Clinical trials: Diabetes Treatment (Pilot Study)
Diabetic Macular Edema
A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema
The objective of this study is to investigate the safety and efficacy of minocycline as a microglia inhibitor in individuals with diabetic macular edema (DME).
- Trial name
- NCT01120899
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Type 2 Diabetes
"Information Technology Methodology for Patient Motivation in Diabetes Management."
Type 2 diabetes is a chronic metabolic disorder requiring lifestyle modification and medicines, adherence to which has to be practised on a daily basis.
- Trial name
- NCT00727896
- Testing
- Pre-coded messages, Diabetes Treatment
- Where
- India
- Volunteers
- 200 people
- Sponsor
- India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
Adherence, Medication
Feasibility and Acceptability of a Complex Intervention to Improve Initial Medication Adherence
This pilot study aims to test the feasibility of the following effectiveness and cost-effectiveness evaluation using Real-World Data.
- Trial name
- NCT05094986
- Testing
- Initial Medication Adherence (IMA) Intervention, Usual Care
- Where
- 5 sites in Spain
- Volunteers
- 605 people
- Sponsor
- Fundació Sant Joan de Déu
Diabetic Retinopathy
Long-term Retinal Changes After Topical Citicoline Administration in Patients With Mild Signs of Diabetic Retinopathy in Type 1 Diabetes Mellitus.
Citicoline (cytidine-5'-diphosphocholine) is an essential precursor in the synthesis of phosphatidylcholine, a component of cell membranes.
- Trial name
- NCT04009980
- Testing
- OMK2 group
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Type 2 Diabetes
Effect of EPA-DHA Supplement, Life Style Modification Standard Treatment on Clinical Outcome Lipid Membrane Composition in Type 2 Diabetes
The aim of the present study is: to examine some of the mechanisms by which a change in life style alone or supplemented with a diet supplemented in n-3 PUFA, and associated with this computerized life style regulation reduces…
- Trial name
- NCT02705430
- Testing
- EPA and DHA capsules of 2 g/day, Stress management phone application (Eco Fusion Mentally), life style program using a mobile phone (Eco Mentally and NewMe)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus, Type 1
Evaluation of a Booster Administration of GAD-alum (Diamyd®) in Individuals With Type 1 Diabetes
The objective of the study is to evaluate the feasibility and safety of administering a 4th or 5th intralymphatic booster dose of GAD-alum (Diamyd®) to T1D patients carrying HLA DR3-DQ2, who have earlier been treated with three…
- Trial name
- NCT05351879
- Testing
- GAD-alum (Diamyd) 40 μg/mL
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Linkoeping University
Type 2 Diabetes
The Application of Extremely Low Level Magnetic Fields as Adjunctive Treatment for Type II Diabetes
The purpose of this study is to see if using a device called the Resonator, that puts out very low level electromagnetic fields, effects blood glucose and A1c levels in people with Type 2 Diabetes.
- Trial name
- NCT00982293
- Testing
- Resonator device
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Gestational Diabetes
Online Self-learning for Women With Gestational Diabetes Mellitus
This study aims to determine the feasibility and acceptability of using telehealth in the care of women with Gestational Diabetes Mellitus (GDM) by providing a self-learning alternative via an online portal compared to a…
- Trial name
- iSelf-Learn (NCT05188625)
- Testing
- Telesupport - Telehealth
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Childhood Cancer Survivors Treated With Abdominal Radiation
Assessing Insulin Sensitivity and Diabetes Risk in Childhood Cancer Survivors Treated With Abdominal Irradiation
The purpose of this study is to better understand the risk factors and causes of diabetes in people who received radiation to the abdomen as children.
- Trial name
- NCT02248779
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Type 2 Diabetes Mellitus, Hypoglycemia
Effects of a Health Intervention on Hypoglycemic Coping : a Pilot Study
From August 2023 to January 2024, 100 patients with type 2 diabetes who met the inclusion and exclusion criteria were selected from the endocrinology department of The purpose of this study was to construct a hypoglycemia coping…
- Conditions
- Type 2 Diabetes Mellitus, Hypoglycemia, Health Education
- Trial name
- NCT06384118
- Testing
- Impact of an IMB theory-based health education intervention on hypoglycemic coping in patients with type 2 diabetes: a pilot study
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yating Liu
Type 2 Diabetes
Pilot Study Assessing Insulin Pump Therapy in Type 2 Diabetes
16-week, open-label, multi-center pilot study. Insulin pump naïve subjects with type 2 diabetes who are not achieving glycemic targets (screening A1C ≥ 7.0%) on an established regimen of either: 1) ≥ 2 OAs (Cohort A), 2) basal…
- Trial name
- NCT00922649
- Testing
- Insulin Pump therapy
- Where
- 6 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Animas Corporation
Diabetes Mellitus, Type 2, Heart Failure, Congestive
Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study
To conduct a pilot study to evaluate the feasibility of a large randomized controlled trial (RCT) of metformin in patients with heart failure and type 2 diabetes and to generate initial morbidity and mortality estimates in this…
- Trial name
- NCT00325910
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Biliary Tract Neoplasms, Liver Cancer
A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)
BACKGROUND: Various tumor ablative procedures and techniques have been shown to result in immunogenic cell death and induction of a peripheral immune response.
- Conditions
- Biliary Tract Neoplasms, Liver Cancer, Hepatocellular Carcinoma, Cholangiocarcinoma
- Trial name
- NCT02821754
- Testing
- Durvalumab, Tremelimumab, Trans-arterial Catheter Chemoembolization (TACE)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus, Type 2
Insulin Glargine in Type 2 Diabetes Mellitus
Primary objective: To evaluate in explorative manner the fasting blood glucose (FBG) coefficient of variability (CV)calculated on SMBG values (SMBG : Self-Monitoring of Blood Glucose).
- Trial name
- NCT00272077
- Testing
- Insuline glargine
- Sponsor
- Sanofi
Type 1 Diabetes
Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Type 1 Diabetes Mellitus
OPERA Study is a randomized, open-label, prospective, pilot, and a monocentric clinical trial involving outpatients within Abu Dhabi Stem Cells Center (ADSCC) with a confirmed diagnosis of type 1 diabetes mellitus (T1DM).
- Trial name
- OPERA (NCT05413005)
- Testing
- ECP regular-intensity arm, ECP accelerated-intensity arm, T1DM standard of care
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Abu Dhabi Stem Cells Center
Syndrome
Leptin to Treat Severe Insulin Resistance - Pilot Study
This pilot study will evaluate the safety and effectiveness of leptin therapy in two children with severe insulin resistance syndrome.
- Trial name
- NCT00027456
- Testing
- Leptin A-100
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-healing Wounds
Effect of Natrox Oxygen Wound Therapy on Non-healing Wounds and Implication of Remote Monitoring and Telehealth for Management in the Home.
Single center pilot study examining the effect of Natrox topical oxygen therapy on chronic wounds along with the introduction of remote monitoring and telehealth for home care management.
- Trial name
- NCT04746573
- Testing
- Natrox Topical Oxygen Therapy
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Inotec AMD Limited
Diabetes Mellitus Type 2
Evaluation of Lixisenatide Efficacy in Diabetes Mellitus Type 2 With Failure of Other GLP-1 Analog
The study aims to examine the effectiveness of the short acting GLP-1 analog, Lixisenatide to achieve glycemic control in type 2 diabetes patients, in patients with failure of long acting GLP-1 analog.
- Trial name
- NCT02767596
- Testing
- Lixisenatide, Basal insulins
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Laniado Hospital
Cystic Fibrosis, Diabetes Related Cystic Fibrosis
Metabolic Efficiency of Combined Pancreatic Islet and Lung Transplant for the Treatment of End-Stage Cystic Fibrosis
Patients with end-stage cystic fibrosis (CF) and severe CF-related diabetes (CFRD) may benefit from combined lung-pancreatic islet transplantation.
- Conditions
- Cystic Fibrosis, Diabetes Related Cystic Fibrosis, Insulin-dependent Diabetes
- Trial name
- PIM (NCT01548729)
- Testing
- Combined pancreatic islet and lung transplantation
- Where
- 28 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Kidney Transplant Recipients
The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients
The study aims to determine the short-term efficacy, mechanisms and safety of 12 weeks of dapagliflozin and semaglutide combination therapy in 20 KTR, with and without T2D.
- Trial name
- HALLMARK (NCT05938712)
- Testing
- Dapagliflozin 10 MG, Semaglutide, 1.0 mg/mL
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto