Clinical trials: Dexamethasone
Pulpitis - Irreversible
Enhancing Anaesthetic Success in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Comparative Randomized Controlled Trial
The goal of this clinical trial is to assess the effect of Preoperative intraligamentary corticosteroids injection Cryotherapy which is cold application on : Hard tooth structure ( crown of the tooth ) Soft tissue overlying roots…
- Trial name
- NCT06330519
- Testing
- Dexamethasone sodium phosphate injection, 1,1,1,2 tetrafluoroethane, intraoral soft tissue cryotherapy
- Where
- Egypt
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Pain
Intrathecal Pethidine Plus Dexamethasone for Distal Lower Orthopedic Surgeries
Bupivacaine is commonly used as a sole agent for spinal anesthesia unlike pethidine. Pethidine (meperidine) is a unique opioid. In addition to its analgesic activity, it also has significant local anesthetic activity.
- Trial name
- NCT05303311
- Testing
- Bupivacaine Hydrochloride, Pethidine plus Dexamethasone
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Neuromuscular Block, Residual, Pain
Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty.
- Conditions
- Neuromuscular Block, Residual, Pain, Postoperative Nausea
- Trial name
- NCT07187037
- Testing
- Methylprednisolone (MP), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Multiple Myeloma
Study of KIR-Ligand Mismatched Haplo-Identical Natural Killer Cells Transfused Before Autologous Stem Cell Transplant
The purpose of this study is to induce anti-myeloma responses in patients with high risk or relapsed myeloma using combination chemo- and immunotherapy comprising sequentially: 1) lymphoid and myeloid suppressive conditioning, 2)…
- Trial name
- NCT00089453
- Testing
- Dexamethasone, Cyclophosphamide, Melphalan
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Type 2 Diabetes
Insulinotropic Effect of GLP-1 and GIP After Dexamethasone
In this study we examine whether inducing insulin resistance by dexamethasone in healthy volunteers will lead to a decreased insulinotropic effect of the hormones GLP-1 and GIP.
- Trial name
- NCT02235584
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Pain
Comparison of Post Operative Endodontic Pain in Patients With Irreversible Pulpitis Treated With and Without Dexamethasone.
Root canal procedure is a common procedure in dentistry. Acute inflammatory response in peri-radicular tissues after root canal treatment is the main cause of post op pain.
- Trial name
- NCT06432712
- Testing
- Dexamethasone 4mg
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shoaib Rahim
Adult Patients Undergoing Elective Surgery With General Anesthesia and LMA Insertion
Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Pain After Laryngeal Mask Insertion
This study aimed to compare the efficacy between lidocaine inhalation vs intravenous dexamethasone to reduce pain after laryngeal mask insertion
- Trial name
- NCT03139591
- Testing
- lidocaine inhalation; intravenous dexamethasone
- Where
- Indonesia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Anesthesia, Local
Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block
This is a prospective randomized controlled triple-masked study looking at the duration of nerve block analgesia when using the listed adjuvants (dexamethasone, buprenorphine and clonidine) plus ropivacaine versus plain…
- Trial name
- NCT03117140
- Testing
- Ropivacaine 0.75%, Ropivacaine 0.75% + 300 mcg Buprenorphine, Ropivacaine 0.75% + 75 mcg clonidine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Melinda Seering
Post Operative Nausea and Vomiting
Aromatherapy for Prevention of Intrathecal Morphine Induced Nausea and Vomiting
This study evaluates the effect of combining non pharmacological anti emetic prophylaxis, namely peppermint essential oil to granisetron and dexamethasone in patient who receive intrathecal morphine for lower segment cesarean…
- Trial name
- NCT03434340
- Testing
- Peppermint essential oil, Granisetron, Dexamethasone
- Where
- Malaysia
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Allogeneic Granulocyte Donation
Improving White Blood Cell Collection From Healthy Donors
Background: White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells.
- Trial name
- NCT01553214
- Testing
- Filgrastim, Dexamethasone
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Dexamethasone Administration, Post Extraction Complication
The Effectiveness of Using a Single Post-operative Intramuscular Dexamethasone Injection on Patients with Surgical Extraction of Lower Third Molar
Evaluating the effectiveness of using a single immediate postoperative intramuscular Dexamethasone injection on pain, swelling, trismus and tissue healing in the first seven days.
- Trial name
- NCT06809855
- Testing
- Dexamethasone
- Where
- Iraq
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yassir R. Al-khannaq
Healthy
Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions
CAR is short for cortisol awakening response. The neural mechanism of CAR effect on high-order cognition and social cognition is less known...
- Trial name
- NMCARSEHHSC (NCT02799134)
- Testing
- Dexamethasone, Vitamin C
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- qinshaozheng
Pain, Postoperative
The Effect of IV Dexamethasone on the Duration of Analgesia of Spinal Anaesthesia for C-Sections at a Jamaican Hospital
Dexamethasone is one of many adjuncts tested to prolong the duration of spinal anesthesia and its analgesic effect. The intent of this, a single-site, double-blinded, randomized controlled trial, is to determine if a single…
- Trial name
- NCT04624360
- Testing
- Dexamethasone
- Where
- Jamaica
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Dry Eye Syndromes
ACCURATE Study for Subjects With Dry Eyes
To determine treatment and imaging outcomes in bilateral ocular surface disease management with an intracanalicular dexamethasone (0.4 mg) insert compared to standard topical over-the-counter artificial tears lubrication…
- Trial name
- ACCURATE (NCT04237012)
- Testing
- Dextenza 0.4Mg Intracanalicular Insert, Over the counter Artificial tears
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Eye Centers of Racine and Kenosha
Diabetic Macular Edema
Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema
This study is an interventional, prospective randomized study comparing the dexamethasone implant to intravitreal aflibercept. Subjects will have an initial single injection of aflibercept and will be randomized if diabetic…
- Trial name
- PRECISION (NCT04411693)
- Testing
- Dexamethasone implant, Aflibercept
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Non-Ischemic Central Retinal Vein Occlusion
Effect of Ozurdex® 0.7 mg on Improvement of Efficacy of Bevacizumab for Central Retinal Vein Occlusion
This is a study designed to determine if the addition of Ozurdex® to bevacizumab (Avastin®) eye injections reduces the need for repeat bevacizumab eye injections in patients with nonischemic central retina vein occlusion.
- Trial name
- NCT01295112
- Testing
- Active bevacizumab and Active dexamethasone
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Texas Retina Associates
PONV
Granisetron vs Granisetron and Dexamethasone on the Reduction of Postoperative Nausea and Vomiting
Intrathecal morphine (ITM) has proven to be excellent in reducing postoperative pain. However, its use has commonly been associated with the occurrence of postoperative nausea and vomiting (PONV).
- Trial name
- NCT04570592
- Testing
- Granisetron 1 Mg/mL Intravenous Solution And Dexamethasone 4mg, Granisetron 1 Mg/mL Intravenous Solution
- Where
- Malaysia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Post Operative Pain, Nausea
Effects of Perioperative Intravenous Dexamethasone on Pain in Out Patient Knee Surgery
The purpose of the study is to determine the opiate sparing effects of intravenously administered dexamethasone in outpatient knee surgery. Dexamethasone is a glucocorticoid with well known antiemetic effects.
- Trial name
- NCT01149616
- Testing
- Dexamethasone 8mg iv x1
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Dry Eye
The DEPOT Study (Dry Eye Prescription Options for Therapy)
Assessing DEXTENZA efficacy and safety when placed within the lower eyelid canaliculus for dry eye flares in comparison to topical loteprednol suspension.
- Trial name
- NCT04911361
- Testing
- Dexamethasone
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Post-endodontic Pain
Comparison Of The Effect Of Final Rinse Of Tramadol and Dexamethasone on Post-Endodontic Pain in Teeth With SIP
Briefly, 105 teeth with symptomatic irreversible pulpitis will be included in the study and randomly allocated to three groups (A, B and C).
- Trial name
- NCT07036237
- Testing
- Tramadol group, Dexamethasone Group
- Where
- Pakistan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences