Clinical trials: Diabetes Related Complications
Diabetic Retinopathy
Evaluation of Progression of Diabetic Retinopathy With Rapid Correction of Hyperglycemia
The investigators are doing this research for two reasons. The first is to see how the retina (back of your eye) changes when your blood sugar is treated with medication for the first time.
- Trial name
- NCT02326259
- Testing
- Initiation of treatment of diabetes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Pseudophakic Macular Edema, Diabetic Nephropathies
Diabetic Nephropathy, Glycemic Control and Pseudophakic Macular Edema After Cataract Surgery
This retrospective cohort study examines whether the kidney complications of diabetes (diabetic nephropathy) and blood-sugar control before surgery help predict swelling of the central retina, called pseudophakic macular edema…
- Conditions
- Pseudophakic Macular Edema, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Cataract (Post-operative Cataract Surgery Follow-up)
- Trial name
- NCT07723846
- Testing
- Phacoemulsification with posterior-chamber IOL
- Where
- Thailand
- Volunteers
- 428 people
- Sponsor
- Thammasat University Hospital
Diabetic Retinopathy
Blood Factors and Diabetic Retinopathy
This study will determine whether certain factors in the blood are associated with the severity of diabetic retinopathy. Patients age 10 years and older with diabetes mellitus and diabetic retinopathy may be eligible for this…
- Trial name
- NCT00005761
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Nephropathies
PERL Continuous Glucose Monitoring (CGM) Study
Seven-point capillary profiles have shown that mean glucose correlates with both diabetic retinopathy and nephropathy risk. However, there remains great controversy as to whether the degree of variability around mean glucose may…
- Trial name
- NCT03334318
- Testing
- Mean blood glucose, Blood glucose CV, % time 70-180 mg/dL
- Where
- 19 sites in United States, Canada
- Volunteers
- 175 people
- Sponsor
- Joslin Diabetes Center
Diabetic Foot, Ulcer Foot
Diabetic Foot Ulcer Recurrence: Pilot Study
In this prospective pilot study, patients with DFU visiting the Indiana University Comprehensive Wound Center will be enrolled. Patients enrolled in the study will be followed for 16 weeks for wound closure(Phase A), and will…
- Trial name
- DFUCO (NCT03479242)
- Testing
- no interventions
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
Efficacy of Trimetazidine in Diabetic Patients
Subclinical diastolic dysfunction represents the early phase of diabetic cardiomyopathy and is a common complication among type 2 diabetic patients that increases mortality rate among those patients and can progress to heart…
- Trial name
- NCT05556005
- Testing
- Trimetazidine Dihydrochloride
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Diabetic Foot Ulcer
Efficacy of LL-37 Cream on Bacteria Colonization, Inflammation Response and Healing Rate of Diabetic Foot Ulcers
Diabetic foot ulcer (DFU) is a common complication of diabetes with global prevalence of 6.3%. Treatment of diabetic foot ulcer (DFU) is challenging with disappointing outcome.
- Trial name
- NCT04098562
- Testing
- LL37, Standard Wound Care
- Where
- 3 sites in Indonesia
- Volunteers
- 40 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Diabetic Polyneuropathy
Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy
Painful diabetic neuropathy is the most common cause of neuropathic pain. 0.075% topical capsaicin has been used to treat the pain, but there is no data in lower concentration.
- Trial name
- NCT00993070
- Testing
- Capsaicin
- Where
- Thailand
- Volunteers
- 33 people
- Sponsor
- Thammasat University
Diabetic Retinopathy
High Blood Pressure and Sleep Apnea in Diabetic Macular Edema
Macular edema remains a major cause of vision impairment in diabetic patients. Its pathogenesis is multifactorial and incompletely understood.
- Trial name
- OMHADIA (NCT00970723)
- Testing
- high blood pressure treatment, sleep apnea treatment, diabetic macular edema treatment
- Where
- 5 sites in France
- Volunteers
- 86 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Retinopathy, Diabetic Macular Edema
Bangladesh PRODUCTIVity in Eyecare Trial
The purpose of this study is to assess the impact of using autonomous artificial intelligence (AI) system for identification of diabetic retinopathy (DR) and diabetic macular edema on productivity of retina specialists in…
- Trial name
- B-PRODUCTIVE (NCT05182580)
- Testing
- Results utilized from autonomous AI diagnostic system for diabetic retinopathy and/or diabetic macular edema
- Where
- Bangladesh
- Volunteers
- 993 people, healthy volunteers welcome
- Sponsor
- Orbis
Age - Related Macular Degeneration (AMD), Diabetic Macular Edema
Wide Field OCTA in Ocular Diseases
The main retinal diseases, whether or not associated with specific mutations genetic, cause progressive degeneration of vascular retinal structures and not vascular, resulting in decreased visual function.
- Conditions
- Age - Related Macular Degeneration (AMD), Diabetic Macular Edema, Diabetic Retinopathy, Myopia
- Trial name
- WOOD-2025 (NCT07298174)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diabetic Retinopathy, Blindness
Diabetic Retinopathy Study (DRS)
To determine whether photocoagulation helps prevent severe visual loss from proliferative diabetic retinopathy. To determine whether a difference exists in the efficacy and safety of argon versus xenon photocoagulation for…
- Trial name
- NCT00000160
- Testing
- Xenon Photocoagulation, Argon Photocoagulation, Photocoagulation
- Sponsor
- National Eye Institute (NEI)
Diabetes Mellitus, Diabetes Mellitus Complications
Safety and Efficacy of Relamorelin Administered to Participants With Vomiting Symptoms and Moderate to Severe Diabetic Gastroparesis
The purpose of this study is to evaluate the effects of multiple dose regimens of relamorelin on vomiting episodes, gastric emptying and gastroparesis symptoms in participants with Type 1 and Type 2 diabetes mellitus and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus Complications, Gastroparesis
- Trial name
- NCT02357420
- Testing
- Relamorelin
- Where
- 98 sites in United States, Belgium and 5 more
- Volunteers
- 393 people
- Sponsor
- Allergan
Autosomal Dominant Polycystic Kidney Disease (ADPKD), Advanced-Chronic Kidney Disease (CKD)
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Kidney Diseases
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects suffering from chronic kidney disease and from healthy volunteers.
- Conditions
- Autosomal Dominant Polycystic Kidney Disease (ADPKD), Advanced-Chronic Kidney Disease (CKD), Diabetic Kidney Disease (DKD), IgA Nephropathy (IgAN)
- Trial name
- BIOMIS-Nefro (NCT04689074)
- Testing
- Biological sample collection, Questionnaire, Medical examination
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy
Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment
Vitreoretinal surgery for epiretinal proliferation tractional retinal detachment associated with proliferative diabetic retinopathy (PDR) is often complicated by hemorrhage from fibrovascular tissue.
- Conditions
- Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy, Tractional Retinal Detachment, Diabetic Retinopathy
- Trial name
- NCT00548197
- Testing
- Bevacizumab
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Iran University of Medical Sciences
Diabetic Retinopathy, Retinal Diseases
Intravitreal Ranibizumab Combined With Panretinal Photocoagulation in Patients With Proliferative Diabetic Retinopathy
To evaluate the efficacy of combination therapy with ranibizumab (RBZ) and panretinal photocoagulation (PRP) versus PRP alone in patients with treatment-naive bilateral proliferative diabetic retinopathy (PDR) as measured by mean…
- Conditions
- Diabetic Retinopathy, Retinal Diseases, Eye Diseases, Diabetic Angiopathies
- Trial name
- NCT01746563
- Testing
- Ranibizumab, Laser therapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Diabetic Retinopathy
A Study That Uses Data From Routine Eye Examinations of Patients Participating in Studies FIDELIO-DKD and FIGARO-DKD to Explore Whether Finerenone Can Delay the Progression of a Diabetes Complication That Affects the Eyes (Diabetic Retinopathy ,DR)
Diabetic retinopathy (DR) is a diabetes complication caused by damage to the small blood vessels inside the retina at the back of the eye. Diabetic retinopathy may cause mild vision problems or eventually blindness.
- Trial name
- ReFineDR (NCT04477707)
- Testing
- Finerenone (BAY94-8862)
- Where
- 62 sites in United States, Argentina and 13 more
- Volunteers
- 206 people
- Sponsor
- Bayer
Diabetic Macular Edema (DME), Age-Related Macular Degeneration (AMD)
Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections
This Phase 4, multicenter, randomized, double-masked clinical study evaluates the efficacy and safety of chloroprocaine hydrochloride ophthalmic gel 3% (IHEEZO) compared with routine anesthesia (topical proparacaine 0.5% combined…
- Conditions
- Diabetic Macular Edema (DME), Age-Related Macular Degeneration (AMD), Retinal Vein Occlusion, Diabetic Retinopathy (DR)
- Trial name
- Quell (NCT07456826)
- Testing
- Chloroprocaine Ophthalmic Gel 3% (IHEEZO), Proparacaine Hydrochloride Ophthalmic Solution 0.5%, Lidocaine Hydrochloride Injection 2%
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Harrow Inc
Diabetic Foot Ulcer, Diabetic Neuropathy Peripheral
Patients With Diabetic Neuropathy Who Receive Physiotherapy Treatment Will Have a Decrease in Diabetic Foot Ulcers
This study evaluates the effects of a physiotherapy protocol (manual therapy and exercise) in the prevention of diabetic foot ulcers in patients with diabetic neuropathy.
- Trial name
- NCT03725917
- Testing
- Physiotherapy protocol
- Where
- Spain
- Volunteers
- 143 people
- Sponsor
- Universidad Complutense de Madrid
Hyperuricemia, Diabetic Nephropathies
Hyperuricemia and Diabetic Nephropathy
The purpose of the study is to detect the effect of treatment of hyperuricemia on eGFR (Estimated Glomerular Filtration Rate) as an objective criterion for assessment of progression of diabetic nephropathy in patients with Type 2…
- Trial name
- NCT04799925
- Testing
- Febuxostat
- Volunteers
- 200 people
- Sponsor
- Assiut University
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