Clinical trials: Diabetes Mellitus Type 2 (T2DM)
Diabetes Mellitus, Type 2
Canagliflozin (Invokana™) vs. Standard Dual Therapy Regimen for T2DM During Ramadan
This study aims to determine if the addition of Canagliflozin (Invokana™) therapy to monotherapy of metformin is more effective at achieving the double composite endpoint of a reduction in HbA1c (≥ 0.3%) and weight loss (≥1kg)…
- Trial name
- Can Do (NCT02694263)
- Testing
- Canagliflozin, Repaglinide, Pioglitazone
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Leicester
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCL 25mg/5mg/1000mg Extended-Release Tablets Versus Trijardy® XR Extended Release Film Coated Tablets
Randomized, Single Oral Dose, Two-period, Two Sequence, Open-label, Crossover, Bioequivalence Study to Compare Empagliflozin-Linagliptin-Metformin XR Tablet 25mg/ 5mg/1000mg (25mg Empagliflozin /5mg Linagliptin /1000mgMetformin…
- Trial name
- NCT07213895
- Testing
- Empagliflozin/Linagliptin/Metformin HCL, Trijardy® XR Extended release film coated tablets
- Where
- Jordan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Type 2 Diabetes Mellitus (T2DM), Food Effect
Food Effect, Efficacy and Safety of MKP10241 in Healthy and Obese Adult Participants, With and Without Diabetes
The goal of this intervention study is to evaluate the safety, tolerability and pharmacokinetics (PK) and pharmacodynamics (PD) of multiple doses of MKP10241 in obese participants with and without T2DM in 3 parts.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Food Effect, Safety and Tolerability, Obesity
- Trial name
- NCT07098663
- Testing
- MKP10241
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Mankind Pharma Limited
T2DM (Type 2 Diabetes Mellitus)
The Efficacy and Safety of DWP16001 in Combination With Metformin in Patients With Type 2 Diabetes.
Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of DWP16001 in Combination with Metformin in Patients With Type 2 Diabetes Mellitus who Have Inadequate Glycemic Control on Metformin Alone.
- Trial name
- ENHANCE-M (NCT04634500)
- Testing
- Dapagliflozin
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Type 2 Diabetes, Obesity
Canola-Mediterranean Diet Study in T2DM
The purpose of the study is to assess whether a Mediterranean-type weight-loss diet, enriched with canola oil, high in plant protein, and low in carbohydrates will produce blood sugar control, reduce coronary heart disease (CHD)…
- Conditions
- Type 2 Diabetes, Obesity, Overweight, Cardiovascular Diseases
- Trial name
- NCT02245399
- Testing
- A canola oil enriched mediterranean diet, A high wheat fiber diet
- Where
- 3 sites in Canada
- Volunteers
- 164 people
- Sponsor
- Unity Health Toronto
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Community-Empowerment and Environmental Enrichment-based Co-management (CEEEC) Model and Mechanisms for Improving Health of Older Stroke Patients With Multimorbidity
This study is a cluster randomized controlled trial with a 2×2 factorial design conducted in community health centers in Kunshan, Wuhan and Shanghai, China.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Multimorbidity, Stroke
- Trial name
- CEEEC (NCT06975501)
- Testing
- Exercise Intervention, Cognitive Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Duke Kunshan University
Obesity, Type 2 Diabetes Mellitus (T2DM)
MagDI Italian Study
The objective of the MagDI Italy Study is to evaluate the feasibility / performance, safety, and initial efficacy of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side…
- Conditions
- Obesity, Type 2 Diabetes Mellitus (T2DM), Anastomosis
- Trial name
- NCT06613711
- Testing
- Magnet System, DI Biofragmentable
- Where
- 4 sites in Italy
- Volunteers
- 27 people
- Sponsor
- GT Metabolic Solutions, Inc.
Type 2 Diabetes (T2DM), Geriatric Syndromes
Using Virtual Reality to Improve Medical Training
As the U.S. population ages, future physicians must be prepared to care for older adults with multiple health conditions and complex needs.
- Conditions
- Type 2 Diabetes (T2DM), Geriatric Syndromes, Disability Hearing, Disability Physical
- Trial name
- NCT07542834
- Testing
- Cinematic Virtual Reality Training, Traditional Didactic Lecture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio University
Obesity, Overweight
A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or Overweight, With or Without Type 2 Diabetes
The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA) being developed for chronic weight…
- Conditions
- Obesity, Overweight, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT07670416
- Testing
- Enicepatide
- Where
- 21 sites in China
- Volunteers
- 300 people
- Sponsor
- Hoffmann-La Roche
Type 2 Diabetes Mellitus
Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus
In this randomized, double-blind, double-dummy, placebo-controlled study, approximately 675 eligible subjects with type 2 diabetes and inadequate control on at least one and up to 3 oral glucose-lowering agents will undergo an…
- Trial name
- NCT04606576
- Testing
- ORMD-0801 QD, ORMD-0801 BD
- Where
- United States
- Volunteers
- 710 people
- Sponsor
- Oramed, Ltd.
Type 2 Diabetes Mellitus (T2DM)
Clinical Study to Evaluate the Food Effect of CKD-378 in Healthy Volunteers
This study is a randomized, open-label, single dose, crossover study to evaluate the food effect of CKD-378 in healthy volunteers
- Trial name
- NCT06709807
- Testing
- CKD-378 25/1000mg
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Type 2 Diabetes Mellitus (T2DM), Atrial Fibrillation (AF)
Strict Weight Management Based on GLP-1 RA for Ablation Outcomes in Overweight or Obese Patients with T2DM and AF
Objective To compare, in patients with Type 2 Diabetes Mellitus (T2DM) and Atrial Fibrillation (AF) undergoing radiofrequency ablation (RFA), whether strict weight management and glycemic control based on Glucagon-like Peptide-1…
- Trial name
- NCT06660134
- Testing
- Glucagon-like peptide-1 receptor agonists (GLP 1 RA)
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Shanghai Chest Hospital
Type2diabetes
Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh
The study titled "Efficacy and Safety of Omarigliptin, A Weekly Dipeptidyl Peptidase-4 Inhibitor for Type 2 Diabetes Management: Real-World Evaluation in Bangladesh" aims to assess the real-world effectiveness and safety of…
- Trial name
- NCT06449235
- Testing
- Omarigliptin, Sulphonylureas, Metformin
- Where
- Bangladesh
- Volunteers
- 938 people
- Sponsor
- Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders
Type 2 Diabetes Mellitus (T2DM), Vitamin D Deficiency
Effect of Vitamin D Supplementation on Metabolic Parameters in Patients With Type 2 Diabetes and Vitamin D Deficiency
The goal of this clinical study is to learn whether vitamin D supplementation improves metabolic control in adults with type 2 diabetes mellitus who have vitamin D deficiency.
- Trial name
- VITD-DM2 (NCT07468721)
- Testing
- cholecalciferol (vitamin D3)
- Where
- Paraguay
- Volunteers
- 119 people
- Sponsor
- Faculty of Medical Sciences, Clinical Hospital
Type 2 Diabetes (T2DM)
Impact of a Nutritional Intervention Based on Moroccan Dietary Habits on the Glycemic Control of Type 2 Diabetics
The goal of this study is to learn if a nutritional intervention adapted to Moroccan dietary habits can improve blood sugar control in adults with Type 2 Diabetes.
- Trial name
- NCT07404280
- Testing
- Moroccan-Adapted Nutritional Plan
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Type 2 Diabetes (T2DM)
A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia
This trial is conducted in Indonesia. The aim of the trial is to evaluate the efficacy and safety of BGM0504 versus semaglutide as add-on to metformin in patients with type 2 diabetes
- Trial name
- NCT07064486
- Testing
- BGM0504, Semaglutide
- Where
- 4 sites in Indonesia
- Volunteers
- 152 people
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
Type 2 Diabetes Mellitus, Iron Deficiency
Ferric Carboxymaltose in Type 2 Diabetes Mellitus (T2DM) Patients With Iron Deficiency
The purpose of this study is to investigate the correlation between HbA1c and iron status in Type 2 Diabetes mellitus patients with iron deficiency by intravenous substitution of iron.
- Trial name
- CLEVER (NCT01513369)
- Testing
- ferric carboxymaltose, NaCl (0,9%)
- Where
- 6 sites in Germany
- Volunteers
- 152 people
- Sponsor
- GWT-TUD GmbH
Type 2 Diabetes
Efficacy and Safety of Saxagliptin VS. Glimepiride in Chinese T2DM Patients Controlled Inadequately With Metformin
This is a multi-centre, open-label, randomized, parallel trial to investigate the efficacy and safety profile of saxagliptin and glimepiride treatment in patients with type 2 diabetes inadequately controlled with metformin…
- Trial name
- SPECIFY (NCT02280486)
- Testing
- Saxagliptin, Glimepiride
- Where
- China
- Volunteers
- 388 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Type 2 Diabetes Mellitus
Efficacy and Safety of Combination Therapy of Vildagliptin/Metformin in Patients in Type 2 Diabetes Mellitus (T2DM)
This study will assess the efficacy and safety of combination therapy of vildagliptin/metformin in patients with T2DM inadequately controlled with metformin 1,000 mg/day.
- Trial name
- NCT01196546
- Testing
- vildagliptin/metformin
- Where
- 8 sites in Thailand
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Novartis
Angina Pectoris, Coronary Artery Disease
A Study on the Effects of Ranolazine on Exercise Duration in Subjects With Chronic Stable Angina and Coronary Artery Disease (CAD) With Type 2 Diabetes Mellitus (T2DM)
This study will evaluate the efficacy of ranolazine compared to placebo on duration of exercise assessed by exercise tolerance testing (ETT) at anticipated peak ranolazine plasma concentration after 12 weeks of treatment in…
- Conditions
- Angina Pectoris, Coronary Artery Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT01334203
- Testing
- Ranolazine
- Sponsor
- Gilead Sciences