Clinical trials: Depressive Disorders
Depression, Insulin Resistance
Brain Function in Depression and Insulin Resistance
The purpose of this study is to help researchers learn about how the brain responds to rewards. This study is interested in seeing how these responses differ between people who are more and less responsive to insulin in their…
- Trial name
- NCT02889211
- Testing
- Gambling Task
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Burnout, Professional, Anxiety
Storytelling Through Music to Improve Well-being Among Homeless Service Providers
Homelessness is a complex social issue and requires a dedicated workforce of helping professionals, including nurses and social workers.
- Conditions
- Burnout, Professional, Anxiety, Depression, Secondary Trauma
- Trial name
- NCT06536387
- Testing
- Storytelling Through Music
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stress
A Stress Reduction Program for Companies
This protocol proposes a well-being program based in stress reduction program for employees of a company. objectives: To evaluate the effects of a stress reduction program with a specific orientation for workers and taught to…
- Trial name
- NCT02660307
- Testing
- PROGRESS group
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centro de estudos em Atenção Plena
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06834893)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Healthy Participants
Targeting Large-scale Networks in Depression With Real-time fMRI (Functional Magnetic Resonance Imaging) Neurofeedback
The purpose of this study is to develop a technique called real time fMRI neurofeedback. This technique uses a functional MRI scanner, except that special software allows the researchers to measure activity in participants brain…
- Trial name
- NCT05934604
- Testing
- Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anxiety, Depression
Up-regulating Positive Affect in Emotional Disorders
The aim of this study is to assess the differential effect of two transdiagnostic treatment protocols for emotional disorders (ED) (depression and anxiety disorders) using a randomized pilot study design: a) a transdiagnostic…
- Trial name
- NCT02790398
- Testing
- Transdiagnostic treatment protocol, Transdiagnostic treatment protocol + PA regulation component
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I
Intervention Compliance, Usability
CSDM: A Trial to Improve Communication and Shared Decision Making Using a Web-Based Tool
The goal is to develop a pragmatic, scalable intervention to overcome problems with surrogate decision making in ICUs. The aim is to conduct a pilot study among surrogates and clinicians of 50 incapacitated patients at high risk…
- Conditions
- Intervention Compliance, Usability, Acceptability
- Trial name
- CSDM Pilot (NCT02955563)
- Testing
- CSDM Web-Based Tool Intervention
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Infertility, Male, Depression
Impact of Duloxetine on Male Fertility
The investigators are conducting a placebo-controlled, randomized control trial with duloxetine in healthy, fertile men not previously on any antidepressants.
- Trial name
- NCT03038867
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
Canadian Biomarker Integration Network for Depression Study
This study is a pilot to assess feasibility of the protocol in patients and controls across six participating sites. The goal is to identify biological markers (biomarkers)that can be measured at baseline or early in treatment to…
- Trial name
- CAN-BIND-1 (NCT01655706)
- Testing
- escitalopram, aripiprazole
- Where
- 6 sites in Canada
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Major Depression, Alzheimer's Disease
Retinoic Acid Homeostasis in Neuropsychiatric Diseases
It is hypothesized, that local retinoic acid (RA) homeostasis is functionally involved in the pathophysiology of depression. In a cross-sectional (and partly longitudinal) analysis, serum RA status will be assessed in healthy…
- Conditions
- Major Depression, Alzheimer's Disease, Alcoholism, Schizophrenia
- Trial name
- RAHND (NCT02439099)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Dementia
A Mobile Phone-based Intervention on Dementia Patients' Caregivers in Vietnam
Background: The growing number of older people with dementia increases demand on informal caregivers who lack information and skills, leading to a high psychological burden in care provision.
- Trial name
- NCT04958707
- Testing
- Information including knowledge and skills related to dementia patient care, Usual care
- Where
- 2 sites in Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Pelvic Pain, Depression
Psychosocial Treatment for Women With Depression and Pain
Patients with depression and pain have poorer outcomes in response to depression treatments than depressed patients without pain.
- Trial name
- NCT00895999
- Testing
- Interpersonal Therapy for Pain (IPT-P), Enhanced Support and Connection to Counseling
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
MDD, PMDD
Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a sex-specific depressive disorder where depressive symptom severity drastically changes in relation to menstrual cycle phase.
- Trial name
- NCT06130371
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder, Mood Disorders
Clinical Validation of Samsung Smartwatch
Objective: Wearable technology holds promising potential for mental health monitoring and detection. Samsung has developed an algorithm that they believe can detect signs of depression and anxiety in smartwatch users.
- Conditions
- Major Depressive Disorder, Mood Disorders, Mental Health Issue
- Trial name
- NCT05767593
- Testing
- Wearing Samsung smartwatch and filling out daily surveys
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Happiness, Anxiety
Prosocial Behavior Can Safeguard Mental Health and Foster Emotional Well-being During the COVID-19 Pandemic
The COVID-19 pandemic and the accompanying lockdown measures have made mental health a pressing public health concern. Acts that focus on benefiting others-known as prosocial behaviors-offer one promising intervention that is…
- Conditions
- Happiness, Anxiety, Depression, Morality
- Trial name
- NCT04517006
- Testing
- Self-focused acts, Prosocial acts
- Where
- Canada
- Volunteers
- 1,328 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Depressive Symptoms, Physical Inactivity
COVID-19 Research: COPE Trial in Health Care Workers
The present project is designed to address the problem of elevated depression and stress among health care workers (HCWs). Investigators will test the extent to which a 12-week mobile health aerobic exercise intervention (4…
- Trial name
- NCT05271006
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Autism Spectrum Disorder, Parenting Stress
Feasibility and Acceptability of Laughter Yoga in Children With Autism Spectrum Disorder and Their Parents
This is a pilot randomised controlled trial to explore the acceptability and feasibility of laughter yoga about anxiety and depression reduction in children with ASD and parenting stress reduction for their parents.
- Conditions
- Autism Spectrum Disorder, Parenting Stress, Depression, Anxiety
- Trial name
- NCT06326255
- Testing
- laughter yoga
- Where
- Hong Kong
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- LAM Chung Yan Hemio
Major Depressive Disorder
Brain Imaging Techniques That Predict Antidepressant Responsiveness
Do functional brain changes occur during Venlafaxine ER (extended release) versus Fluoxetine treatment and do changes in selective structures, such as the amygdala, predict treatment response?
- Trial name
- WyethKolden (NCT00909155)
- Testing
- Venlafaxine ERT, Fluoxetine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Depression / Major Depressive Disorder, Anxiety
Activating Voice Journaling for Mental Health With Voice Biomarkers
This retrospective observational study evaluated the relationship between voice characteristics and self-reported mental health symptoms using longitudinal data collected through the Kintsugi Voice Journaling app.
- Trial name
- NCT07789808
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Kintsugi Mindful Wellness, Inc.
Healthy, Perimenopausal Depression
Multidimensional Determinants of Functional Health In Women Aged 45-60
The goal of this observational study is to learn about the multidimensional determinants of functional health in women aged 45 to 60 years.
- Conditions
- Healthy, Perimenopausal Depression, Menopausal Complaints, Bone Mineral Density
- Trial name
- NCT07667699
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kartal City Hospital
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