiye.
- Conditions
- Psychological Distress, Impaired Social Functioning, Depressive Symptoms
- Trial name
- NCT06026306
- Testing
- Problem Management Plus (PM+)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Koç University
Depression, Child Development
Improving Preterm Outcomes by Safeguarding Maternal Mental Health
The investigators' goal is to optimize the developmental outcomes of preterm infants by preventing depression and improving functioning among their mothers during the critical first year of life.
- Trial name
- NCT01892982
- Testing
- Problem Solving Education tailored to NICU
- Where
- 4 sites in United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Depressive Disorder, Major, Positron-Emission Tomography
Molecular Imaging of Brain Inflammation in Depressive Disorders
In a number of neuropsychiatric disorders such as depression, both brain inflammation and glutamate mediated excitotoxicity (cell death through over-activated stimulation) are suspected to play a key role.
- Trial name
- DiME (NCT02983318)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Aging, Dementia Alzheimers
Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)
Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation.
- Conditions
- Aging, Dementia Alzheimers, Parkinson Disease, Dementia Frontotemporal
- Trial name
- NCT05967390
- Testing
- Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Mental Disorder, Depression Disorders
The Effect of Acceptance and Commitment Therapy-Based Intervention
Mental health is essential for students' emotional, cognitive, and social well-being. University life presents significant academic, social, and financial challenges, leading to increased stress, anxiety, and depression.
- Conditions
- Mental Disorder, Depression Disorders, Stress, Anxiety
- Trial name
- NCT06885489
- Testing
- Acceptance and Commitment Therapy (ACT) based psychoeducation program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Treatment Resistant Depression
Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine
This study aims to assess the efficacy and safety of intranasal esketamine as maintenance antidepressant therapy in patients who have demonstrated clinical improvement with off-label intravenous racemic ketamine for…
- Trial name
- NCT04856124
- Testing
- Intranasal esketamine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Psych Atlanta
Covid19, Depression
Depression and Anxiety in Long Term Coronavirus Disease COVID-19
Background : Depression and Anxiety are linked to COVID (Coronavirus Disease)-19 long-term impact through several mechanisms. The possible way is the alteration of neurotransmitter regulation from the interaction of severe acute…
- Conditions
- Covid19, Depression, Anxiety
- Trial name
- DALT-COV (NCT04893668)
- Testing
- Depression, Anxiety
- Where
- Indonesia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Restless Legs Syndrome, Sleep Quality
Restless Legs Syndrome and Sleep Quality in Pes Planus
Pes planus, also known as flatfoot, is a common foot deformity that can affect the biomechanics of the lower limbs. However, its relationship with neurological conditions has not been studied extensively.
- Conditions
- Restless Legs Syndrome, Sleep Quality, Pain, Quality of Life
- Trial name
- FLAT-RLS (NCT07117591)
- Where
- Turkey (Türkiye)
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Bozok University
Nursing Caries, Surgical Menopause
The Effect of Nursing Support Program for Women in Surgical Menopause on Their Life Quality
Objective: The aim of this study was to determine the effect of the nursing support program developed in line with the Roy Adaptation Model on the quality of life, sleep quality and depressive symptom status of women in surgical…
- Conditions
- Nursing Caries, Surgical Menopause, Quality of Life
- Trial name
- NCT05809960
- Testing
- Nursing support program, Routine nursing care
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Mehtap Gümüşay
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Cognitive Assessment, Working Memory
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor.
- Conditions
- Cognitive Assessment, Working Memory, Executive Function (Cognition), Sustained Attention
- Trial name
- NCT07319117
- Testing
- Skoshify 'Think Tank' Formulation
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Depression, Anxiety
Cross-Cultural Differences in the Network Structure of Social Anxiety and Body Dysmorphic Symptoms
This study will examine cross-cultural differences in the network structure of social anxiety and body dysmorphic symptoms across Germany, the United States, and Japan.
- Conditions
- Depression, Anxiety, Body Dysmorphic Disorders
- Trial name
- NCT06962917
- Testing
- Cross sectional study
- Where
- Germany
- Volunteers
- 1,523 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Anxiety
Feasibility Study of a Music and Social Support Intervention for Postnatal Mothers/Infants
This research study aims to assess the feasibility of conducting a full scale trial of Mamas in Harmony, a group music and social support class delivered by a professional musician for mothers and their babies.
- Trial name
- NCT05930990
- Testing
- Mamas in Harmony
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Depression
Efficacy of Spanish or English Language Versions of Mindfulness Meditation on Depression
This study explores the differential efficacy of Spanish or English versions of a mindfulness intervention on Depression levels, using a pre test post test design and an active control condition (health education).
- Trial name
- REMAPS (NCT03545074)
- Testing
- Mindful Awareness Practices- English, Mindful Awareness Practices- Spanish, Health Education - English
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Pharmacokinetics and Safety of Desvenlafaxine in Korean Healthy Subjects Following Single and Multiple Oral Doses of Desvenlafaxine Succinate Sustained Release Tablet
To evaluate the pharmacokinetics and safety of single dose and multiple doses of desvenlafaxine in Korean healthy subjects and compare to westerners.
- Trial name
- NCT01443208
- Testing
- desvenlafaxine
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Depression, Anxiety
Online Support Groups for Depression and Anxiety
The purpose of this study is to determine the effectiveness of online support groups for anxiety and depression.
- Trial name
- NCT01149265
- Testing
- Online support group, Expressive writing
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Feasibility, Acceptability
A Digital Resilience Intervention for Emergency Medical Service Workers
Emergency medical service (EMS) workers (i.e., ambulance service providers) experience triple the risk for anxiety, depression, and posttraumatic stress disorder (PTSD) compared to the general U.S. population.
- Conditions
- Feasibility, Acceptability, Adoptability, Meaning Made
- Trial name
- NCT06861400
- Testing
- Self-Reflective Resilience-Recovery Activity Promotion Training
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Syracuse University
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