Clinical trials: Development; Unilateral
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Speech and Language Disorder, Cerebral Palsy
Effect of mCIMT Casting on Speech-language Outcomes in Children With Hemiparesis
Modified constraint-induced movement therapy (mCIMT) has been successfully used with children who have hemiplegia (weakness or paralysis on one side of the body.) mCIMT uses a removable cast during treatment and home exercise…
- Conditions
- Speech and Language Disorder, Cerebral Palsy, Hemiplegia, Hemiparesis
- Trial name
- NCT04259814
- Testing
- Speech-language therapy (SLT), Modified constraint-induced movement therapy (mCIMT)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Shirley Ryan AbilityLab
Cleft Lip, Cleft Palate
Cleft Palate Surgery and Speech Development
Compare the outcome of two primary surgeries techniques (von Langenbeck and Furlow double z-plasty) performed on children with cleft lip/palate to determine if one results in significantly better velopharyngeal competency for…
- Trial name
- NCT00004639
- Testing
- Furlow double z-plasty palatoplasty palate repair, Von Langenbeck palatoplasty palate repair
- Where
- 2 sites in United States, Brazil
- Volunteers
- 475 people
- Sponsor
- University of Florida
Unilateral Cerebral Palsy
Wereables for Upper Limb Functionality in Hemiparesis
The project is configured as a national interventional study that aims to determine the effectiveness of an intervention strategy using wearable technology, tailored to improve function (WeFun-wearable), on the spontaneous use of…
- Trial name
- WeFun (NCT06872736)
- Testing
- WeFun-wearable activated, WeFun-wearable desactivated
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidade da Coruña
Development; Unilateral
Morphological Asymmetry in Elite Female Tennis Players
Humans generally develop a preferred upper and lower extremity. Due to repetitive uneven loading, this gradually results in morphological adaptations to the dominant side of the body.
- Trial name
- AsymFemaleTP (NCT03142243)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Mesial Temporal Lobe Epilepsy
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
The main goals of this clinical study are to learn if AMT-260 is safe and tolerable and works to reduce the frequency of seizures in adults with unilateral mesial temporal lobe epilepsy (MTLE).
- Trial name
- GenTLE (NCT06063850)
- Testing
- AAV9-hSyn1-miGRIK2
- Where
- 18 sites in United States
- Volunteers
- 12 people
- Sponsor
- UniQure Biopharma B.V.
Stroke, Ischemic Stroke
Robotic rEhabilitation sCenario fOr patieNts With NeglECT
The goal of this pilot clinical trial is to develop an integrated motor and cognitive rehabilitation program and evaluate the usability and acceptability of a new virtual reality scenario designed for the MOTORE device.
- Conditions
- Stroke, Ischemic Stroke, Haemorrhagic Stroke, Neglect, Hemispatial
- Trial name
- RECONNECT (NCT06890481)
- Testing
- Upper-limb planar robotic intervention
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Limb Deficiencies
Early Prosthetics in Children With Upper Limb Deficiency
For children with congenital upper limb deficiency, introduction of the prosthesis is guided by clinical experience rather than by Evidence Based Medicine.
- Trial name
- EARLIMB (NCT04851600)
- Testing
- prosthesis
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Lower-Limb Asymmetry, Athletic Performance
Strength- and Velocity-Oriented Unilateral Training in Male Collegiate Team-Sport Players
This randomized, parallel-group study evaluated the effects of an 8-week unilateral resistance training program with strength- and velocity-oriented loading on limb-specific load-velocity relationships and lower-limb asymmetry in…
- Conditions
- Lower-Limb Asymmetry, Athletic Performance, Muscle Strength
- Trial name
- NCT07801885
- Testing
- Strength-Oriented Unilateral Resistance Training, Velocity-Oriented Unilateral Resistance Training
- Where
- China
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- South China Normal University
Unilateral Vocal Cord Paralysis, Central Auditory Processing Disorder
Early UVFP Management Based on Neurological Evidences (ION-UVFP) - Preliminary Study
The purpose of this preliminary study is to help clarify our hypotheses for the longitudinal study by investigating the relationship between vocal cord paralysis and central auditory processes and thus the interpretation of…
- Trial name
- NCT03966183
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Complete Unilateral Cleft Lip
Unilateral Cleft Lip Closure - Development of a New Hybrid Technique
Unilateral cleft lips can be treated with different incision techniques. According to a survey by the American Cleft Palate Association, the Millard II technique is currently used by the majority of US cleft surgeons.
- Trial name
- NCT05102513
- Testing
- Unilateral Cleft Lip Repair: Hybrid Technique, Unilateral Cleft Lip Repair: Millard 2 Technique
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Marco Kesting
Infant Development, Hemiplegia
CIMT and taVNS for Hemiplegia in Infants
Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body.
- Conditions
- Infant Development, Hemiplegia, Constraint Induced Movement Therapy
- Trial name
- NCT05101707
- Testing
- transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical University of South Carolina
Stroke, Unilateral Spatial Neglect
Therapeutic Serious Game and Rehabilitation of Stroke Patient
The growing field of new technologies offers new perspectives for neurorehabilitation. Serious games are a promising solution in the rehabilitation of cognitive impairments, and they may be useful in the rehabilitation of…
- Trial name
- NCT05661396
- Testing
- Serious game rehabilitation
- Volunteers
- 6 people
- Sponsor
- Hopitaux de Saint-Maurice
Gait, Spastic, Reliability
Reliability of Newly-acquired Gait in Toddlers With a Typical Development and a Unilateral Cerebral Palsy
gait reliability study of toddlers with typically developing and with unilateral cerebral palsy during the first 6 months of independent walking
- Trial name
- ReliabBB-AQM (NCT04559776)
- Testing
- gait analysis
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Clinical Center for Neuropsychomotor Recovery for Children Dr. Nicolae Robanescu
Cleft Palate, Cleft Lip
Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty
Early neonatal cheiloplasty is modified surgery protocol applied in the first week of newborn's life used for treating orofacial cleft patients.
- Conditions
- Cleft Palate, Cleft Lip, Cleft Lip and Palate, Cleft Lip, Bilateral
- Trial name
- NCT03839290
- Testing
- Early neonatal cheiloplasty
- Where
- Czechia
- Volunteers
- 137 people
- Sponsor
- Charles University, Czech Republic
Developmental Dysplasia of the Hip
Mid-term Functional Comparisons of Unilateral and Bilateral Developmental Dysplasia of the Hip
The annual number of live births in Türkiye is 1,112,859 in 2020 and the estimated incidence of developmental dysplasia of the hip (DDH) is between 5 and 15 per 1000 live births.
- Trial name
- NCT05853510
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Pamukkale University
Hip Developmental Dysplasia
Effect of Cross-legged Sitting Among Patients With Unilateral Hip Developmental Dysplasia
One of the most common infant developmental diseases is Hip dysplasia which is mostly seen among female' babies and leads to hip instability due to partial or full hip dislocation [1].
- Trial name
- NCT07002840
- Testing
- Cross- legged sitting position, Physical Therapy Rehabilitation Program
- Volunteers
- 16 people
- Sponsor
- Jouf University
Unilateral Cleft Lip and Palate, Cleft Lip
Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients
The purpose of this study is to evaluate which surgical protocol for treating Unilateral Cleft Lip and Palate (UCLP), a single or two stage repair ( with hard palate late closure) will have less impact in mid facial growth.
- Conditions
- Unilateral Cleft Lip and Palate, Cleft Lip, Cleft Palate, Developmental Disabilities
- Trial name
- NCT02329509
- Testing
- two stage palate surgical repair, One stage Palate Surgical repair
- Volunteers
- 64 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Stroke, Unilateral Spatial Neglect
Serious Game Therapy in Neglect Patients
The growing field of new technologies offers new perspectives for neurorehabilitation. Serious games are a promising solution in the rehabilitation of cognitive impairments, and they may be useful in the rehabilitation of…
- Trial name
- NCT05805748
- Testing
- serious game rehabilitation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
Development; Unilateral
The Degree, Development and Interrelationship of Structural and Functional Asymmetry in (Pre)Adolescent Elite Tennis Players
Humans generally develop a preferred upper and lower extremity. Due to repetitive uneven loading, this gradually results in structural (e.g. increased bone and muscle mass) and functional (e.g.
- Trial name
- AsymTen (NCT03128814)
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Laurent Chapelle