Clinical trials: Diabetes Mellitus II
Type II Diabetes Mellitus
Pharmacokinetics and Safety/Tolerability of CKD-379
A study to compare the pharmacokinetics and safety/tolerability between CKD-379 tablet and D759, D745, D150 combination
- Trial name
- NCT05719155
- Testing
- CKD-379, D759+D745+D150
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Type II Diabetes Mellitus
Study to Evaluate if Exposure to Drug is Impacted in Participants With Renal Insufficiency
This is an open-label, single-dose, Phase 1 clinical study designed to evaluate the effect of renal impairment on the pharmacokinetics (PK) of GL0034, a long-acting GLP-1 receptor agonist.
- Trial name
- NCT07385547
- Testing
- GL0034
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sun Pharmaceutical Industries Limited
Periodontal Diseases, Diabetes Mellitus
Anti Oxidant Enzymes and Total Antioxidant Levels in Diabetes Mellitus Type II Patients and Healthy Individuals With Periodontitis
To evaluate the role of antioxidants - superoxide dismutase, catalase, glutathione and total anti oxidant levels in the serum of chronic periodontitis patients and chronic periodontitis with DM Type II patients, then to compare…
- Conditions
- Periodontal Diseases, Diabetes Mellitus, Enzyme Disorder
- Trial name
- NCT04180332
- Testing
- Blood sample
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ajman University
Breast Density, Body Composition
Chilean Maternal & Infant Cohort Study II (CHiMINCs-II)
The Chilean Maternal \& Infant Cohort Study II (ChiMINCs II) is an ongoing cohort that is part of the Chilean Maternal and Infant Nutrition Observatory of the South-East area of Santiago, Chile.
- Conditions
- Breast Density, Body Composition, Nutritional Status, Mental Health Issue
- Trial name
- CHiMINCs-II (NCT03920098)
- Testing
- Nutrition and mental health during pregnancy
- Where
- Chile
- Volunteers
- 1,927 people, healthy volunteers welcome
- Sponsor
- Instituto de Nutrición y Tecnología de los Alimentos
Diabetes Mellitus, Type II
A Clinical Study to Compare the Pharmacokinetic Characteristics of CKD-395 0.25/750 mg in Healthy Male Volunteers
This study is a randomized, open-label, single dose, 2-way crossover study to compare the pharmacokinetic characteristics of CKD-395 0.25/750 mg in healthy male volunteers.
- Trial name
- NCT02627027
- Testing
- Duvie Tab. 0.5mg, Glucodaun OR Tab. 750mg, CKD-395 0.25/750mg
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Type II Diabetes Mellitus
Clinical Study to Compare the Pharmacokinetic Characteristics and Safety Between CKD-380 10mg and D308 10mg
This study is an open-label, randomized, fasted, single-dose, 2-way crossover study to compare the pharmacokinetic characteristics and safety between CKD-380 10mg and D308 10mg in healthy male adults.
- Trial name
- NCT03601910
- Testing
- D308 10mg Tab., CKD-380 10mg Tab.
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Type II Diabetes Mellitus
A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of Oral HMS5552 in Healthy Volunteers
The objectives of this study is to determine the safety profiles, tolerability, pharmacokinetics and pharmacodynamics of HMS5552 following single ascending doses in healthy adult subjects.
- Trial name
- NCT01952535
- Testing
- HMS5552
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hua Medicine Limited
Diabetes, Diabetes Mellitus, Type 2
Reducing Sedentary Behaviour in Patients With Type II Diabetes
The study will implement a prospective one-arm feasibility study. After an initial eligibility screening by the primary care provider during their intake appointment, new patients will be invited to participate in an acute…
- Conditions
- Diabetes, Diabetes Mellitus, Type 2, Sedentary Lifestyle
- Trial name
- NCT03815955
- Testing
- Non-Sedentary Behaviour Modelling
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Insulin Resistance, Diabetes
Effect of Endoplasmic Reticulum Stress on Metabolic Function
Normally, the hormone insulin works to help keep blood sugar normal. However, as a person gains weight, insulin does not work as well and blood sugar tends to be a little higher than normal. This is called "insulin resistance".
- Conditions
- Insulin Resistance, Diabetes, Obesity
- Trial name
- TUDCA/PBA (NCT00771901)
- Testing
- tauroursodeoxycholic acid, sodium phenylbutyrate
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Type 2, Healthy
Effect of Empagliflozin Kinetics on Renal Glucose Reabsorption in Patients With Type II Diabetes and Healthy Controls
Single center, 14-day, open-label trial to examine the effect of 25 mg q.d. empagliflozin on kinetics of renal glucose reabsorption in patients diagnosed with type 2 diabetes mellitus and healthy controls
- Trial name
- NCT01867307
- Testing
- Empagliflozin, BI 10773
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Type II Diabetes Mellitus
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01076829
- Testing
- Spice polyphenols
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus
Beta-2-Trace Protein in Diabetic Nephropathy
This cross-sectional study aims to evaluate serum beta-2-trace protein levels in patients with diabetic nephropathy compared with healthy controls.
- Trial name
- NCT07919795
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
GDM
A Co-created Self-care and Informal Support Intervention Study Among Women With GDM in Vietnam
Gestational Diabetes Mellitus (GDM) is significant public health problem in Vietnam, which is potentially treatable if managed properly by the pregnant women once diagnosed.
- Trial name
- VALID-II (NCT05744856)
- Testing
- Self-care with informal support
- Where
- 2 sites in Vietnam
- Volunteers
- 435 people, healthy volunteers welcome
- Sponsor
- Thai Binh University of Medicine and Pharmacy
Type II Diabetes Mellitus
Safety And Efficacy Of Empagliflozin In Pakistani Muslim Population With Type Ii Diabetes Mellitus
To compare the safety and efficacy of empagliflozin versus other treatments in Pakistani Muslim population with type II diabetes mellitus.
- Trial name
- SAFE-PAK (NCT04665284)
- Testing
- Empagliflozin, Usual care group
- Where
- 11 sites in Pakistan
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Getz Pharma
Diabetes Mellitus, Type II
Single Dose Escalation Study of PF-05190457 in Healthy Volunteers
PF-05190457 is a novel compound proposed for the treatment of Type 2 diabetes mellitus. The purpose of the study is to evaluate the safety and tolerability of PF-05190457 after administration of a single dose to healthy…
- Trial name
- NCT01247896
- Testing
- PF-05190457
- Where
- Belgium
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pfizer
Type II Diabetes
Role of Gastrointestinal Microbes on Digestion of Resistant Starch and Tryptophan Availability to Humans
There is currently a critical gap in knowledge of how intestinal bacterial communities alter metabolic substrates available to the host thereby influencing central and enteric nervous system (CNS/ENS) neurotransmitter levels…
- Trial name
- NCT02974699
- Testing
- Potato Starch (Bob's Red Mill), Pregelatinized Starch (Resource ThickenUp)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Intradermal Injections
A Pilot Study to Assess the Safety, PK and PD of Insulin Injected Via MicronJet or Conventional Needle
The purpose of this study is to compare glucose pharmacokinetics and insulin pharmacodynamics injected via the MicronJet in comparison with a conventional needle.
- Trial name
- MicronJet (NCT00602914)
- Testing
- MicronJet
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- NanoPass Technologies Ltd
Diabetes Mellitus, Type 2, Healthy Males
A First in Human, Single Dose, Safety and Tolerability Study of MKC253 Inhalation Powder in Healthy Adult Males
26 subjects will be enrolled into 5 different dose groups. The trial will consist of a screening, a dosing and a follow-up visit.
- Trial name
- NCT00475371
- Testing
- MKC253 Inhalation Powder
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation
Type 2 Diabetes Mellitus
Glycemic Control, Safety and Tolerability of TC-6987 Monotherapy in Type 2 Diabetes Mellitus
TC-6987 is a selective nicotinic α-7 receptor ligand (open channel stabilizer) that has demonstrated potent anti-inflammatory/antioxidant properties in animal models.
- Trial name
- NCT01293669
- Testing
- TC-6987
- Where
- 18 sites in United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Type 2 Diabetes
Can Enhanced Glycemic Control in Type II Diabetics Improve Myocardial Protection During Coronary Artery Bypass Grafting?
The investigators have previously demonstrated that the administration of insulin in the form of an infusion with additional sugar and potassium may improve cardiovascular performance and reduce biochemical evidence of heart…
- Trial name
- GUIDE (NCT00899483)
- Testing
- Glucose potassium insulin solution
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham