Clinical trials: Diabetes Mellitus II
Diabetes Mellitus, Type 2, Healthy
Effect of Empagliflozin Kinetics on Renal Glucose Reabsorption in Patients With Type II Diabetes and Healthy Controls
Single center, 14-day, open-label trial to examine the effect of 25 mg q.d. empagliflozin on kinetics of renal glucose reabsorption in patients diagnosed with type 2 diabetes mellitus and healthy controls
- Trial name
- NCT01867307
- Testing
- Empagliflozin, BI 10773
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus, Type 2
GALLEX 9: Safety and Tolerability of Oral Tesaglitazar When Added to Insulin Therapy in Patients With Type 2 Diabetes
This is a 140-week open-label, multi-center long-term extension study from GALLANT 9 to monitor the safety and tolerability of oral tesaglitazar 0.5 mg and insulin in patients with type 2 diabetes during up to 140 weeks of…
- Trial name
- NCT00229710
- Testing
- Tesaglitazar
- Where
- 69 sites in United States
- Volunteers
- 270 people
- Sponsor
- AstraZeneca
Pain, Diabetic Neuropathies
A Research Study of V3381 for the Treatment of Diabetic Peripheral Neuropathic Pain
The objective of this study is to investigate the safety and efficacy of an investigational drug, V3381, for the treatment of diabetic peripheral neuropathic (DPN) pain (pain in one's feet and legs, or even in one's hands and…
- Trial name
- NCT00375960
- Testing
- V3381
- Where
- 6 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- Vernalis (R&D) Ltd
Diabetes Mellitus, Type 2
mHealth Intervention to Support Diabetes Medication Adherence (Pilot Study)
This study aims at evaluating the feasibility of an intervention based on the use of a mobile-device based system delivering automated, tailored brief text messages to offer support for medicine use and lifestyle recommendations…
- Trial name
- DIABE-TEXT (NCT04738591)
- Testing
- DIABE-TEXT
- Where
- Spain
- Volunteers
- 207 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Heart Failure, Type II; Diabetes
Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects
The investigators propose a small pilot proof of concept study to not only prove the existence of, but also probe the mechanisms underlying cardio-renal effects of empagliflozin in patients with heart failure.
- Trial name
- EMPA (NCT03027960)
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Diabetes Mellitus
Study of Safety, Tolerability and Pharmacokinetics of Single Oral JTT-251 Doses in Healthy and Type 2 Diabetic Subjects
The purpose of this study is to evaluate the safety, tolerability, and PK (Pharmacokinetics) of single oral doses of JTT-251 in healthy and type 2 diabetes mellitus subjects and to evaluate the effect of food on the PK of JTT-251…
- Trial name
- NCT02106585
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shionogi Inc.
Diabetes Mellitus Progression, Diabetes Complications
Autologous Bone Marrow Transplant in Chronic Insulin Dependent Diabetic Patients
Diabetes, recently declared a pandemic by the World Health Organization, is a risk factor for increased mortality and morbidity.
- Trial name
- NCT03562208
- Testing
- Adult Bone Marrow Stem Cells
- Where
- The Bahamas
- Volunteers
- 100 people
- Sponsor
- Global Cell Med
Gestational Diabetes, Glucose Metabolism Disorders
Integrated Hyperglycaemia Incentivised Postnatal Surveillance Study (I-HIPS)
This study aims to test the following hypotheses in a randomized controlled trial of post-partum women with a history of gestational diabetes mellitus (GDM) that will be followed up for up to 4 years: 1.
- Conditions
- Gestational Diabetes, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- I-HIPS (NCT05081037)
- Testing
- Wearable Care Group
- Where
- Singapore
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Caries,Dental, Caries Root
Coronal and Radicular Caries Prevalence and Related Risk Factor in Diabetic Patient
This study aims to investigate the prevalence and risk factors of coronal and radicular caries in middle-aged individuals with Type 2 diabetes.
- Conditions
- Caries,Dental, Caries Root, Diabetes Mellitus, Type 2
- Trial name
- NCT06701565
- Volunteers
- 265 people
- Sponsor
- Cairo University
Resistant Hypertension, NIDDM
Resistant Hypertension in Patients With Type-II-Diabetes Mellitus
The risk of cardiovascular disease (CVD) in patients with type-II-diabetes mellitus (type-II-DM)is more than doubled and CVD accounts for 70% of deaths in this group of patients.
- Trial name
- RESIST (NCT01056367)
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Svendborg Hospital
Nonalcoholic Steatohepatitis
Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitis
The purpose of this study is to investigate whether 48 weeks treatment with once-daily injections of liraglutide improves liver disease (liver fat, inflammation and scarring) and related metabolic parameters in overweight…
- Trial name
- LEAN (NCT01237119)
- Testing
- Liraglutide
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Birmingham
Diabetes Mellitus Type 2
HOPE Intervention for Fitness
We will test the HOPE intervention on changing behavior of people to exercise more (take more steps each day).
- Trial name
- NCT07114822
- Testing
- Harnessing Online Peer Education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Impaired Glucose Tolerance
HSK7653 in Chinese Patients with Impaired Glucose Tolerance
This study is being done to evaluate the efficacy, safety of HSK7653 in chinese participants with impaired glucose tolerance.
- Trial name
- NCT04727580
- Testing
- HSK7653 10mg Q2W, HSK7653 25mg Q2W
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Obesity, Diabetes Mellitus, Type 2
Systemic Metabolic Rate of Diabetic Patients Before and After Bariatric Gastric Bypass Using the Breezing® Device.
To evaluate the systemic metabolic rate of diabetic patients before and after bariatric gastric bypass surgery using the Breezing® device.
- Trial name
- NCT05505773
- Volunteers
- 200 people
- Sponsor
- Kaiser Clinic and Hospital
Chronic Kidney Disease, Type II Diabetes
Heart-Kidney-Diabetes Multidisciplinary Care MOdels for CardiovascuLar Health In Patients With Chronic Kidney DiSease and Diabetes: A PragmaTIC Cluster Randomized Controlled Trial (HOLISTIC)
Our overarching goal of this study is to provide rigorous evidence for using an accelerated risk-based approach to implementing guideline directed medical therapies (GDMT) using a multidisciplinary care model (MCM) versus a usual…
- Trial name
- HOLISTIC (NCT07811427)
- Testing
- The intervention with the MCM is Kidney-Heart GDMT initiation and titration for dose optimization (as clinically tolerated), within 4 months of enrollment in the study.
- Volunteers
- 570 people
- Sponsor
- Baim Institute for Clinical Research
Diabetes Mellitus, Type 1
Extension of Phase II Therapeutic Trial With a Humanized Non-Mitogenic CD3 (ChAgly CD3) Monoclonal Antibody in Recently Diagnosed Type 1 Diabetic Patients
Compared to placebo, treatment with ChAgly CD3 has a beneficial effect on preservation of beta cell function and metabolic outcome in type 1 diabetic patients with recent clinical onset of disease that persists until 48 months…
- Trial name
- NCT00627146
- Testing
- ChAgly CD3
- Where
- 5 sites in Belgium, Germany
- Volunteers
- 80 people
- Sponsor
- Universitair Ziekenhuis Brussel
Type II Diabetes Mellitus
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01076829
- Testing
- Spice polyphenols
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes
Improving Risk Factors for Diabetes Complications in Primary Care
The purpose of this study is to test an intervention in primary care clinics to improve three risk factors for diabetes complications: glucose control, blood pressure and cholesterol.
- Trial name
- NCT00482768
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 2,493 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabetes Mellitus, Type II
Investigate the Effect of Food on the Pharmacokinetic Characteristics of CKD-395 in Healthy Male Volunteers
This study is A randomized, open-label, single dose, 2-way crossover study to investigate the effect of food on the pharmacokinetic characteristics of CKD-395 in healthy male volunteers.
- Trial name
- NCT02648854
- Testing
- CKD-395 0.5(Lobeglitazone)/1000(Metformin)mg 1T
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Type 1 Diabetes Mellitus, Type 1 Diabetes
PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
The purpose of this study is to establish the safety and efficacy of multiple administrations of PROCHYMAL® in participants recently diagnosed with type 1 diabetes mellitus.
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Insulin-Dependent, Juvenile Diabetes
- Trial name
- NCT00690066
- Testing
- PROCHYMAL®
- Where
- 20 sites in United States
- Volunteers
- 63 people
- Sponsor
- Mesoblast, Inc.