Clinical trials: Diabetes, Type I
Diabetes Mellitus
Compare Blood Sugar Level Between Lantus in the Morning and Other Insulins in Type 1 Diabetes Adolescents
The purpose of the study is to compare the effect in blood sugar control between Lantus and twice daily intermediate acting insulins (NPH or Lente) when used as the basal insulin in a multiple daily injection setting with fast…
- Trial name
- NCT00046501
- Testing
- Lantus (insulin glargine [rDNA origin] injection), Humulin N, Humulin L
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Sanofi
Type 1 Diabetes
Glucose-stimulated Pancreatic Islet and Intestinal Blood Flow in Healthy Subjects and in Type 1 Diabetes
Type 1 diabetes is the major type of diabetes in the young. The pathophysiology still needs clarification in order to reach feasible means of preventing the disease.
- Trial name
- ISLET-PET (NCT02547337)
- Where
- Finland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Type1 Diabetes Mellitus
Ovarian Reserve in Diabetes Mellitus
Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. Hyperglycemic condition in diabetes can cause organ damage.
- Trial name
- NCT03859856
- Testing
- hormone panel and ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Type 1 Diabetes
Incretin Effect on the Immunological Phenotype
Assessment of the effect of incretin based therapies (Liraglutide and Saxagliptin) on immune cells in healthy subjects and patients with type 1 diabetes
- Trial name
- NCT01782261
- Testing
- Liraglutide, Saxagliptin
- Where
- Austria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Diabetes Mellitus, Type 1
Testing an Integrated Care Model Trial
This study aims to test the use of an adapted collaborative care model for improving the health outcomes of adults diagnosed with type 1 diabetes (T1D). The duration of the study is 18 months with 4 study survey points.
- Trial name
- NCT06448429
- Testing
- Usual care, Collaborative care model (CoCM)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Type 1 Diabetes, Hypoglycemia
Impact of Hypoglycemia Unawareness on Brain Metabolism Cognition in T1DM
The research study is designed to examine the impact of low blood sugar on brain function in individuals with Type 1 Diabetes who have frequent and severe hypoglycemia (low blood sugar) compared to those who do not.
- Trial name
- NCT00575783
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Yale University
Hypothyroidism
Hypothyroidism in Patients With Type 1 Diabetes
Therefore, for early detection of hypothyroidism in children with type 1 diabetes, it is suggested to measure anti-thyroid antibodies and thyroid stimulating hormone at disease onset and in yearly intervals after the age of 12…
- Trial name
- NCT03257566
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 1 Diabetes
Promoting Adolescent Investment In Diabetes Care
Two financial incentive strategies targeting adolescents with type 1 diabetes will be compared to usual care for motivating adolescents to engage in improved self-care to manage their diabetes.
- Trial name
- InvesT1D (NCT04516694)
- Testing
- Financial incentive (gain), Financial incentive (loss)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Harvard Pilgrim Health Care
Diabetes Mellitus, Type 1
Pharmacology of Insulin Injected With Jet-Injection
The purpose of this study is to compare the pharmacological profile of insulin administered with jet-injection with that of insulin injected with a conventional insulin pen.
- Trial name
- NCT00983775
- Testing
- jet injector (SQ pen/Novopen III)
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy Volunteers, Type 1 Diabetes
Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients
First in human study to understand the potential side effects of MTX-101, how long MTX-101 lasts in the human body, and how MTX-101 affects specific human immune cells.
- Trial name
- NCT06324604
- Testing
- MTX-101
- Where
- 3 sites in Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mozart Therapeutics Australia Pty Ltd
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Effects of HBO on Glucose in Patients With DM
The purpose of this Research Study is: 1. To determine the reliability and performance of the Dexcom G6® continuous glucose monitoring (CGM) system in patients with diabetes undergoing hyperbaric oxygen (HBO2) exposure.
- Trial name
- NCT04261738
- Testing
- Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Legacy Health System
Type 1 Diabetes
Muscle Oxygenation, Type 1 Diabetes, and Glycated Hemoglobin
Most of the studies concerning aerobic fitness in Type 1 diabetic patients noted a relationship between impaired aerobic fitness and high glycated haemoglobin (HbA1c) levels, reflecting poor long term glycaemic control.
- Trial name
- OXYDIAB (NCT02051504)
- Testing
- Incremental maximal exercise, Oral Glucose Tolerance Test, Muscle biopsy
- Where
- France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Type1diabetes, Diabetes Mellitus, Type 1
Genetics Of Autoimmunity In Type I Diabetes
The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes.
- Conditions
- Type1diabetes, Diabetes Mellitus, Type 1, Type1 Diabetes Mellitus, Diabetes Mellitus
- Trial name
- NCT03648918
- Testing
- Blood Collection
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome in Type 1 Diabetes
BACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
- Trial name
- NCT07490964
- Testing
- Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Metabolic Effects of Exogenous 3-hydroxybutyrate in Patients With Type 1 Diabetes and Healthy Controls
The main objective of this clinical trial is to study the metabolic effects of intravenous infusion of the ketone body, 3-hydroxybutyrate (3-OHB), in patients with type 1 diabetes and healthy control subjects.
- Trial name
- NCT04656236
- Testing
- 3-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy, Diabetes Mellitus Type 1
The Effect of Light Therapy on Cellular Energy and Oxidative Stress in Healthy Adults and Type 1 Diabetic Patients
The goal of this clinical trial is to evaluate the effects of low-level light therapy on cellular energy and oxidative stress in healthy adults and patients with Type 1 diabetes.
- Trial name
- PBM-T1D (NCT07833865)
- Testing
- Red and Near-Infrared Light Therapy Pad
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thi-Qar
Diabetes
The Effect of Gastric Emptying on Blood Glucose Profile of Type 1 Diabetes Mellitus and Its Therapeutic Strategies
Establish a cohort study to describe the characteristics of gastric emptying in patients with type 1 diabetes, and adjust the timing of insulin injection during meals to improve blood glucose fluctuations according to the speed…
- Trial name
- NCT06173934
- Testing
- insulin injection 15 minutes before meals, Insulin injection 15 minutes after eating
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type 1 Diabetes
Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.
- Trial name
- T-St1M (NCT04449198)
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Augusta University
Type1diabetes, Parents
Parents of Young Adults With Type 1 Diabetes: An Exploratory Study
The purpose of this mixed-methods study is to explore the lived experience of parents of young adults ages 18 to 25 years with type 1 diabetes who are transitioning to independence, and to test the preliminary efficacy of a…
- Trial name
- NCT03158415
- Testing
- T1DToolkit.org mobile diabetes education
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Immunosuppression, Hyperlipidemias
Cholesterol and Fatty Acid Synthesis in Islet and Liver Transplant Patients and Effect of Dietary Intervention
The purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant…
- Conditions
- Immunosuppression, Hyperlipidemias, Diabetes Mellitus, Type 1
- Trial name
- NCT00947635
- Testing
- Dietary intervention - supplements
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta