Clinical trials: Diabetes, active
Lipodystrophy, Diabetes
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
Background: Generalized lipodystrophy can cause high blood fat levels and resistance to insulin. This can lead to health problems including diabetes.
- Conditions
- Lipodystrophy, Diabetes, Hyperlipidemia
- Trial name
- NCT02262832
- Testing
- Metreleptin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus
Multicenter Assessment of the Pancreas in Type 1 Diabetes
The overall goal of this research is to develop and validate standard operating procedures (SOP) to assess the human pancreas in individuals with type 1 diabetes (T1D) and other forms of diabetes using advanced, quantitative…
- Trial name
- MAP-T1D (NCT03585153)
- Testing
- Non-contrast magnetic resonance imaging
- Where
- 5 sites in United States, Australia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Peripheral Artery Disease, Diabetes Mellitus
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical…
- Conditions
- Peripheral Artery Disease, Diabetes Mellitus, Chronic Limb-Threatening Ischemia
- Trial name
- NCT03622359
- Testing
- SPECT/CT perfusion imaging, PET/CT perfusion imaging
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Charcot Joint of Foot, Osteoarthropathy
Factors Associated With an Evolution in the Quality of Life of Diabetic Patients With Chronic, Wound-free Charcot Foot
Charcot foot, characterized by progressive destructive damage to bone, soft tissue and tendons, involving joint dislocation in the ankle and foot, is a complication of diabetes that is still poorly understood by patients and…
- Trial name
- CHARQUAM (NCT05491577)
- Testing
- Filling in the SF-36, FAAM-F, PHQ-9, PHQ-2 and the simplified version of the EPICES score questionnaire
- Where
- 17 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Diabetes Mellitus, Type 2, Insulin Dependent Diabetes
Diabetes Toolkit at Discharge
The purpose of this randomized clinical trial is to implement the DM Discharge Toolkit into hospital discharge and assess the effect of the DM Discharge Toolkit on patients newly requiring insulin.
- Trial name
- NCT05663931
- Testing
- DM Discharge Toolkit
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Hypertension, Systolic, Metabolic Syndrome
Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure
The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over one week in patients with metabolic…
- Conditions
- Hypertension, Systolic, Metabolic Syndrome, Typ 2 Diabetes
- Trial name
- APCIQ-BP (NCT05903950)
- Testing
- Air cleaners with HEPA filter, Air cleaners without HEPA filter
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Weill Cornell Medical College in Qatar
Overweight and Obesity
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
AZD9550, previously being developed for the treatment NASH, is a dual GCG and GLP-1 receptor agonist. AZD9550 is now being developed in combination with AZD6234, a SARA, for the treatment of overweight and obesity and its…
- Trial name
- CONTEMPO (NCT06151964)
- Testing
- AZD9550, AZD9550 and AZD6234
- Where
- 15 sites in Austria, Canada and 3 more
- Volunteers
- 166 people
- Sponsor
- AstraZeneca
Type 2 Diabetes
Remotely Delivered Mindfulness-Based Diabetes Education
Diabetes distress is common affecting over one-third of people with type 2 diabetes, negatively impacting self-management and outcomes, and disproportionately affecting low-income individuals.
- Trial name
- NCT06312553
- Testing
- Remotely delivered Mindfulness-Based Diabetes Education, Standard Diabetes Self Management Education
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Adverse Pregnancy Outcomes, Cardiovascular Diseases
A Randomized Trial to Reduce Blood Pressure at One Year Postpartum After Preeclampsia
GESTA-COR is a prospective, randomized clinical trial designed to evaluate whether an early, personalized cardiovascular prevention strategy can achieve a clinically meaningful 6 mmHg reduction in systolic blood pressure at one…
- Trial name
- GESTA-COR (NCT06798649)
- Testing
- The intervention in the GESTACOR study involves providing detailed feedback from vascular imaging to women who have experienced adverse pregnancy outcomes (APOs).
- Volunteers
- 150 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Glucose Metabolism Disorders (Including Diabetes Mellitus)
Continuous Glucose Monitoring in Patients Undergoing Cardiopulmonary Bypass
The purpose of this research study is to test the accuracy of the Dexcom continuous glucose monitoring device during the cardiothoracic surgical procedure and recovery period in the Cardiac Intensive Care Unit.
- Trial name
- NCT06861881
- Testing
- Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus (T2DM)
Flaxseed Consumption on Biochemical and Quality of Life in Type 2 Diabetes
The main goal of this clinical trial is to determine the effect of flaxseed added to the diet on biochemical parameters and quality of life in patients with Type 2 diabetes mellitus (T2DM).
- Trial name
- NCT06911060
- Testing
- Flaxseed, Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ondokuz Mayıs University
Type 1 Diabetes
Early Detection of Type 1 Diabetes in First Degree Relatives of Type 1 Diabetes Patients (DETECT T1D GULF)
The aim of this research is to identify pre-symptomatic Type 1 Diabetes (T1D) in young children and adolescents who have first degree relatives with T1D.
- Trial name
- NCT07038473
- Testing
- Investigational Procedure
- Where
- 7 sites in Kuwait, Saudi Arabia and 1 more
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Sanofi
Nephrotic Syndrome, Lipodystrophy
Effects of Meal Macronutrients on Postprandial Lipids
Background: Abnormal fats in the blood can lead to many problems, including heart disease. Researchers want to learn more about how eating meals with different levels of nutrients affects fats in the blood.
- Conditions
- Nephrotic Syndrome, Lipodystrophy, Metabolic Syndrome, Healthy Volunteer
- Trial name
- NCT07313787
- Testing
- High carb then high fat breakfast, High fat then high carb breakfast
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Obesity, Diabetes
Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and Adults
Background: Diabetes and obesity are chronic diseases. They can affect blood flow and how the body processes nutrients, and complications over time can lead to early death.
- Conditions
- Obesity, Diabetes, Metabolic Disorders
- Trial name
- NCT07388537
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lung Adenocarcinoma
PHOENIX: QL1706 Plus Chemotherapy and Bevacizumab in AGA-Resistant, PD-L1 ≥50% Non-Squamous NSCLC
The goal of this Phase II clinical trial (The PHOENIX Study) is to evaluate if the combination of QL1706 (Iparomlimab and Tuvonralimab), bevacizumab, and chemotherapy can treat patients with TKI-refractory, driver-gene positive…
- Trial name
- PHOENIX (NCT07416058)
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CLTA-4)
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Guangdong Association of Clinical Trials
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Longitudinal Observational Study of Diabetic Retinopathy Progression in Type 2 Diabetes Patients
The purpose of this clinical study is to explore structural and functional imaging and systemic biomarkers of diabetic retinopathy (DR) progression, in eyes from Type 2 Diabetes (T2D) patients with moderate to severe…
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Diabetic Complication, Retinal Disease
- Trial name
- IMPORTANT (NCT07458516)
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetes, Gestational, Pre-eclampsia
Usability Evaluation of Gen AI-based Nutrition Chatbot for Pregnant Women
Background: Pregnancy imposes significant physical demands, with complications like gestational diabetes (GDM) and pre-eclampsia posing serious risks.
- Conditions
- Diabetes, Gestational, Pre-eclampsia, AI Chatbot for Prenatal Nutrition Guidance
- Trial name
- NCT07458997
- Testing
- a culturally tailored nutrition AI chatbot for pregnant women
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Hong Kong Metropolitan University
Blood Cholesterol, Blood Pressure Monitoring
Empowering Faith-based Communities to Provide Personalized Diabetes Self-management Education and Support (DSMES) in the Magic City
In this study, individuals living with diabetes in the Birmingham area will participate in a free, 3-month DSMES program hosted by MedsPLUS Consulting, a local independent pharmacy and wellness center, at a local faith-based…
- Conditions
- Blood Cholesterol, Blood Pressure Monitoring, Weight Change, BMI
- Trial name
- MCPILOTDSMES (NCT07556354)
- Testing
- Remote Patient Monitoring in a Faith-Based Program, Traditional Cohort Faith-based DSMES program
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Prediabetes
Trial of CGM Technology in Persons Living With Prediabetes
Continuous glucose monitor (CGM) technology has become increasingly prevalent in the population and has the ability to transform care of patients living with prediabetes.
- Trial name
- CGM (NCT07639593)
- Testing
- Stelo CGM
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences