Clinical trials: Diabetes Mellitus Risk
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University
Gestational Diabetes, Pregnancy Complications
Healthy Eating in Women at Risk of Gestational Diabetes
Healthy eating during pregnancy has favorable effects on markers related to diabetes (glucose tolerance) and is associated with lower gestational diabetes mellitus (GDM) risk.
- Trial name
- SAGE (NCT05299502)
- Testing
- Nutritional Intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Diet, Healthy, Health Behavior
A Food As Medicine Approach to Address Food Insecurity in Rural North Carolina
Increasing fruit and vegetable (FV) intake, and reducing saturated fat, salt, and added sugar are central lifestyle recommendations in the Dietary Guidelines for Americans to prevent chronic disease.
- Conditions
- Diet, Healthy, Health Behavior, Blood Pressure, Diabetes Mellitus Risk
- Trial name
- NCT07221045
- Testing
- PhytoRx Families: A Pilot Test to Address Food Security in Rural North Carolina
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Hypertension, Dyslipidemia
Polypills Approach for Multiple Cardiovascular Risk Factors
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated…
- Conditions
- Hypertension, Dyslipidemia, Diabetes
- Trial name
- PACIF (NCT07679828)
- Testing
- Fixed-Dose Combination Strategy
- Where
- 15 sites in China
- Volunteers
- 8,252 people
- Sponsor
- China Medical University, China
Type 2 Diabetes, Cardiovascular Diseases
The Impact of Consumption of Eggs in the Context of Plant-Based Diets on Endothelial Function, Diet Quality, and Cardio-Metabolic Risk Factors in Adults at Risk for Type 2 Diabetes
Purpose To assess the impact of inclusion of 2 eggs daily for 6 weeks in an otherwise vegan diet compared to a vegan diet on cardio-metabolic risk and dietary pattern in adults at risk for type 2 diabetes.
- Trial name
- NCT04316429
- Testing
- Egg included vegan phase, Vegan Phase
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Griffin Hospital
Diabetes Type 2, Type II Diabetes Mellitus
Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors
This project aims to adapt, implement, and evaluate PLA based intervention in Rural Kabul, Afghanistan for TIIDM prevention and control.
- Trial name
- EMPOWER-D-Afg (NCT07350694)
- Testing
- PLA
- Where
- Afghanistan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- HealthNet Transcultural Psychosocial Organization
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Network-based Approach in Type 2 Diabetes and Its Cardiovascular Risk
PIRAMIDE study design will test the hypothesis that simultaneous interactions between DNA methylation and microRNAs may hit T2D candidate genes and predict the development of T2D-related cardiovascular complications.
- Trial name
- PIRAMIDE (NCT03792607)
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Giuditta Benincasa
Pregnancy Complications, Diabetes Mellitus
Correlation of CGM Metrics With OGTT and Pregnancy Outcomes in Pregnant Women With or Without a High Risk for GDM
the aim of the study is to obtain CGM data concomitant with OGTT and to determine what CGM metrics obtained in pregnant women with and without a high risk of GDM correlate best with the diagnostic OGTT (obtained via the 2-step…
- Conditions
- Pregnancy Complications, Diabetes Mellitus, Hyperglycemic Disorder
- Trial name
- NCT05537480
- Testing
- Continuous glucose monitoring device
- Where
- Israel
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Type 2 Diabetes, Cardiovascular Risk Factor
Effects of empagliFlozin on myocardIal metabOlic Rate of glucosE Estimated Through 18FDG PET (FIORE Study)
Diabetes is an independent risk factor for ischemic heart disease (CAD) and heart failure, and cardiovascular diseases are the main cause of mortality and morbidity in patients with diabetes.
- Trial name
- FIORE (NCT04183868)
- Testing
- Empagliflozin 10 MG, Glimepiride 2 mg
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Catanzaro
Type 2 Diabetes Mellitus
The Effect of Resistant Starch Bagels on Risk Factors of Type 2 Diabetes and Colorectal Cancer
The purpose of this study is to determine if consumption of bagels made with resistant starch for 8 weeks can improve markers of type 2 diabetes, colon cancer and satiety in adults.
- Trial name
- NCT02129946
- Testing
- Resistant Starch
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Overweight and Obesity, Risk Reduction
Healthy Lifestyle Intervention on Diabetes Risk Reduction Among Bruneian Young Adults
The general research question posed was 'How effective is a healthy lifestyle intervention using behavioural change strategies in the prevention of Type 2 Diabetes Mellitus (T2DM)?'.
- Conditions
- Overweight and Obesity, Risk Reduction, Diabetes Mellitus, Type 2
- Trial name
- NCT04217759
- Testing
- Healthy lifestyle intervention
- Where
- Brunei
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Universiti Brunei Darussalam
Hypertension, Diabetes Mellitus Type 2
County Medical Community-based, Cardiovascular Risk Stratified Integrated Care Model: a Pragmatic Cluster Randomised Control Trial
The goal of this cluster randomized trial is to evaluate the effectiveness of the RISIMA model based on an integrated county healthcare consortium implemented by multi-level family health teams (FHTs)on patients with diabetes…
- Conditions
- Hypertension, Diabetes Mellitus Type 2, Cardiovascular Diseases
- Trial name
- C-RISIMA (NCT06302127)
- Testing
- Team-based care, Risk-stratified care pathway, Strengthened health education
- Where
- 3 sites in China
- Volunteers
- 2,560 people
- Sponsor
- Peking University
Diabetes, Cardiovascular Risk
The Effects of Soy Protein and Isoflavones on Glycemic Control, Insulin Sensitivity and Cardiovascular Risk Factors
The investigators propose to perform a double-blind, randomized placebo-controlled trial to examine the hypothesis that soy protein with isoflavones could improve glycemic control, insulin sensitivity and decrease cardiovascular…
- Trial name
- NCT00856882
- Testing
- soy protein, isoflavones, milk protein
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
Risk Model of Cognitive Impairment in Diabetes
Development and validation of a risk model for predicting the risk of mild cognitive impairment among individuals of type 2 diabetes.
- Trial name
- NCT05590442
- Testing
- Tests
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cardiovascular Disease Prevention, Cardiometabolic Diseases
Preventative Screening and Health Coaching in a Food Insecure Population
The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food insecure population.
- Conditions
- Cardiovascular Disease Prevention, Cardiometabolic Diseases, Cardiovascular Risk Factor, Cardiovascular Risk Score
- Trial name
- HEALTHCOACH (NCT06907524)
- Testing
- Longitudinal, Individualized Health Coaching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Overweight, Prediabetic State
A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-related conditions, including type 2 diabetes, hypertension, and…
- Conditions
- Overweight, Prediabetic State, Prehypertension, Obesity, Abdominal
- Trial name
- ATTAIN-NOW (NCT07794579)
- Testing
- Orforglipron
- Where
- 180 sites in United States, Argentina and 10 more
- Volunteers
- 2,001 people
- Sponsor
- Eli Lilly and Company
Lung Cancer, Nonsmall Cell, Renal Cell Carcinoma
Risk Factors of Immune-ChEckpoint Inhibitors MEdiated Liver, Gastrointestinal, Endocrine and Skin Toxicity
"Risk factors of Immune-ChEckpoint inhibitor MEdiated Liver, gastrointestinal, endocrine and skin Toxicity" (ICEMELT) study is a prospective multicenter cohort study, enrolling patients who are scheduled to receive (1) single…
- Conditions
- Lung Cancer, Nonsmall Cell, Renal Cell Carcinoma, Melanoma, Gastric Cancer
- Trial name
- ICEMELT (NCT04631731)
- Testing
- Blood screening, Tissue screening
- Where
- 2 sites in Australia
- Volunteers
- 200 people
- Sponsor
- Western Sydney Local Health District
Chronic Kidney Disease
Risk Factors for Foot Ulceration in the Chronic Kidney Disease (CKD) Population
Foot ulceration is a risk factor that has been associated with early death in patients with chronic kidney disease. Little is known about the relationship between these risk factors that develop in patients with kidney failure…
- Trial name
- NCT01089829
- Testing
- Foot examination
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Cardiff University
Diabetic Retinopathy, Diabetic Macular Edema
Predicting Diabetic Retinopathy From Risk Factor Data and Digital Retinal Images
The objective of this study is to compare the results of a deep learning approach to diabetic retinopathy assessment with results from (1) an in-person examination with an ophthalmologist, and (2) the assessments of optometrists…
- Trial name
- NCT03694145
- Testing
- In-Person Eye Examination
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Charles Drew University of Medicine and Science
Prediabetes
Prospective Follow-up of a Cohort of Pre-diabetics in the North of France (DiabeNord)
The purpose of this study is to identify in prediabetic subjects, physiopathological changes involved in the evolution to type 2 diabetes mellitus and to identify new biomarkers of type 2 diabetes risk in this population.
- Trial name
- DiabeNord (NCT01432509)
- Testing
- Prediabetes screening and prospective follow-up over 5 years
- Where
- France
- Volunteers
- 207 people
- Sponsor
- Nantes University Hospital
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