Clinical trials: Desaturation
Obstructive Sleep Apnea, Cleft Palate
Comparing the Side-lying Sleep Positioning to Back-lying in Infants With Cleft Palate
The craniofacial abnormalities found in infants and children with cleft palate (CP) lead to increased risk of obstructive sleep apnoea (OSA).
- Trial name
- SLUMBRS2 (NCT04478201)
- Testing
- back sleep positioning, side sleep positioning
- Where
- 11 sites in United Kingdom
- Volunteers
- 244 people
- Sponsor
- Manchester University NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Nocturnal Desaturation
The International Nocturnal Oxygen (INOX) Trial
This multicenter randomized placebo controlled trial aims to determine if in patients with COPD not qualifying for LTOT but presenting significant nocturnal arterial oxygen desaturation, whether nocturnal oxygen therapy provided…
- Trial name
- INOX (NCT01044628)
- Testing
- Concentrator
- Where
- 28 sites in Canada, France and 2 more
- Volunteers
- 243 people
- Sponsor
- Laval University
Healthy
SurePulse Oximeter - a Targeted Oxygenation Observation
This clinical investigation will investigate how accurate the SurePulse VS and SurePulse VS Patch (VSP) are for measuring blood oxygen levels (oxygen saturation).
- Trial name
- SPO-TOO (NCT05756816)
- Testing
- SurePulse VSP, SurePulse VS
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Surepulse Medical Limited
Cardiac Disease
Pilot Study of the Feasibility of Multicenter NIRS Data Collection and Interventions for Desaturation in Cardiac Surgery
Using the 9 centers (Appendix B) involved with the planned multicenter NIRS comparative effectiveness trial the specific aims of this study are: 1.
- Trial name
- NCT01765504
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Healthy Vollunteer, Apnea
Temporal Dynamics of Peripheral SpO₂ During Reoxygenation
Pulse oximeters estimate arterial oxyhaemoglobin saturation (SaO₂) from photoplethysmographic signals recorded at peripheral sites (usually the fingertip), thus measuring the peripheral oxygen saturation (SpO₂).
- Trial name
- PulseOx (NCT07884500)
- Testing
- Voluntary Apnea
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Healthy
Desaturation Validation of INVSENSOR00028
This study is designed to measure the trending accuracy of a noninvasive regional oximetry measurement of somatic oxygen saturation. Two large sensors (adult sensors) will be placed on the subject's forehead.
- Trial name
- NCT03704636
- Testing
- INVSENSOR00028
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Pulmonary Disease, Chronic Obstructive
AMBULATORY OXIMETRY MONITORING (AOM): a New Approach to Quantify Oxygen Desaturation in Ambulatory COPD Patients
Chronic obstructive lung disease (COPD) is characterized by airflow obstruction that is progressive over many years and is largely irreversible.
- Trial name
- NCT01873092
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA New York Harbor Healthcare System
COPD, Exercise
Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients
A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training…
- Conditions
- COPD, Exercise, Pulmonary Rehabilitation, Desaturation of Blood
- Trial name
- NCT05825638
- Testing
- Continuous training session, Interval training session
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Groupe Hospitalier du Havre
Healthy
Desaturation Validation of INVSENSOR00031
This study is designed to compare the accuracy of a noninvasive measurement of oxygen saturation compared to reference values obtained by a laboratory blood gas analyzer.
- Trial name
- NCT03783780
- Testing
- INVSENSOR00031
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Chronic Obstructive Pulmonary Disease
Long-term Oxygen Treatment Trial
Chronic obstructive pulmonary disease (COPD) is a serious respiratory disease in which the airways in the lungs are partially blocked, resulting in symptoms of chest tightness, coughing, and difficulty breathing.
- Trial name
- LOTT (NCT00692198)
- Testing
- Supplemental oxygen therapy
- Where
- 39 sites in United States
- Volunteers
- 738 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anesthesia, General
Comparison of Spontaneous Ventilation Time in Air Without Desaturation After Positive Pressure Extubation Versus Aspiration Extubation When Awakening From General Anesthesia
The primary objective is to show that positive pressure extubation improves oxygenation immediately after extubation compared to extubation via "aspiration" by evaluating and comparing the onset time of desaturation during…
- Trial name
- NCT01323049
- Testing
- Positive pressure extubation, Aspiration/suction extubation
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
Postoperative Acute Kidney Injury
Intraoperative Renal Desaturation and Postoperative Acute Kidney Injury
The aim of this study is to investigate the changes in renal regional oxygen saturation (rSO2) monitored by near-infrared spectroscopy (NIRS) and its relationship with the occurrence of postoperative AKI.
- Trial name
- NCT04967105
- Testing
- Near-infrared spectroscopy
- Where
- China
- Volunteers
- 157 people
- Sponsor
- Chinese PLA General Hospital
Airway Management
Apneic Intubation Critically Ill Children
This study compares the actual standard of care of intubation in Swiss pediatric intensive care units vs the use of apneic oxygenation using either high flow or low flow oxygen to prevent hypoxemia and to prolong apnea time…
- Trial name
- Penguin (NCT04890288)
- Testing
- Interventional randomized controled trial (RCT) comparing two oxygenation methods to reduce desaturation during intubation vs standard of care.
- Where
- 7 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Apneic Oxygenation, Endolarengeal Surgery
Oxygen Reserve Index (ORi) in Identifying Desaturation
This randomized clinical trial investigates whether Oxygen Reserve Index (ORi) monitoring enables earlier detection of impending hypoxemia compared with conventional pulse oximetry during apneic intermittent ventilation in adult…
- Conditions
- Apneic Oxygenation, Endolarengeal Surgery, Oxygen Reserve Index
- Trial name
- NCT07415161
- Testing
- oxygen monitoring techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Apnea, Hypoventilation
Peripheral Nerve Stimulation to Reduce Hypoxic Events
This study is designed to determine if using peripheral nerve stimulation in conjunction with pulse oximetry as an adjunct to traditional monitoring in the PACU reduces the frequency and severity of sedation related apnea and…
- Conditions
- Apnea, Hypoventilation, Hypoxemia
- Trial name
- NCT02554110
- Testing
- Stimulator active device
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Pulmonary Vascular Disease, Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Exercise Performance on Ambient Air vs. Low-Flow Liquid Oxygen Therapy in Chronic Lung Diseases
The investigators aim to study the effect of liquid oxygen therapy (4l/min, nasal) )in Swiss residents with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary…
- Conditions
- Pulmonary Vascular Disease, Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Pulmonary Arterial Hypertension (PAH)
- Trial name
- NCT07777367
- Testing
- 6-minute walk distance (6MWD) test on ambient conditions, 6-minute walk distance (6MWD) test with supplemental oxygen (LOX)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Silvia Ulrich Somaini
Neonatal Disorder
Effects of Mother Position in Skin-to-skin Contact Newborn on Oxygen Saturation Levels.
The purpose of this study is to determine if the position of the mother in the first two hours after delivery, while she is in skin to skin contact with your child, influences the oxygen saturation and/or heart rate of the…
- Trial name
- NCT02585492
- Testing
- Head-of-bed elevated 15°, Head-of-bed elevated 45°
- Where
- 7 sites in Spain
- Volunteers
- 1,243 people, healthy volunteers welcome
- Sponsor
- Red Salud Materno Infantil y del Desarrollo
Lung Diseases, Total Intravenous Anesthesia
Effects of Adding Different Drugs for Preventing Cough Induced by Bronchoscopic Spraying of Local Anesthetics
Cough is the most unwanted response during bronchoscopic interventions for hemodynamic instability, hypoxemia, and interruption of interventions.
- Conditions
- Lung Diseases, Total Intravenous Anesthesia, Bronchoscopic Interventions
- Trial name
- NCT05072236
- Testing
- bronchoscopic insertion
- Where
- Taiwan
- Volunteers
- 108 people
- Sponsor
- National Taiwan University Hospital
Cystic Fibrosis
HFNT During Exercise in CF
Cystic fibrosis (CF) is a genetic condition characterised by recurrent lung infections, inflammation and progressive lung damage.
- Trial name
- NCT03965832
- Testing
- HFNT during exercise, Standard oxygen therapy/RA
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust