Clinical trials: Depressive State
Major Depressive Disorder
International Study to Predict Optimised Treatment - in Depression
The aim of this study is to identify genetic, physical (brain) and psychological (cognitive) markers (or combinations of them) that predict specific response to a range of antidepressants treatment (Escitalopram, Venlafaxine…
- Trial name
- iSPOT-D (NCT00693849)
- Testing
- Escitalopram, Sertraline, Venlafaxine-XR
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 2,688 people, healthy volunteers welcome
- Sponsor
- BRC Operations Pty. Ltd.
Anhedonia, Depression
Computational Cognitive Training To Boost Reward Responsiveness In Anhedonic Patients
Anhedonia, i.e., reduced positive mood and decreased sensitivity to rewards, is observed in many psychiatric illnesses, particularly depression and anxiety disorders.
- Trial name
- NCT05383248
- Testing
- High Reward - High Variance, High Reward - Low Variance
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Depression
Effect of Psychedelic VR-augmented Therapy on Patients With Clinical Depression
Research has demonstrated that psychedelic compounds possess significant therapeutic potential for a variety of disorders, including depression.
- Trial name
- NCT06174285
- Testing
- Therapeutic Intervention with Psychedelic Virtual Reality, Therapeutic Intervention with Non-Psychedelic Virtual Reality
- Where
- Estonia
- Volunteers
- 45 people
- Sponsor
- University of Tartu
Depressive Disorder
Study In Patients With Depression Not Responding to Selective Serotonin Re-uptake Inhibitors
This study is designed to evaluate the efficacy and safety in depressive patients who did not respond sufficiently to selective serotonin re-uptake inhibitors (SSRI).
- Trial name
- NCT00296517
- Testing
- 323U66 (Bupropion Hydrochloride Sustained Release)
- Where
- 62 sites in Japan
- Volunteers
- 325 people
- Sponsor
- GlaxoSmithKline
Depressive Symptoms
Feasibility and Effects of a Blended Baduanjin Exercise and Green Tea Consumption Program on Depressive Symptoms, Gut Microbiota and Quality of Life in Older Adults
Depression is a common mental health issue in older adults, often manifesting as insomnia, low mood, vague somatic complaints, cognitive decline, and recurrent thoughts of death or suicide.
- Trial name
- NCT07687940
- Testing
- blended Baduanjin and Green Tea consumption program, Non-treatment control
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Hong Kong Baptist University
Acquired Brain Injury, Depression
MAPLES Pilot Study for Low Mood in ABI
Low mood and depression are common following acquired brain injury (ABI). There is a lack evidence on effective treatments in ABI. Behavioural Activation (BA) is a potentially valuable option.
- Trial name
- MAPLES (NCT03874650)
- Testing
- Activity Planning Group, Activity Engagement Group, Waitlist Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Cambridge
Major Depressive Disorder
Cognitive Training for Depression II
This study is evaluating the effects of two brain training exercises on: memory, cognitive processing and depression symptoms.
- Trial name
- NCT01934491
- Testing
- Cognitive Training A, Cognitive Training B
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteoarthritis (OA) of the Knee
Investigation of Biopsychosocial Characteristics of Individuals with Knee Osteoarthritis
Since pain and depression are observed together in rheumatic diseases, the concept of limitation caused by the disease and health-related quality of life becomes more determinant than radiological joint damage.
- Trial name
- NCT06591715
- Testing
- Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Aysima Barlak
Depression
Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals
This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.
- Trial name
- NCT00178035
- Testing
- paroxetine, One night of Total Sleep Deprivation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Pittsburgh
Major Depressive Episode
Cohort of Patients Suffering From Major Depressive Episode With Evaluation of Sleep, Circadian Rhythms and Psychiatric Disorders
Despite international efforts to identify biomarkers of depression, none has been transferred to clinical practice, neither for diagnosis, evolution, nor therapeutic response.
- Trial name
- SoPsy-SoSad (NCT05866991)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Sleep
The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression
The aim of this trial is to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression.
- Conditions
- Depression, Sleep, Sleep Disorder, Sleep Disturbance
- Trial name
- EASED (NCT03673397)
- Testing
- Aerobic exercise, bicycle ergometer
- Where
- Switzerland
- Volunteers
- 92 people
- Sponsor
- Oberwaid AG
Depression, Anxiety
Feasibility and Acceptability of W-GenZD vs CBT-light Teletherapy for Adolescents Seeking Mental Health Services
The primary aim of this study is to determine the feasibility and acceptability of the W-GenZD mobile application among a group of adolescents and who have screened and triaged into low-intensity treatment within the Children's…
- Trial name
- NCT05372913
- Testing
- Woebot for Adolescents (W-GenZD) Mobile Application, CBT-Lite Teletherapy Group
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Woebot Health
Depression, Anxiety
Mood Lifters for Undergraduates
Large-scale, effective, low-cost, and evidence-based programs that can nimbly translate new research discoveries into prevention and care for psychosocial-based problems are urgently needed since the vast majority of people who…
- Conditions
- Depression, Anxiety, Mood Disorders, Mental Health Wellness 1
- Trial name
- ML-UP (NCT05684120)
- Testing
- Mood Lifters for Undergraduates
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Delirium, Respiratory Depression
Acupuncture for Sedation in the Intensive Care Unit (ICU)
BACKGROUND Many patients in the trauma intensive care unit (TICU) require mechanical ventilation and sedation or anxiolysis. Mechanical ventilation means that a machine is helping a patient breathe if he can't breathe on his own.
- Conditions
- Delirium, Respiratory Depression, Overmedication
- Trial name
- NCT01362270
- Testing
- Verum Acupuncture
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Premature Birth
Family Nurture Intervention (FNI) in Neonatal Intensive Care Unit (NICU)
The purpose of this study is to test the efficacy of a family nurture intervention in the neonatal intensive care unit (NICU). Infants receiving enhanced mother-infant and family nurture are compared to infants receiving standard…
- Trial name
- NCT01439269
- Testing
- Family Nurture Intervention
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Columbia University
Oral Lichen Planus, Thyroid Disease
Association Between Oral Lichen Planus and Thyroid Disease
The goal of this observational study is to determine the prevalence of thyroid disease in adults with oral lichen planus (OLP) treated at the Dental Hospital of the University of Barcelona (HOUB), and to evaluate the association…
- Trial name
- NCT06550154
- Testing
- Data collection
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Depression, Postpartum
Effectiveness of a Web-based Nursing Intervention in the Reduction of Postpartum Depression and Parenting Stress.
The purpose of the study is to determine whether a web-based nursing intervention delivered during the postpartum period will decrease symptoms of postpartum depression and parenting stress.
- Trial name
- NCT02843022
- Testing
- standardized electronic messages, nurse phone call if requested, Staff nurse phone follow-up
- Where
- United States
- Volunteers
- 683 people, healthy volunteers welcome
- Sponsor
- Saint Anselm College
Subthreshold Depression
Needle-embedding Therapy Alleviates Depressive Symptoms and Resets the Function of Executive Control System in Subthreshold Depression People
The main objective of this trial is to evaluate the effectiveness of treating subthreshold depression by needle-embedding therapy.
- Trial name
- NCT04319562
- Testing
- needle-embedding therapy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Depression, Continuous Antidepressant Abuse
Development of Escitalopram Genomic Device by Using Candidate Gene Approach and Genome-Wide Scanning
To reveal the genetic determinants of the treatment outcome of escitalopram in depressed patients (by using candidate gene approach and whole genome scanning).
- Conditions
- Depression, Continuous Antidepressant Abuse, Adverse Reaction to Drug
- Trial name
- NCT00935246
- Testing
- Escitalopram
- Where
- South Korea
- Volunteers
- 202 people
- Sponsor
- Samsung Medical Center
Bipolar Disorder
Oral Uridine for Treatment of Bipolar Depression in Adolescents
The purpose of the study is to see if the investigational medication uridine reduces depression symptoms in adolescents with bipolar disorder. Uridine is a naturally occurring chemical that is made by the human liver.
- Trial name
- NCT00841269
- Testing
- Uridine
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Utah
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