Clinical trials: Diabetes Treatment (Pilot Study)
Foot Ulcer, Diabetic
Pilot Study of the Safety and Clinical Efficacy of Topical Dermacyn™ Wound Care to Treat Mild Diabetic Foot Infections
To compare the rates of clinical success of Topical Dermacyn™ vs. Oral Levofloxacin vs. Combined therapy, in subjects with mild diabetic foot infections in non-ischemic ulcers.
- Trial name
- NCT00516958
- Testing
- Topical Dermacyn, Topical Dermacyn and Levofloxacin, Topical Saline and Levofloxacin
- Where
- 16 sites in United States
- Volunteers
- 65 people
- Sponsor
- Oculus Innovative Sciences, Inc.
Type 2 Diabetes
Treatment Burden Screening Questionnaire Pilot Study
The main objective of this study is to develop and evaluate a clinic-based pilot intervention to optimize patient-centered diabetes care for low income patients at risk for low quality diabetes care and poor outcomes.
- Trial name
- TBQ (NCT05870202)
- Testing
- screening tool
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Minnesota
Type2 Diabetes, Heart Failure
Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)
It is a mechanistic proof-of-concept study to demonstrate how SGLT-2 inhibitors (Canagliflozin) may have a beneficial role on cardiac energetic efficiency.
- Trial name
- Canacardia (NCT03298009)
- Testing
- Canagliflozin 100mg, PET imaging
- Sponsor
- Université de Sherbrooke
Hypotension
Study of Dopamine Versus Vasopressin for Treatment of Low Blood Pressure in Low Birth Weight Infants
Low blood pressure or hypotension is a very important problem that is often seen in premature babies, especially those with low birth weight.
- Trial name
- NCT01318278
- Testing
- Dopamine, Arginine Vasopressin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Baylor College of Medicine
Type 1 Diabetes
Validation of a Biomathematical Model to Help Identify the Parameters of Flexible Insulin Therapy
Type 1 diabetes is an autoimmune disease that requires daily treatment with insulin. The use of subcutaneous pumps for continuous insulin delivery has been an important advance for diabetic patients.
- Trial name
- ModIF (NCT04572009)
- Testing
- Bio-mathematical model, Without bio-mathematical model
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Nantes University Hospital
Diabetic Neuropathies
Effect of Spinal Cord Stimulation in Painful Diabetic Polyneuropathy
Rationale: Diabetic neuropathy is one of the most common complications of Diabetes Mellitis (DM). Pain is a common symptom of diabetic neuropathy, affecting 11-34% of patients suffering form DM.
- Trial name
- SCS (NCT00802022)
- Testing
- spinal cord stimulation
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center
Gestational Diabetes Mellitus in Pregnancy
Carbohydrates Distribution in Pregnancy Study
Hypothesis: Patients with Gestational Diabetes Mellitus (GDM) have a high risk to develop complications during pregnancy, puerperium and in the newborn.
- Trial name
- CHiPS (NCT03378908)
- Testing
- Intervention Treatment
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Germans Trias i Pujol Hospital
Foot Ulcer, Diabetes Mellitus
Efficacy Of CACIPLIQ20 On Diabetic Ulcers In Patients Wearing An Nonremovable, Windowed, Fiberglass Cast Boot
CACIPLIQ20 is a nanopolymer engineered to mimic glycosaminoglycans such as heparan sulfates. Glycosaminoglycans are implied 1) in the stabilization of the micro-environment of cells, known as extracellular matrix, by binding to…
- Conditions
- Foot Ulcer, Diabetes Mellitus, Diabetic Neuropathy
- Trial name
- DIAPLIQ (NCT01474473)
- Testing
- CACIPLIQ20 and Nonremovable, Windowed, Fiberglass Cast Boot
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement
IDDM
A Pilot Study of Continuous Subcutaneous Pramlintide Infusion Therapy in Patients With Type 1 Diabetes
This research project will investigate the effects of pramlintide (Symlin) given by continuous subcutaneous (under the skin) infusion throughout the day and night, along with meal doses similar to those injected during…
- Trial name
- NCT00502138
- Testing
- Continuous Pramlintide infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University Diabetes & Endocrine Consultants
Peripheral Neuropathy, Diabetes Mellitus
Oral Thiamine for the Treatment of Painful Diabetic Peripheral Neuropathy
This study will examine the effect of oral thiamine (Vitamin B1) supplementation on pain in patients with diabetic peripheral neuropathy.
- Conditions
- Peripheral Neuropathy, Diabetes Mellitus, Diabetes Complications
- Trial name
- NCT00279266
- Testing
- Thiamine
- Where
- United States
- Sponsor
- Loma Linda University
Type 1 Diabetes Mellitus
Pramlintide and Fiasp Closed-Loop With a Simple Meal Announcement
The aim of this pilot study is to generate preliminary data of (i) Fiasp-plus-Pramlintide closed-loop system with a simple meal announcement, compared to (ii) Fiasp-alone closed-loop system with full carbohydrate counting, in…
- Trial name
- NCT03993366
- Testing
- Fiasp+Pramlintide Closed-Loop System, Fiasp Closed-Loop System
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University
Diabetes
StartRIGHT: A Pilot Research Study About Diabetes Diagnosis & Treatment
This study aims to achieve more accurate early classification of diabetes and identification of which patients will rapidly require insulin treatment.
- Trial name
- StartRIGHT (NCT02287506)
- Testing
- Optimised Diagnostic Strategy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Diabetic Foot Ulcer, Diabetic Foot Ulcer Neuropathic
Diabetic Foot Ulcer Research Study
The goal of this clinical trial is to compare safety and performance of the study device to the current typical NHS standards of care device.
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot Ulcer Neuropathic, Diabetic Foot Ulcer Ischemic
- Trial name
- NCT05762432
- Testing
- Wound Dressing, NHS Standard Dressing
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Community Pharmacology Services Ltd
Type 2 Diabetes, End Stage Renal Disease
Using Sitagliptin as a Treatment to Prevent New Onset Diabetes After Kidney Transplantation
This study is designed to see if the use of the drug Sitagliptin (used to reduce insulin resistance) will delay or prevent kidney transplant patients from getting diabetes.
- Trial name
- NCT00936663
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Nebraska
Prediabetic State, PreDiabetes
Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center
The purpose of the study is to assess the feasibility and acceptability of incorporating hands-on nutritional demonstrations to enhance the Diabetes Prevention Program (DPP) curriculum among patients who are at-risk for…
- Conditions
- Prediabetic State, PreDiabetes, Health Knowledge, Attitudes, Practice, Nutrition, Healthy
- Trial name
- NCT06897982
- Testing
- One-arm feasibility pilot of a nutrition intervention to recruit, engage, and retain DPP participants in the safety-net setting in Los Angeles
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Diabetes Mellitus, Type 1, Adrenal Insufficiency
Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal Failure
The purpose of this study is to measure how often low blood sugars occur in people who live with both adrenal insufficiency (AI) and diabetes and need to take insulin.
- Conditions
- Diabetes Mellitus, Type 1, Adrenal Insufficiency, Diabetes Mellitus Type 2 - Insulin-Treated
- Trial name
- HYPO-DIAD (NCT05806190)
- Testing
- Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Imperial College Healthcare NHS Trust
Diabetic Retinopathy, Retinal Neovascularisation
Ranibizumab in Diabetic Vitrectomy. A Prospective, Randomised Controlled Trial of Ranibizumab Pre-treatment in Diabetic Vitrectomy - a Pilot Study
This study will evaluate the effect of ranibizumab on patients undergoing vitrectomy surgery for the complications of diabetic retinopathy.
- Trial name
- RaDiVit (NCT01306981)
- Testing
- Ranibizumab, Saline
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Vascular Ulcer (Arterial or Venous Including Diabetic Ulcers Not Located on the Foot), Diabetic Foot Ulcer
A Pilot Study to Assess the Efficacy of NEOX® CORD 1K® in the Treatment of Complex Diabetic Wounds
Patients presenting to Johns Hopkins with a diabetic ulcer classified by the UT Grade 2 or 3 who meet all of the inclusion and none exclusion criteria and give their informed consent, will receive an application of NEOX CORD 1K…
- Conditions
- Vascular Ulcer (Arterial or Venous Including Diabetic Ulcers Not Located on the Foot), Diabetic Foot Ulcer, Diabetic Foot, Diabetic Foot Infection
- Trial name
- NCT03296436
- Testing
- NEOX® CORD 1K®
- Sponsor
- Johns Hopkins University
Type1 Diabetes Mellitus
Safety and Efficacy of BC LisPram
This pilot study is a 50-hour randomized, open-label, crossover study in an inpatient setting assessing the safety, pharmacodynamics, pharmacokinetics, and closed-loop efficacy of i) BC LisPram delivery and ii) rapid insulin…
- Trial name
- NCT04972175
- Testing
- 50-Hour Intervention - Rapid Insulin lispro, 50-Hour Intervention - BC LisPram
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Michael Tsoukas
Diabetic Foot
Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers
Summary of the problem: Diabetes has been described as the fastest growing health crisis of our time. It currently affects more than 4.5million people in the UK. The direct cost to the NHS is already over £1 billion per year.
- Trial name
- SOLEFUL1 (NCT05380544)
- Testing
- Extracorporeal Shockwave Therapy
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust