Clinical trials: Dexmedetomidine Analgesia
Epidural Analgesia
Comparative Study Between Two Adjuvant Drugs to Bupivacaine for Post-operative Epidural Analgesia in Abdominal Surgeries
Epidural analgesia is associated with early postoperative mobilization and rehabilitation with minimally associated pain and discomfort.
- Trial name
- NCT05323214
- Testing
- Control Analgesic regimen, Fentanyl Analgesic regimen, Dexmedetomidine Analgesic regimen
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Epidural Anesthesia, Labor Pain
Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia
The aim of this study is to compare epidural dexmedetomidine vs nalbuphine added to bupivacaine in labor analgesia and determine the privilege of one over the other and to compare the effect of both analgesics after delivery.
- Trial name
- NCT05327088
- Testing
- Dexmedetomidine, Nalbuphine
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Regional Anesthesia Morbidity, Supratentorial Brain Tumor
Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries
Supratentorial brain tumor surgeries are associated with significant nociceptive stimulation and postoperative pain, which may adversely affect patient outcomes.
- Conditions
- Regional Anesthesia Morbidity, Supratentorial Brain Tumor, Acute Pain
- Trial name
- NCT07698665
- Testing
- Scalp Block with Bupivacaine
- Where
- 2 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Spine Surgery
The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.
This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain…
- Trial name
- NCT07365800
- Testing
- Methadone-dexmedetomidine-ketamine combination
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- University of Missouri-Columbia
Tonsillitis
Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy
The primary purpose of this study is: 1. To compare dexmedetomidine with fentanyl in terms of intra-operative hemodynamics and post-operative analgesia. 2. To determine an analgesic dose response relationship for dexmedetomidine.
- Trial name
- DexT&A (NCT00654511)
- Testing
- Fentanyl, Dexmedetomidine
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Spermatic Cord Block
Magnesium Sulfate in Combination With Dexmedetomidine As Adjuvants to Levobupivacaine
Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or .
- Trial name
- NCT04498351
- Testing
- Control Test, Dexmedetomidine, Dexmedetomidine and magnesium sulphate
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pain, Postoperative, Pain, Acute
Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries
The aim of this study will be to compare the effects of morphine versus dexmedetomidine when used as adjuvants to local anesthetic (Ropivacaine) in Erector Spinae Plane Block under ultrasound guidance.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Morphine
- Trial name
- NCT05843344
- Testing
- erector spinae plane block with a combination of ropivacaine and morphine, erector spinae plane block with a combination of ropivacaine and dexmedetomidine, erector spinae plane block with ropivacaine only
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Dr Kassiani Theodoraki
Inguinal Hernia, Analgesia
Dexmedetomidine in TAP Block for Inguinal Hernia Repair
This prospective double-blind randomized study will aim at evaluating the short- and long-term postoperative analgesic efficacy of the ultrasound-guided transversus abdominis plane (TAP) block with a combination of local…
- Conditions
- Inguinal Hernia, Analgesia, Pain, Acute, Pain, Chronic
- Trial name
- TAP-dex (NCT04403711)
- Testing
- local anesthetic and dexmedetomidine
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Dexmedetomidine, Transurethral Resection of Prostate
Intrathecal Versus Intravenous Dexmeditomedine in Transurethral Resection of the Prostate
This study is to evaluate The analgesic effect of intrathecal versus intravenous dexmeditomedine in transurethral resection of the prostate
- Conditions
- Dexmedetomidine, Transurethral Resection of Prostate, Intravenous, Intrathecal
- Trial name
- NCT04618965
- Testing
- control group, Intrathecal dexmedetomidine, Intravenous dexmedetomidine
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tanta University
Analgesia, Pain, Acute
Duration of Analgesia With Dexmedetomidine and Ropivacaine in Brachial Plexus Block
This is a prospective, randomized, double blind study of adding dexmedetomidine to ropivacaine for Brachial plexus block and assessing the analgesia with VAS pain scales(0-10), Satisfaction scale by VAS scale(0-10) and time to…
- Conditions
- Analgesia, Pain, Acute, Peripheral Nerve Block
- Trial name
- NCT03385967
- Testing
- Dexmedetomidine, ropivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Pain, Postoperative
Intraperitoneal Dexmedetomidine for Post-laparoscopic Appendicectomy Pain Management in Children
Fifty two children of American Society of Anesthesiologists (ASA) physical status I and II, aged 8-14 years old, of both gender, with suspected acute appendicitis scheduled for laparoscopic appendicectomy, were included in this…
- Trial name
- NCT03067740
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Zagazig University
Anesthesia
The Efficacy of Adding Dexmedetomidine Perineurally to Bupivacaine in Ultrasound Guided Fascia Iliaca Block Versus Intravenously Infused Dexmedetomidine on Hemodynamic Stability Intraoperatively and Postoperative Analgesia Following Hip Arthroscopy
The current study aims to assess effectiveness of dexmedetomidine as adjuvant to general anesthesia on the hemodynamic stability and narcotic consumption intraoperatively and its effect as adjuvant to fascia iliaca compartment…
- Trial name
- NCT04917029
- Testing
- Bupivacaine hydrochloride perineurally, Dexmedetmidine infusion, Dexmedetomidine perineurally
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Sedation, Analgesia
Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic Requirement
Assess impact of increasing dose of dexmedetomidine on total daily dose of fentanyl and propofol while maintaining sedation in a mechanically ventilated patient in a general medical intensive care unit.
- Trial name
- NCT00852046
- Testing
- Dexmedetomidine
- Sponsor
- Avera McKennan Hospital & University Health Center
Nose Diseases
Pre-emptive Analgesia Using Nebulized Ketamine Versus Nebulized Dexmedetomidine in Endoscopic Nasal Surgeries
this study aims to compare the efficacy of pre-emptive nebulized ketamine versus nebulized dexmedetomidine for post operative pain relief in endoscopic nasal surgery
- Trial name
- NCT07056582
- Testing
- Dexmedetomidine, Ketamine, 0.9%sodium chloride
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Sohag University
164 Boys for Hypospadias Surgery Under General Anesthesia With Caudal Block
Caudal Dexmedetomidine Analgesia in Pediatrics .
Dexmedetomidine (DEXM) is a highly selective α2-adrenoceptor agonist that has been used increasingly in pediatric anesthesia. This prospective double blinded randomized comparative study is designed to evaluate the analgesic…
- Trial name
- NCT03791879
- Testing
- Caudal dexamedatomidine analgesia
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Mansoura University
Ketamine-Induced Mood Disorder
The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia
Optimal multimodal opioid-sparing analgesic technique is considered as one of the most important Enhanced recovery pathways (ERPs) or enhanced recovery after surgery (ERAS) interventions that mitigate the undesirable effects of…
- Trial name
- NCT05474183
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Therapy, Pain Management
Intrathecal Ketamine, Dexmedetomidine and Both With Bupivacaine for Postoperative Abdominal Cancer Surgery Pain
Currently, opioids are widely used for pain relief, but they often provide sub-optimal analgesia with occasional serious side effects.
- Trial name
- NCT02455609
- Testing
- intrathecal drug administration, Dexmedetomidine, ketamine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Acute Pain
Dexmedetomidine,Ketamine and Their Combination to Bupivicaine on Thoracic Epidural Analgesia
This study investigate the effect of addition dexmedetomidine, ketamine or their combination to bupivacaine in thoracic epidural analgesia on acute postoperative pain after breast cancer surgery.
- Trial name
- NCT03063671
- Testing
- Ketamine, bupivacine,dexmedetomidine
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Labor Analgesia, Labor Pain
Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia
Females who have experienced normal labor for child birth have claimed it to be most difficult and distressing moments of their life due to excruciating and unbearable pain.
- Trial name
- NCT06550414
- Testing
- Dexmedetomidine, Bupivacain
- Where
- Pakistan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan