Clinical trials: Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 2
An Investigational Drug Study in Patients With Type 2 Diabetes Mellitus (MK0431-023)
The purpose of this study is to determine the safety and effectiveness of an investigational drug in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT00094757
- Testing
- Comparator: sitagliptin 100 mg, Comparator: sitagliptin 200 mg, Comparator: pioglitazone
- Volunteers
- 521 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 1, Type 1 Diabetes
"FEXIS": (Feasibility of an Extended Wear CSII Set in Participants With T1DM)
Over 1 million patients globally currently manage their Type 1 Diabetes mellitus using continuous subcutaneous insulin infusion with an infusion set that needs to be changed every 3 days.
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Type 1 Diabetes Mellitus, Diabetes Mellitus, Insulin-Dependent, 1
- Trial name
- FEXIS (NCT04503564)
- Testing
- coil-reinforced soft polymer indwelling cannula
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Capillary Biomedical, Inc.
Diabetes
Study of an Investigational Glucose Meter System
The purpose of this study is to demonstrate that untrained subjects who have diabetes or pre-diabetes can operate the investigational Blood Glucose Monitoring System (BGMS) and obtain valid glucose results.
- Trial name
- NCT01466075
- Testing
- Apollo Evolution Investigational BG Monitoring System
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Ascensia Diabetes Care
Diabetes Mellitus, Type 2
A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes.
The study compares 2 medicines for people with type 2 diabetes: insulin 287 (a new medicine) and insulin glargine (a medicine doctors can already prescribe).
- Trial name
- NCT03751657
- Testing
- Insulin icodec, Metformin, Dipeptidyl peptidase-4 inhibitors
- Where
- 49 sites in United States, Canada and 5 more
- Volunteers
- 247 people
- Sponsor
- Novo Nordisk A/S
Diabetes
Evaluation of a Noninvasive Diabetes Screening Device in Subjects at Risk for Diabetes
The purpose of this research study is to test the safety and effectiveness of the SCOUT DS in measuring the concentration of substances (advanced glycation endproducts) in the skin.
- Trial name
- ENGINE (NCT01080157)
- Testing
- SCOUT DS measurement
- Where
- 12 sites in United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- VeraLight, Inc.
Type 2 Diabetes Mellitus
Phase 4: Investigational Study to Evaluate Metformin XR Monotherapy Versus Metformin IR Monotherapy in Subjects With Type 2 Diabetes
The purpose of this study is determine if Metformin XR monotherapy in subjects with type 2 diabetes is non-inferior to Metformin IR monotherapy
- Trial name
- NCT01864174
- Testing
- Metformin XR, Metformin IR
- Where
- 156 sites in United States, Canada and 8 more
- Volunteers
- 1,736 people
- Sponsor
- Bristol-Myers Squibb
Diabetes Mellitus, Type 2
Investigational Study of Delayed Release Metformin
In Phase 1 and 2 studies already conducted, Metformin DR, with its targeted delivery to the distal small intestine, has shown the potential to be a safe and effective way to improve glycemic control in patients with T2DM and CKD…
- Trial name
- DREAM-T2D (NCT04854512)
- Testing
- Metformin DR, Metformin IR
- Where
- 87 sites in United States, Brazil and 6 more
- Volunteers
- 675 people
- Sponsor
- Anji Pharma
Melanoma
Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)
Substudy 02B is part of a larger research study where researchers are looking for new ways to treat advanced melanoma that has not been treated before. The larger study is the umbrella study.
- Trial name
- NCT04305054
- Testing
- Pembrolizumab, Vibostolimab, Pembrolizumab/Quavonlimab
- Where
- 60 sites in United States, Argentina and 12 more
- Volunteers
- 335 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity Type 2 Diabetes Mellitus, Type 2 Diabetes Mellitus
An Investigational Drug Study to Assess Weight Loss in Patients With Type 2 Diabetes Mellitus (0364-011)(TERMINATED)
A worldwide study with extension in patients with type 2 diabetes mellitus to assess the safety and tolerability as well as the effects of treatment with an investigational drug for weight loss on body weight.
- Trial name
- NCT00430742
- Testing
- Taranabant
- Volunteers
- 600 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Treatment Use of Generex Oral-lyn™ in Patients With Diabetes
The objective of this Treatment IND protocol is to provide Generex Oral-lyn™ to patients with serious or life-threatening Type 1 or Type 2 diabetes mellitus, with no satisfactory alternative therapy available for treatment of…
- Trial name
- NCT00948493
- Testing
- Buccal insulin spray
- Sponsor
- Generex Biotechnology Corp.
Diabetes Mellitus, Type I, IDDM
SteadiSet™ Pilot Study (SteP Study)
This study will evaluate the safety and effectiveness of how well blood glucose is managed when a participate wears the investigational SteadiSet™ Infusion Set (SteadiSet device) for up to 14 days post-insertion when compared to…
- Conditions
- Diabetes Mellitus, Type I, IDDM, Diabetes Mellitus, Insulin-Dependent, 1, Type 1 Diabetes
- Trial name
- NCT04591925
- Testing
- Control Device insulin infusion devcie, Investigative insulin infusion devcie
- Where
- Austria
- Volunteers
- 13 people
- Sponsor
- Capillary Biomedical, Inc.
Diabetic Foot Ulcer (DFU)
A Study Comparing an Investigational Wound Gel With Standard Treatment for Mild to Moderate Diabetic Foot Ulcers
The goal of this clinical investigation is to evaluate if VES-0-D (an investigational wound gel) works to treat mild to moderate Diabetic Foot Ulcers.
- Trial name
- AIM-DFU (NCT07783087)
- Testing
- VES-0-D wound gel, Standard of Care (Investigator Choice)
- Where
- 8 sites in Belgium
- Volunteers
- 64 people
- Sponsor
- Flen Health
Diabetes
Evaluation of a Ascensia ONYX NEXT Investigational Blood Glucose Monitoring System
The purpose of this study was to determine if untrained subjects with diabetes and without diabetes could operate the Investigational Blood Glucose Monitoring System (BGMS) and obtain valid glucose results.
- Trial name
- NCT02390167
- Testing
- ONYX NEXT BGMS
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Ascensia Diabetes Care
Foot Ulcer, Diabetic
A Comparison of an Investigational Dressing to Tegaderm Matrix Wound Dressing in the Management of Diabetic Foot Ulcers
The primary objective is to: Assess the effect of the Non-adherent study dressing to 3M Tegaderm Matrix Dressing with PHI technology on wound healing in patients with a diabetic foot ulcer.
- Trial name
- NCT01013792
- Testing
- Wound Dressing
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Solventum US LLC
Type 2 Diabetes Mellitus
Phase 2 Study To Evaluate Safety And Efficacy Of Investigational Drug - PF04937319 In Patients With Type 2 Diabetes
B1621007 is designed to study the safety and efficacy of PF-04937319 in patients with type 2 diabetes
- Trial name
- NCT01475461
- Testing
- PF-04937319 - 3mg, PF-04937319 - 20mg, PF-04937319 - 50mg
- Where
- 63 sites in United States, Hungary and 6 more
- Volunteers
- 345 people
- Sponsor
- Pfizer
Diabetes
Evaluation of an Karajishi Contour Investigational Blood Glucose Monitoring System (ISO/FDA Study)
The purpose of this study was to determine if untrained persons with diabetes and without diabetes could operate the Investigational Blood Glucose Monitoring System (BGMS) and obtain valid blood glucose results.
- Trial name
- NCT02150109
- Testing
- Subjects WITH/WITHOUT Diabetes Use Karajishi Contour BGMS, Subjects WITH Diabetes Use Karajishi Contour BGMS
- Where
- 2 sites in United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Ascensia Diabetes Care
Diabetes
Performance of an Investigational Blood Glucose Monitoring System in a Clinical Setting
The purpose of this study is to evaluate the performance and acceptability of an investigational blood glucose monitoring system, which includes meter and sensor strip.
- Trial name
- NCT01268267
- Testing
- Ninja 2 Investigational Blood Glucose Monitoring System
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Ascensia Diabetes Care
Diabetes, Anemia
A Study to Compare Analytes in Blood Collected Using an Investigational Collection Device With a Commercial Predicate
This study will involve an investigational device, the Seventh Sense Biosystems TAP20-C. The TAP20-C device collects small amounts of blood from the forearm which can then be used for blood testing.
- Trial name
- NCT01786408
- Testing
- TAP20-C, SAFE-T-FILL CAPILLARY BLOOD COLLECTION SYSTEM
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seventh Sense Biosystems
Diabetes
Performance of an Investigational Blood Glucose Monitoring System in a Clinical Setting
The purpose of this study is to evaluate the performance of an investigational blood glucose meter with the Contour sensor strip.
- Trial name
- NCT01268488
- Testing
- Ninja 2 Investigational Blood Glucose Meter
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Ascensia Diabetes Care
Diabetes
Performance of an Investigational Blood Glucose Monitoring System
The purpose of this study was to demonstrate that untrained subjects who have diabetes can operate the Investigational Blood Glucose Monitoring System (BGMS) and obtain valid glucose results.
- Trial name
- NCT01824355
- Testing
- Ninja 3 PLUS Investigational BG Monitoring System
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Ascensia Diabetes Care