Clinical trials: Depressive Disorders
Acne Vulgaris
Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of hair follicles on the face, neck…
- Trial name
- NCT06242288
- Testing
- ISOtretinoin 20 MG
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mostafa Bahaa
Stress, Anxiety
Effects of High Ventilation Breathwork With Retention (HVBR) on Health
The investigators are conducting a randomised-controlled trial comparing high ventilation breathwork with retention (HVBR) to a breathwork placebo (paced breathing at 15breaths/min with brief retentions).
- Conditions
- Stress, Anxiety, Depressive Symptoms, Mental Wellbeing
- Trial name
- NCT06064474
- Testing
- High ventilation breathwork with retention (HVBR)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sussex
Depression, Postpartum Depression
Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression?
Our primary aim is to evaluate whether Vitamin D deficiency causes depressive symptoms in antepartum and postpartum depression and whether early correction of Vitamin D deficiency improves these symptoms.
- Trial name
- NCT02272387
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Unipolar Depression, Bipolar Depression
Mechanism of Action of Electroconvulsive Therapy
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
- Trial name
- MoA-ECT (NCT04059952)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Perinatal Depression
Telehealth Group Intervention for Perinatal Depressive Symptoms
The goal of the project is to evaluate for the first time, the effectiveness of using a telehealth approach to reducing perinatal depressive symptoms in diverse groups of childbearing women; urban and rural-dwelling, and from…
- Trial name
- TePOP (NCT03932760)
- Testing
- UPLIFT Program, Attention Control Group
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Utah
Diabetes, Pre-diabetes
Northern Manhattan Study of Metabolism and Mind
Pre-diabetes, type 2 diabetes, and their related conditions, adiposity and insulin resistance, are more prevalent in minorities Northern Manhattan compared to the general population of the United States.
- Conditions
- Diabetes, Pre-diabetes, Cognition - Other, Depressive Symptoms
- Trial name
- NOMEM (NCT02470260)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Bipolar Affective Disorder, Major Depressive Disorder
Exosome for Early Diagnosis of Bipolar Affective Disorder
Objectives: Bipolar disorder (BD) is a chronic and recurrent mental illness characterized by depressive episodes and manic or hypomanic episodes, leading to severe functional impairment and cognitive damage.
- Trial name
- NCT05915312
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Dysphoria
Effects of Transcranial Direct Current Stimulation on Reward Learning in Subclinical Depression.
This project will test whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can alter reward learning behaviour in subclinical depression.
- Trial name
- NCT03393312
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Major Depressive Disorder
Mobile Screening for Major Depressive Disorder in Adults From an Ethnically and Socioeconomically Diverse Population.
Major depressive disorder (MDD) is a mental disorder leading to a variety of emotional and physical problems affecting almost 300 million people worldwide.
- Trial name
- MOOD (NCT05989412)
- Testing
- Patient health questionnaire-9 via the Your Research application
- Where
- Netherlands
- Volunteers
- 1,786 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Bipolar Disorder and Major Depressive Disorder
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their…
- Trial name
- COMET (NCT06740331)
- Testing
- Analysis of social cognition, memory functioning, and executive functioning processes
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Job Satisfaction, Work Performance
Life Skills Training Workplace Prevention Program
A workplace health promotion intervention for youth age 16-24
- Conditions
- Job Satisfaction, Work Performance, Health Care Utilization, Depression Symptoms
- Trial name
- LST-WP (NCT06745739)
- Testing
- Life Skills Training Workplace Prevention Program
- Volunteers
- 1,145 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Depression Disorder
Study on the Antidepressant Effects and Mechanism of Action of Cang-ai Volatile Oil Based on Near-Infrared Functional Brain Imaging and the NT-Trk Signalling Pathway
This project plans to recruit 60 patients with depression, randomly assigning them to either the CAVO group or the bergamot essential oil group, with 30 participants in each.
- Trial name
- NCT07384312
- Testing
- Cang-ai Volatile Oil, Bergamot Essential Oil
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dongdong Qin
Depression
Multi-country Project on the Role of Diet, Food-related Behavior, and Obesity in the Prevention of Depression
The study examines the feasibility and effectiveness of two different nutritional strategies (multi-nutrient supplement and food-related behavioural change) to prevent depression in high-risk overweight European Union citizens.
- Trial name
- MoodFOOD (NCT02529423)
- Testing
- Multi-nutrient supplement, Behavioral Activation
- Where
- 4 sites in Germany, Netherlands and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Sleep and Circadian Problems
Effect of Stellate Ganglion Block on Sleep Quality in Patients With Depression
# Brief Summary This clinical research study looks at whether stellate ganglion block (SGB) can improve sleep quality for people with depression. Poor sleep often goes together with depression.
- Trial name
- NCT07836738
- Testing
- Stellate Ganglion Block
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Li Juan
Depression
Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
This study is looking at the mechanisms underlying the behavioral effects of ketamine in healthy and depressed individuals.
- Trial name
- NCT02037035
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yale University
Angling, Supportive Therapeutic
Investigation of the Effects of Angling as Supportive Therapy in Schizophrenia Treatment on Serum Parameters, Anxiety, Depression, and Quality of Life
This study aims to evaluate the effects of recreational fishing (angling) as a supportive therapeutic intervention in individuals diagnosed with schizophrenia.
- Conditions
- Angling, Supportive Therapeutic, Schizophrenia
- Trial name
- NCT07682935
- Testing
- recreational fishing (angling)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firat University
Postpartum Depression (PPD), Self-Efficacy
NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
The study's objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the…
- Conditions
- Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient
- Trial name
- NURTURE (NCT07214597)
- Testing
- VoiceLove mobile phone application
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Treatment-Resistant Depression
Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology
The goal of this clinical trial is to learn about the characteristics, identify early and intervene effectively in time in Treatment-Resistant Depression.
- Trial name
- NCT05777876
- Testing
- non-invasive transcranial deep brain stimulation, Motor cortex stimulation, non-invasive transcranial deep brain stimulation with closed-loop
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Gamification
Gather.Town Gaming for Pregnant Adolescents With Depression Literacy
Aim The study seeks to: 1. To assess the effect of the Gather.town gaming intervention on promoting depression literacy among pregnant adolescents in Thailand. 2.
- Trial name
- NCT06468020
- Testing
- The Gather.town gaming intervention
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Taiwan University
Anxiety, Depression
Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT) Full Trial
We hypothesize that the intervention will: (1) offer a feasible approach for providing mental healthcare to pregnant women and have a high level of acceptability by pregnant women and healthcare providers; (2) reduce symptoms of…
- Trial name
- NCT01901796
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Calgary
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